Changes for page Neurodiagnoses
Last modified by manuelmenendez on 2025/03/03 22:46
From version 13.1
edited by manuelmenendez
on 2025/01/27 23:54
on 2025/01/27 23:54
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To version 7.1
edited by manuelmenendez
on 2025/01/27 23:21
on 2025/01/27 23:21
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... ... @@ -15,7 +15,7 @@ 15 15 ((( 16 16 = What is this about and what can I find here? = 17 17 18 -== **Overview** == 18 +==== **Overview** ==== 19 19 20 20 The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on: 21 21 ... ... @@ -29,7 +29,7 @@ 29 29 * Integration of incomplete datasets using AI-driven probabilistic modeling. 30 30 * Stratification of patients for personalized treatment. 31 31 32 -== **Diagnostic Axes** == 32 +==== **Diagnostic Axes** ==== 33 33 34 34 * ((( 35 35 **Axis 1: Etiology** ... ... @@ -53,11 +53,28 @@ 53 53 * //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations. 54 54 ))) 55 55 56 -== ** Applications** ==56 +==== **Case Studies** ==== 57 57 58 +1. ((( 59 +**Sporadic Alzheimer’s Disease**: 60 + 61 +* Axis 1: Sporadic (ApoE4, poor sleep habits). 62 +* Axis 2: Amyloid-beta plaques, elevated NFL. 63 +* Axis 3: Right hippocampus atrophy (visual memory loss). 64 +))) 65 +1. ((( 66 +**Genetic Parkinson’s Disease**: 67 + 68 +* Axis 1: Genetic (LRRK2 mutation). 69 +* Axis 2: Alpha-synuclein aggregation. 70 +* Axis 3: Substantia nigra degeneration (motor dysfunction). 71 +))) 72 + 73 +==== **Applications** ==== 74 + 58 58 This system enhances: 59 59 60 -* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials. 77 +* **Research**: By stratifying patients, it reduces cohort heterogeneity in clinical trials. 61 61 * **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking. 62 62 63 63 == Who has access? == ... ... @@ -64,13 +64,13 @@ 64 64 65 65 We welcome contributions from the global community. Let’s build the future of neurological diagnostics together! 66 66 67 -== How to Contribute == 84 +== How to Contribute: == 68 68 69 69 * Access the `/docs` folder for guidelines. 70 70 * Use `/code` for the latest AI pipelines. 71 71 * Share feedback and ideas in the wiki discussion pages. 72 72 73 -== Key Objectives == 90 +== Key Objectives: == 74 74 75 75 * Develop interpretable AI models for diagnosis and progression tracking. 76 76 * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources. ... ... @@ -84,7 +84,7 @@ 84 84 {{toc/}} 85 85 {{/box}} 86 86 87 -== Main contents == 104 +== Main contents: == 88 88 89 89 * `/docs`: Documentation and contribution guidelines. 90 90 * `/code`: Machine learning pipelines and scripts.
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