Changes for page Neurodiagnoses
Last modified by manuelmenendez on 2025/03/03 22:46
From version 11.1
edited by manuelmenendez
on 2025/01/27 23:54
on 2025/01/27 23:54
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To version 4.5
edited by manuelmenendez
on 2025/01/27 23:00
on 2025/01/27 23:00
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... ... @@ -2,10 +2,9 @@ 2 2 ((( 3 3 (% class="container" %) 4 4 ((( 5 -= //A new tridimensionaldiagnostic framework for CNS conditions//=5 += Neurodiagnoses = 6 6 7 -This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies. 8 -We aim to create a structured, interpretable, and scalable diagnostic tool. 7 +This project is focused on developing a novel nosological and diagnostic framework for neurological diseases. Using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies, we aim to create a structured, interpretable, and scalable diagnostic tool. 9 9 ))) 10 10 ))) 11 11 ... ... @@ -13,68 +13,21 @@ 13 13 ((( 14 14 (% class="col-xs-12 col-sm-8" %) 15 15 ((( 16 -= What is this about and whatcan I find here? =15 += What can I find here? = 17 17 18 -== **Overview** == 17 +* `/docs`: Documentation and contribution guidelines. 18 +* `/code`: Machine learning pipelines and scripts. 19 +* `/data`: Sample datasets for testing. - `/outputs`: Generated models, visualizations, and reports. 19 19 20 - The//Tridimensional Diagnostic Framework// redefineshowneurodegenerative diseases(NDDs)areclassifiedby focusing on:21 += Who has access? = 21 21 22 -* **Axis 1**: Etiology (genetic/sporadic and environmental factors). 23 -* **Axis 2**: Molecular Markers (biomarkers and proteinopathies). 24 -* **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system). 25 - 26 -This methodology enables: 27 - 28 -* Greater precision in diagnosis. 29 -* Integration of incomplete datasets using AI-driven probabilistic modeling. 30 -* Stratification of patients for personalized treatment. 31 - 32 -== **Diagnostic Axes** == 33 - 34 -* ((( 35 -**Axis 1: Etiology** 36 - 37 -* //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers. 38 -* //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression. 39 -* //Tests//: Genetic testing, lifestyle and cardiovascular screening. 40 -))) 41 -* ((( 42 -**Axis 2: Molecular Markers** 43 - 44 -* //Description//: Analyzes primary (amyloid-beta, tau) and secondary biomarkers (NFL, GFAP) for tracking disease progression. 45 -* //Examples//: CSF amyloid-beta concentrations to confirm Alzheimer’s pathology. 46 -* //Tests//: Blood/CSF biomarkers, PET imaging (Tau-PET, Amyloid-PET). 47 -))) 48 -* ((( 49 -**Axis 3: Neuroanatomoclinical** 50 - 51 -* //Description//: Links clinical symptoms to neuroanatomical changes, such as atrophy or functional impairments. 52 -* //Examples//: Hippocampal atrophy correlating with memory deficits. 53 -* //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations. 54 -))) 55 - 56 -== **Applications** == 57 - 58 -This system enhances: 59 - 60 -* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials. 61 -* **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking. 62 - 63 -== Who has access? == 64 - 65 65 We welcome contributions from the global community. Let’s build the future of neurological diagnostics together! 66 66 67 -== How to Contribute == 25 +== How to Contribute: == 68 68 69 69 * Access the `/docs` folder for guidelines. 70 70 * Use `/code` for the latest AI pipelines. 71 71 * Share feedback and ideas in the wiki discussion pages. 72 - 73 -== Key Objectives == 74 - 75 -* Develop interpretable AI models for diagnosis and progression tracking. 76 -* Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources. 77 -* Foster collaboration among neuroscientists, AI researchers, and clinicians. 78 78 ))) 79 79 80 80 ... ... @@ -84,11 +84,11 @@ 84 84 {{toc/}} 85 85 {{/box}} 86 86 87 -== Maincontents ==39 +== Key Objectives: == 88 88 89 -* `/docs`:Documentation andcontributionguidelines.90 -* `/code`: Machinelearningpipelinesandscripts.91 -* `/data`: Sampledatasetsfortesting.92 - * `/outputs`: Generated models, visualizations, and reports.41 +* Develop interpretable AI models for diagnosis and progression tracking. 42 +* Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources. 43 +* Foster collaboration among neuroscientists, AI researchers, and clinicians. 44 + 93 93 ))) 94 94 )))
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