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           **Level**: advanced(%%)  **Type**: interactive tutorial | 
        
              
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           In this tutorial you will learn how to implement cell signalling function in the reaction-diffusion system by characterising your problems by the answers to three questions: (1) Where do the dynamics occur, (2) Who are the actors, and (3) How do they interact? | 
        
              
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          -=== [[Ball and Stick model part 3>>https://neuron.yale.edu/neuron/docs/ball-and-stick-model-part-3||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -=== [[Using the CellBuilder – Introduction>>https://neuron.yale.edu/neuron/static/docs/cbtut/main.html||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: interactive tutorial | 
        
              
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          -The following tutorials show how to use the CellBuilder, a powerful and convenient tool for constructing and managing models of individual neurons. It breaks the job of model specification into a sequence of tasks: | 
        
              
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          -1. Setting up model topology (branching pattern). | 
        
              
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          -2. Grouping sections with shared properties into subsets. | 
        
              
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          -3. Assigning geometric properties (length, diameter) to subsets or individual sections, and specifying a discretization strategy (i.e. how to set nseg). | 
        
              
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          -4. Assigning biophysical properties (Ra, cm, ion channels, buffers, pumps, etc.) to subsets or individual sections. | 
        
              
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          -=== [[Using Import3D – Exploring morphometric data and fixing problems>>https://neuron.yale.edu/neuron/docs/import3d/fix_problems||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -Import3D tool can be used to translate common varieties of cellular morphometric data into a CellBuilder that specifies the anatomical properties of a model neuron. This Tutorial will guide you through how to fix problems in your morphometric data. | 
        
              
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          -=== [[Randomness in NEURON models– The solution>>https://neuron.yale.edu/neuron/docs/solution||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -In this part of the tutorial we will show you how to give NetStim its own random number generator. | 
        
              
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          -=== [[Segmentation intro: Dealing with simulations that generate a lot of data>>https://neuron.yale.edu/neuron/docs/dealing-simulations-generate-lot-data||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -How to deal with simulations that generate a lot of data that must be saved? We will showcase different approaches. | 
        
              
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          -=== [[Using the Channel Builder – Creating a channel from an HH-style specification>>https://neuron.yale.edu/neuron/static/docs/chanlbild/hhstyle/outline.html||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: interactive tutorial | 
        
              
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          -Our goal is to implement a new voltage-gated macroscopic current whose properties are described by HH-style equations. | 
        
              
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          -=== [[Using the Channel Builder – Creating a channel from a kinetic scheme specification>>https://neuron.yale.edu/neuron/static/docs/chanlbild/kinetic/outline.html||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: interactive tutorial | 
        
              
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          -Here we will implement a new voltage-gated macroscopic current whose properties are described by a family of chemical reactions. | 
        
              
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          -=== [[Randomness in NEURON models– Source code that demonstrates the solution>>https://neuron.yale.edu/neuron/docs/source-code-demonstrates-solution||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -=== [[Using the Network Builder – Introduction to Network Construction>>https://neuron.yale.edu/neuron/static/docs/netbuild/intro.html||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -=== [[Python introduction>>https://neuron.yale.edu/neuron/docs/python-introduction||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -This page provides a brief introduction to Python syntax, Variables, Lists and Dicts, For loops and iterators, Functions, Classes, Importing modules, Writing and reading files with Pickling. | 
        
              
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          -=== [[Reaction-Diffusion Example – RxD with MOD files>>https://neuron.yale.edu/neuron/docs/rxd-mod-files||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -NEURON's reaction-diffusion infrastructure can be used to readily allow intracellular concentrations to respond to currents generated in MOD files. This example shows you a simple model with just a single point soma, of length and diameter 10 microns, with Hodgkin-Huxley kinetics, and dynamic sodium (declared using rxd but without any additional kinetics). | 
        
              
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          -=== [[Segmenting a simulation of a model network - Introduction>>https://neuron.yale.edu/neuron/docs/segmenting-simulation-model-network||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -=== [[Using the Network Builder – Tutorial 1: Making Networks of Artificial Neurons>>https://neuron.yale.edu/neuron/static/docs/netbuild/artnet/outline.html||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: interactive tutorial | 
        
              
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          -Learn how to Artificial Integrate and Fire cell with a synapse that is driven by an afferent burst of spikes. | 
        
              
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          -=== [[Reaction-Diffusion Example – Restricting a reaction to part of a region>>https://neuron.yale.edu/neuron/docs/example-restricting-reaction-part-region||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -Implementation example for the restriction of the reaction to part of a region. | 
        
              
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          -=== [[Segmenting a simulation of a model cell - Introduction>>https://neuron.yale.edu/neuron/docs/segmenting-simulation-model-cell||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -=== [[Scripting NEURON basics>>https://neuron.yale.edu/neuron/docs/scripting-neuron-basics||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -The objectives of this part of the tutorial are to get familiar with basic operations of NEURON using Python. In this worksheet we will: Create a passive cell membrane in NEURON. Create a synaptic stimulus onto the neuron. Modify parameters of the membrane and stimulus. Visualize results with bokeh. | 
        
              
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          -=== [[Reaction-Diffusion – Thresholds>>https://neuron.yale.edu/neuron/docs/reaction-diffusion-thresholds||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: interactive tutorial | 
        
              
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          -Learn how to scale reaction rates by a function of the form f(x) for suitably chosen a and m to approximately threshold them by a concentration. | 
        
              
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          -=== [[Randomness in NEURON models>>https://neuron.yale.edu/neuron/docs/randomness-neuron-models||rel=" noopener noreferrer" target="_blank"]] === | 
        
              
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          -**Level**: advanced(%%)  **Type**: user documentation | 
        
              
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          -We will touch upon the following subjects in this tutorial:  | 
        
              
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          -How to create model specification code that employs randomization to avoid undesired correlations between parameters, and to produce a model cell or network that has the same architecture and biophysical properties, and generates the same simulation results regardless of whether it is run on serial or parallel hardware. | 
        
              
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          -How to generate spike streams or other signals that fluctuate in ways that are statistically independent of each other. | 
        
              
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