Last modified by pierstanpaolucci on 2023/06/29 18:29
From version 46.1
edited by pierstanpaolucci
on 2022/03/25 09:55
Change comment: Update collab owner property to pierstanpaolucci
To version 47.1
edited by cristianocapone
on 2022/05/18 15:24
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16 16  (((
17 17  **How the same network can generate different brain states with their specific propagation patterns and rhythms?**
18 18  
19 -In this Jupyter Lab environment, the user can interactively change the neuromodulated fatigue parameters and observe in real-time the emergence of different categories of slow-wave wave-propagation patterns and the transition to an asynchronous regime on a columnar mean-field model equipped with lateral connections inferred from experimentally acquired cortical activity.
19 +In this Jupyter Lab environment, the user can interactively change the neuromodulation and adaptation parameters and observe in real-time the emergence of different categories of slow-wave wave-propagation patterns (spontaneous and evoked) and the transition to an asynchronous regime on a columnar mean-field model equipped with lateral connections inferred from experimentally acquired cortical activity.
20 20  
21 21  [[image:snap_1.png||height="364" width="658"]]
22 22  
23 +**Stimulus OFF**
23 23  
24 24  [[image:snap_2.png||height="237" width="606"]]
25 25  
27 +**Stimulus ON**
26 26  
29 +[[image:snap_2.png||height="237" width="606"]]
30 +
31 +**Acknowledgment**
32 +
27 27  The model displays the dorsal view of a mouse cortical hemisphere sampled by pixels of 100-micron size over a 25 mm2 field of view.
28 28  
29 29  The connectivity of the model was inferred from cortical activity acquired using GECI imaging technique. Even if the connectivity of the model was inferred from a single brain-state, the neuromodulated model supports the emergence of a rich dynamic repertoire of spatio-temporal propagation patterns, from those corresponding to deepests levels of anesthesia (spirals) to classical postero-anterior and rostro-caudal waves up to the transition to asynchronous activity, with the dissolution of the slow-wave features (1).