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Last modified by glennvdlande on 2023/10/10 10:52
From version 15.1
edited by glennvdlande
on 2023/10/10 10:52
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edited by arnaumanasanch
on 2023/09/25 19:53
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Summary

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1 -XWiki.glennvdlande
1 +XWiki.arnaumanasanch
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2 2  (((
3 3  (% class="container" %)
4 4  (((
5 -= **Live Figures** of "**Brain state identification and neuromodulation to promote recovery of consciousness**" =
5 += **Live Figures** of "Identification and neuromodulation of brain states to promote recovery of consciousness" =
6 6  
7 7  (% class="wikigeneratedid" id="HGlennJ.M.vanderLande12C22CDianaCasas-Torremocha32CFranciscoClasca32CGustavoDeco42C52CPauGorostiza52C62C72COliviaGosseries12C22CStevenLaureys12C22C82C92CArnauManasanch102CJorgeF.MejEDas112CRajanikantPanda12C22CMariaV.SE1nchez-Vives52C102CBertrandThirion122CGorkaZamora-LF3pez42CJitkaAnnen12C2" %)
8 -Glenn J.M. van der Lande^^1,2^^, Arnau Manasanch^^3^^, Diana Casas-Torremocha^^3^^, Leonardo Dalla Porta^^3^^,^^ ^^Olivia Gosseries^^1,2^^, Naji Alnagger^^1,2^^, Alice Barra^^1,2^^, Jorge F. Mejías^^4^^, Rajanikant Panda^^1,2^^, Fabio Riefolo^^5,6,7^^, Aurore Thibaut^^1,2^^, Vincent Bonhomme^^8,9^^, Bertrand Thirion^^10^^, Francisco Clasca^^11^^, Pau Gorostiza^^5,6,12^^, Maria V. Sanchez-Vives^^3,12^^, Gustavo Deco^^12,13^^, Steven Laureys^^1,2,14,15^^, Gorka Zamora-López^^13^^, Jitka Annen^^1,2^^
8 +Glenn J.M. van der Lande ^^1,2^^, Diana Casas-Torremocha ^^3^^, Arnau Manasanch ^^3^^, Leonardo Dalla Porta ^^3^^, Olivia Gosseries ^^1,2^^, Naji Alnagger ^^1,2^^, Alice Barra ^^1,2^^, Jorge F. Mejías ^^4^^, Rajanikant Panda ^^1,2^^, Fabio Riefolo ^^5^^, Bertrand Thirion ^^6^^, Francisco Clasca ^^7^^, Pau Gorostiza ^^5,8,9^^, Maria V. Sanchez-Vives ^^3,10^^, Gustavo Deco ^^10,11^^, Steven Laureys ^^1,12,13,14^^, Gorka Zamora-López ^^11^^, Jitka Annen ^^1,2^^
9 9  
10 -{{{1GIGA-Consciousness, Coma Science Group, University of Liège, Liège, Belgium.
11 -2Centre du Cerveau2, University Hospital of Liège, Liège, Belgium.
12 -3Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain.
13 -4Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098XH Amsterdam, Netherlands.
14 -5Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology, Barcelona 08028, Spain.
15 -6Biomedical Research Networking Center in Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Madrid 28029, Spain.
16 -7Present address: Teamit Institute, Barcelona.
17 -8Department of Anesthesia and Intensive Care Medicine, Liege University Hospital, Liege, Belgium.
18 -9Anesthesia and Perioperative Neuroscience Laboratory, GIGA-Consciousness Thematic Unit, University of Liege, Liege, Belgium.
19 -10Inria, CEA, Université Paris-Saclay, Paris, France.
20 -11Department of Anatomy and Neuroscience, School of Medicine, Universidad Autónoma de Madrid, Madrid 28029, Spain.
21 -12Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
22 -13Computational Neuroscience Group, Center for Brain and Cognition, Universitat Pompeu Fabra, Barcelona, Spain.
23 -14Joint International Research Unit on Consciousness, CERVO Brain Research Centre, U Laval, Canada.
24 -15International Consciousness Science Institute, Hangzhou Normal University, Hangzhou, China.}}}
25 -)))
26 -)))
10 +(% class="small" %)^^1^^ GIGA-Consciousness, Coma Science Group, University of Liège, Liège, Belgium
27 27  
28 -== Abstract ==
12 +(% class="small" %)^^2^^ Centre du Cerveau2, University Hospital of Liège, Liège, Belgium.
