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Title
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1 -Interactive Exploration of Brain States and Spatio-Temporal Activity Patterns in Data-Constrained Simulations
1 +Interactive Exploration of Brain States and Spatio Temporal Activity Patterns in Data-Constrained Simulations
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2 2  (((
3 3  (% class="container" %)
4 4  (((
5 -(% class="lead" id="HInteractiveExplorationofBrainStatesandSpatio-TemporalActivityPatternsinData-ConstrainedSimulations" %)
6 -Explore brain states and spatio-temporal cortical activity patterns on your own
5 += My Collab's Extended Title =
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7 +My collab's subtitle
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8 8  )))
9 9  
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12 12  (% class="col-xs-12 col-sm-8" %)
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14 -(% class="lead" id="HOpentheLablinkonthelefttolaunchtheinteractivesimulation" %)
15 -Open the Lab link on the left to launch the interactive simulation
15 += What can I find here? =
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17 -How the same network can generate different brain states with their specific propagation patterns and rhythms?
17 +* Notice how the table of contents on the right
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19 -In this Jupyter Lab the user can interactively change the neuromodulated fatigue parameters and observe in real-time the emergence of different categories of slow- wave wave-propagation patterns and the transition to an asynchronous regime on a columnar mean-field model equipped with lateral connections inferred from experimentally acquired cortical activity.
21 += Who has access? =
20 20  
21 -The model displays the dorsal view of a mouse cortical hemisphere sampled by pixels of 100-micron size over a 25 mm2 field of view.
22 -
23 -The connectivity of the model was inferred from cortical activity acquired using GECI imaging technique. Even if the connectivity of the model was inferred from a single brain-state, the neuromodulated model supports the emergence of a rich dynamic repertoire of spatio-temporal propagation patterns, from those corresponding to deepests levels of anesthesia (spirals) to classical postero-anterior and rostro-caudal waves up to the transition to asynchronous activity, with the dissolution of the slow-wave features (1).
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25 -The experimental data set from which the model has been inferred has been provided by LENS and it is available in the EBRAINS KG (2)
26 -
27 -(1) Capone, C. et al. (2021) “Simulations Approaching Data: Cortical Slow Waves in Inferred Models of the Whole Hemisphere of Mouse” arXiv:2104.07445 [[https:~~/~~/arxiv.org/abs/2104.07445>>https://arxiv.org/abs/2104.07445]]
28 -
29 -(2) Resta, F., Allegra Mascaro, A. L., & Pavone, F. (2020). //Study of Slow Waves (SWs) propagation through wide-field calcium imaging of the right cortical hemisphere of GCaMP6f mice// [Data set]. EBRAINS. [[DOI: 10.25493/3E6Y-E8G>>url:https://doi.org/10.25493%2F3E6Y-E8G]]
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31 -= =
23 +Describe the audience of this collab.
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34 34  
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