Live Figures of "State-dependent brain responsiveness, from local circuits to the whole brain"

A. Destexhe¹, J. Goldman¹, N. Tort-Colet¹, A. Roques¹, J. Fousek², S. Petkoski², V. Jirsa², O. David², M. Jedynak², C. Capone³, C. De Luca³, G. De Bonis³, P.S. Paolucci³, E. Mikulan⁴, A. Pigorini⁴, M. Massimini⁴, A. Galluzzi⁵, A. Pazienti⁵, M. Mattia⁵, A. Arena⁶, B.E. Juel⁶, E. Hagen⁶, J.F. Storm⁶, E. Montagni⁷, F. Resta⁷, F.S. Pavone⁷, A.L. Allegra Mascaro⁷, A. Dwarakanath⁸, T.I. Panagiotaropoulos⁸, J. Senk⁹, M. Diesmann⁹, A. Camassa¹⁰, L. Dalla Porta¹⁰, A. Manasanch¹⁰, M.V. Sanchez-Vives^{10, 11}

1. Paris-Saclay University, Institute of Neuroscience (NeuroPSI), CNRS, Saclay, France.
2. Aix-Marseille University, Marseille, France
3. INFN, Rome, Italy
4. UMIL, Milan, Italy
5. ISS, Rome, Italy
6. UiO, Oslo, Norway
7. LENS, Florence, Italy
8. CEA, NeuroSpin, France
9. FZJ, Julich, Germany
10. IDIBAPS, Barcelona, Spain
11. ICREA, Barcelona, Spain

Abstract

The objective of this paper is to review physiological and computational aspects of the responsiveness of the cerebral cortex to stimulation, and how responsiveness depends on the state of the system. This correspondence between brain state and brain responsiveness (state-dependent responses) is outlined at different scales from cellular and circuit level, to the mesoscale and the macroscale level. At each scale, we review how quantitative methods can be used to characterize network states based on brain responses, such as the Perturbational Complexity Index (PCI). This description will compare data and models, systematically and at multiple scales, with a focus on the mechanisms that explain how brain responses depend on brain states. 

The Live Figures

The review "State-dependent brain responsiveness, from local circuits to the whole brain" is accompanied by data and figures that readers can interact with for increased understanding of the core concepts described in the text. These Live Figures are hosted here, on EBRAINS, and this page is the common entry point to find them. 

Link to the notebooks to execute the Live Figures:

The notebooks are hosted in the Drive of this Collab. 

The following links will open an EBRAINS Jupyter Lab instance. To execute them, you need an EBRAINS account. 

Questions or issues can be directed to Alain Destexhe (alain.destexhe@cnrs.fr), Mavi Sanchez-Vives (msanche3@recerca.clinic.cat) or Arnau Manasanch (manasanch@recerca.clinic.cat)