Version 15.1 by pierstanpaolucci on 2021/09/22 10:42
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6 (% style="background-color:#ffffff; color:#f39c12" %)Explore brain states and spatio-temporal cortical activity patterns on your own
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15 Open the Lab link on the left to launch the interactive simulation
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17 How the same network can generate different brain states with their specific propagation patterns and rhythms?
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19 In this Jupyter Lab the user can interactively change the neuromodulated fatigue parameters and observe in real-time the emergence of different categories of slow- wave wave-propagation patterns and the transition to an asynchronous regime on a columnar mean-field model equipped with lateral connections inferred from experimentally acquired cortical activity.
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21 The model displays the dorsal view of a mouse cortical hemisphere sampled by pixels of 100-micron size over a 25 mm2 field of view.
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23 The connectivity of the model was inferred from cortical activity acquired using GECI imaging technique. Even if the connectivity of the model was inferred from a single brain-state, the neuromodulated model supports the emergence of a rich dynamic repertoire of spatio-temporal propagation patterns, from those corresponding to deepests levels of anesthesia (spirals) to classical postero-anterior and rostro-caudal waves up to the transition to asynchronous activity, with the dissolution of the slow-wave features (1).
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25 The experimental data set from which the model has been inferred has been provided by LENS and it is available in the EBRAINS KG (2)
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27 The predecessor of this model can be found at (3)
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29 (1) Capone, C. et al. (2021) “Simulations Approaching Data: Cortical Slow Waves in Inferred Models of the Whole Hemisphere of Mouse” arXiv:2104.07445 [[https:~~/~~/arxiv.org/abs/2104.07445>>https://arxiv.org/abs/2104.07445]]
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31 (2) Resta, F., Allegra Mascaro, A. L., & Pavone, F. (2020). //Study of Slow Waves (SWs) propagation through wide-field calcium imaging of the right cortical hemisphere of GCaMP6f mice// [Data set]. EBRAINS. [[DOI: 10.25493/3E6Y-E8G>>url:https://doi.org/10.25493%2F3E6Y-E8G]]
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33 (3) Mean Field Simulation of whole mouse hemisphere with parameters inferred from optical recordings [[https:~~/~~/search.kg.ebrains.eu/instances/e572362f-9461-4f9d-81e2-b69cd44185f4>>https://search.kg.ebrains.eu/instances/e572362f-9461-4f9d-81e2-b69cd44185f4]]
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41 {{box title="**Contents**"}}
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