Last modified by pierstanpaolucci on 2023/06/29 18:29
From version 8.1
edited by pierstanpaolucci
on 2021/09/21 15:29
Change comment: There is no comment for this version
To version 23.1
edited by cristianocapone
on 2021/09/23 13:36
Change comment: There is no comment for this version

Summary

Details

Page properties
Author
... ... @@ -1,1 +1,1 @@
1 -XWiki.pierstanpaolucci
1 +XWiki.cristianocapone
Content
... ... @@ -2,11 +2,8 @@
2 2  (((
3 3  (% class="container" %)
4 4  (((
5 -= Interactive Exploration of Brain States and Spatio-Temporal Activity Patterns in Data-Constrained Simulations =
6 -
7 -= =
8 -
9 -Explore brain states and spatio-temporal cortical activity patterns on your own
5 +(% class="lead" id="HInteractiveExplorationofBrainStatesandSpatio-TemporalActivityPatternsinData-ConstrainedSimulations" %)
6 +Open the Lab link on the left to explore brain states and spatio-temporal cortical activity patterns on your own
10 10  )))
11 11  )))
12 12  
... ... @@ -14,13 +14,34 @@
14 14  (((
15 15  (% class="col-xs-12 col-sm-8" %)
16 16  (((
17 -(% class="wikigeneratedid" %)
18 -= Open the Lab to launch the interactive simulation =
14 +**How the same network can generate different brain states with their specific propagation patterns and rhythms?**
19 19  
20 -= =
21 -)))
16 +In this Jupyter Lab environment, the user can interactively change the neuromodulated fatigue parameters and observe in real-time the emergence of different categories of slow- wave wave-propagation patterns and the transition to an asynchronous regime on a columnar mean-field model equipped with lateral connections inferred from experimentally acquired cortical activity.
22 22  
18 +[[image:example1.png]]
23 23  
20 +[[image:example2.png]]
21 +
22 +The model displays the dorsal view of a mouse cortical hemisphere sampled by pixels of 100-micron size over a 25 mm2 field of view.
23 +
24 +The connectivity of the model was inferred from cortical activity acquired using GECI imaging technique. Even if the connectivity of the model was inferred from a single brain-state, the neuromodulated model supports the emergence of a rich dynamic repertoire of spatio-temporal propagation patterns, from those corresponding to deepests levels of anesthesia (spirals) to classical postero-anterior and rostro-caudal waves up to the transition to asynchronous activity, with the dissolution of the slow-wave features (1).
25 +
26 +The experimental data set from which the model has been inferred has been provided by LENS and it is available in the EBRAINS KG (2).
27 +
28 +The predecessor of this model can be found at (3).
29 +
30 +The latest version of the code presented in the drive of this collab can be found at (4).
31 +
32 +(1) Capone, C. et al. (2021) “Simulations Approaching Data: Cortical Slow Waves in Inferred Models of the Whole Hemisphere of Mouse” arXiv:2104.07445 [[https:~~/~~/arxiv.org/abs/2104.07445>>https://arxiv.org/abs/2104.07445]]
33 +
34 +(2) Resta, F., Allegra Mascaro, A. L., & Pavone, F. (2020). //Study of Slow Waves (SWs) propagation through wide-field calcium imaging of the right cortical hemisphere of GCaMP6f mice// [Data set]. EBRAINS. [[DOI: 10.25493/3E6Y-E8G>>url:https://doi.org/10.25493%2F3E6Y-E8G]]
35 +
36 +(3) Mean Field Simulation of whole mouse hemisphere with parameters inferred from optical recordings [[https:~~/~~/search.kg.ebrains.eu/instances/e572362f-9461-4f9d-81e2-b69cd44185f4>>https://search.kg.ebrains.eu/instances/e572362f-9461-4f9d-81e2-b69cd44185f4]]
37 +
38 +(% class="wikigeneratedid" id="H" %)
39 +(4) [[https:~~/~~/github.com/APE-group/InteractiveExplorationBrainStates>>https://github.com/APE-group/InteractiveExplorationBrainStates]]
40 +)))
41 +
24 24  (% class="col-xs-12 col-sm-4" %)
25 25  (((
26 26  {{box title="**Contents**"}}
... ... @@ -27,6 +27,9 @@
27 27  {{toc/}}
28 28  {{/box}}
29 29  
48 +
49 +
50 +
30 30  
31 31  )))
32 32  )))
example1.png
Author
... ... @@ -1,0 +1,1 @@
1 +XWiki.cristianocapone
Size
... ... @@ -1,0 +1,1 @@
1 +802.5 KB
Content
example2.png
Author
... ... @@ -1,0 +1,1 @@
1 +XWiki.cristianocapone
Size
... ... @@ -1,0 +1,1 @@
1 +389.2 KB
Content
XWiki.XWikiRights[3]
Allow/Deny
... ... @@ -1,0 +1,1 @@
1 +Allow
Levels
... ... @@ -1,0 +1,1 @@
1 +view
Users
... ... @@ -1,0 +1,1 @@
1 +XWiki.XWikiGuest