Last modified by pierstanpaolucci on 2023/06/29 18:29
From version 6.1
edited by cristianocapone
on 2021/09/21 12:38
Change comment: There is no comment for this version
To version 9.2
edited by pierstanpaolucci
on 2021/09/21 15:37
Change comment: There is no comment for this version

Summary

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Title
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1 -Interactive Exploration of Brain States and Spatio Temporal Activity Patterns in Data-Constrained Simulations
1 +Interactive Exploration of Brain States and Spatio-Temporal Activity Patterns in Data-Constrained Simulations
Author
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1 -XWiki.cristianocapone
1 +XWiki.pierstanpaolucci
Content
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14 14  (((
15 15  (% class="col-xs-12 col-sm-8" %)
16 16  (((
17 -= What can I find here? =
17 += Open the Lab link on the left to launch the interactive simulation =
18 18  
19 -* Notice how the table of contents on the right
20 -* is automatically updated
21 -* to hold this page's headers
19 +How the same network can generate different brain states with their specific propagation patterns and rhythms?
22 22  
23 -= Who has access? =
21 +In this Jupyter Lab the user can interactively change the neuromodulated fatigue parameters and observe in real-time the emergence of different categories of slow- wave wave-propagation patterns and the transition to an asynchronous regime on a columnar mean-field model equipped with lateral connections inferred from experimentally acquired cortical activity.
24 24  
25 -Describe the audience of this collab.
23 +The model displays the dorsal view of a mouse cortical hemisphere sampled by pixels of 100-micron size over a 25 mm2 field of view.
24 +
25 +The connectivity of the model was inferred from cortical activity acquired using GECI imaging technique. Even if the connectivity of the model was inferred from a single brain-state, the neuromodulated model supports the emergence of a rich dynamic repertoire of spatio-temporal propagation patterns, from those corresponding to deepests levels of anesthesia (spirals) to classical postero-anterior and rostro-caudal waves up to the transition to asynchronous activity, with the dissolution of the slow-wave features (1).
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27 +The experimental data set from which the model has been inferred has been provided by LENS and it is available in the EBRAINS KG(2)
28 +
29 +(1) Capone, C. et al. (2021) “Simulations Approaching Data: Cortical Slow Waves in Inferred Models of the Whole Hemisphere of Mouse” arXiv:2104.07445 https:~/~/arxiv.org/abs/2104.07445
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31 += =
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