29 29  
30 -Experimental and clinical studies of consciousness identify brain states (i.e., transient, relevant features of the brain associated with the state of consciousness) in a non-systematic manner and largely independent from the research into the induction of state changes. In this narrative review with a focus on patients with a disorder of consciousness (DoC), we synthesize advances on the identification of brain states associated with consciousness in animal models and physiological (sleep), pharmacological (anesthesia) and pathological (DoC) states of altered consciousness in human. We show that in reduced consciousness the frequencies in which the brain operates are slowed down and that the pattern of functional communication in the brain is sparser, less efficient, and less complex. The results also highlight damaged resting state networks, in particular the default mode network, decreased connectivity in long-range connections and in the thalamocortical loops. Next, we show that therapeutic approaches to treat DoC, through pharmacology (e.g., amantadine, zolpidem), and (non-)invasive brain stimulation (e.g., transcranial current stimulation, deep brain stimulation) have shown some effectiveness to promote consciousness recovery. It seems that these deteriorated features of conscious brain states may improve in response to these neuromodulation approaches, yet, targeting often remains non-specific and does not always lead to (behavioral) improvements. Furthermore, in silico model-based approaches allow the development of personalized assessment of the effect of treatment on brain-wide dynamics. Although still in infancy, the fields of brain state identification and neuromodulation of brain states in relation to consciousness are showing fascinating developments that, when united, might propel the development of new and better targeted techniques for DoC. For example, brain states could be identified in a predictive setting, and the theoretical and empirical testing (i.e., in animals, under anesthesia and patients with a DoC) of neuromodulation techniques to promote consciousness could be investigated. This review further helps to identify where challenges and opportunities lay for the maturation of brain state research in the context of states of consciousness. Finally, it aids in recognizing possibilities and obstacles for the clinical translation of these diagnostic techniques and neuromodulation treatment options across both the multi-modal and multi-species approaches outlined throughout the review.
14 +(% class="small" %)^^3^^ Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain
31 31  
32 -== The Full Paper ==
16 +(% class="small" %)^^4^^ Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098XH Amsterdam, Netherlands
33 33  
34 -This review is currently being submitted. A recent version of the manuscript can be found here: [[https:~~/~~/zenodo.org/record/8377867>>https://zenodo.org/record/8377867]].
18 +(% class="small" %)^^5^^ Biomedical Research Networking Center in Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Madrid 28029, Spain
35 35  
36 -== The Live Figures ==
20 +(% class="small" %)^^6^^ Inria, CEA, Université Paris-Saclay, Paris, France
37 37  
38 -The review "**Brain state identification and neuromodulation to promote recovery of consciousness"** is accompanied by data and figures that readers can interact with for increased understanding of the core concepts described in the text. These Live Figures are hosted here on EBRAINS, and this pages is the common entry point to find them.
22 +(% class="small" %)^^7^^ Department of Anatomy and Neuroscience, School of Medicine, Universidad Autónoma de Madrid, Madrid 28029, Spain
39 39  
24 +(% class="small" %)^^8^^ Institució Catalana de la Recerca i Estudis Avançats (ICREA), Barclona, Spain.
25 +
26 +(% class="small" %)^^9^^ Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology, Barcelona 08028, Spain
27 +
28 +(% class="small" %)^^10^^ Institució Catalana de la Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
29 +
30 +(% class="small" %)^^11^^ Computational Neuroscience Group, Center for Brain and Cognition, Universitat Pompeu Fabra, Barcelona, Spain.
31 +
32 +(% class="small" %)^^12^^ Centre du Cerveau2, University Hospital of Liège, Liège, Belgium
33 +
34 +(% class="small" %)^^13^^ Joint International Research Unit on Consciousness, CERVO Brain Research Centre, U Laval CANADA
35 +
36 +(% class="small" %)^^14^^ International Consciousness Science Institute, Hangzhou Normal University, Hangzhou, CHINA
37 +)))
38 +)))
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40 40  (% class="row" %)
41 41  (((
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43 43  (((
44 -==== Link to the notebooks to execute the Live Figures: ====
44 += Link to the notebooks to execute the Live Figures: =
45 45  
46 46  The notebooks are hosted in the [[Drive>>https://wiki.ebrains.eu/bin/edit/Collabs/live-paper-states-altered-consciousness/Drive]] of this Collab.
47 47  
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55 55  |(% style="width:677px" %)Control of brain state transitions with a photoswitchable muscarinic agonist|(% style="width:363px" %)[[https:~~/~~/t.ly/qSE8b>>url:https://t.ly/qSE8b]]
56 56  |(% style="width:677px" %)Changes in TMS-triggered slow wave activity in DoC after tDCS treatment|(% style="width:363px" %)[[https:~~/~~/t.ly/kqi9M>>url:https://t.ly/kqi9M]]
57 57  
58 -== Contact ==
59 -
60 -Questions or issues can be directed to Jitka Annen ([[jitka.annen@uliege.be>>mailto:jitka.annen@uliege.be]]), Arnau Manasanch ([[manasanch@recerca.clinic.cat>>mailto:manasanch@recerca.clinic.cat]]) or Glenn van der Lande ([[glenn.vanderlande@uliege.be>>mailto:glenn.vanderlande@uliege.be]]).
58 +
61 61  )))
62 62  
63 63  (% class="col-xs-12 col-sm-4" %)