Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
From version 13.1
edited by manuelmenendez
on 2025/01/27 23:54
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To version 7.1
edited by manuelmenendez
on 2025/01/27 23:21
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15 15  (((
16 16  = What is this about and what can I find here? =
17 17  
18 -== **Overview** ==
18 +==== **Overview** ====
19 19  
20 20  The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
21 21  
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29 29  * Integration of incomplete datasets using AI-driven probabilistic modeling.
30 30  * Stratification of patients for personalized treatment.
31 31  
32 -== **Diagnostic Axes** ==
32 +==== **Diagnostic Axes** ====
33 33  
34 34  * (((
35 35  **Axis 1: Etiology**
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53 53  * //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
54 54  )))
55 55  
56 -== **Applications** ==
56 +==== **Case Studies** ====
57 57  
58 +1. (((
59 +**Sporadic Alzheimer’s Disease**:
60 +
61 +* Axis 1: Sporadic (ApoE4, poor sleep habits).
62 +* Axis 2: Amyloid-beta plaques, elevated NFL.
63 +* Axis 3: Right hippocampus atrophy (visual memory loss).
64 +)))
65 +1. (((
66 +**Genetic Parkinson’s Disease**:
67 +
68 +* Axis 1: Genetic (LRRK2 mutation).
69 +* Axis 2: Alpha-synuclein aggregation.
70 +* Axis 3: Substantia nigra degeneration (motor dysfunction).
71 +)))
72 +
73 +==== **Applications** ====
74 +
58 58  This system enhances:
59 59  
60 -* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
77 +* **Research**: By stratifying patients, it reduces cohort heterogeneity in clinical trials.
61 61  * **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
62 62  
63 63  == Who has access? ==
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64 64  
65 65  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
66 66  
67 -== How to Contribute ==
84 +== How to Contribute: ==
68 68  
69 69  * Access the `/docs` folder for guidelines.
70 70  * Use `/code` for the latest AI pipelines.
71 71  * Share feedback and ideas in the wiki discussion pages.
72 72  
73 -== Key Objectives ==
90 +== Key Objectives: ==
74 74  
75 75  * Develop interpretable AI models for diagnosis and progression tracking.
76 76  * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
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84 84  {{toc/}}
85 85  {{/box}}
86 86  
87 -== Main contents ==
104 +== Main contents: ==
88 88  
89 89  * `/docs`: Documentation and contribution guidelines.
90 90  * `/code`: Machine learning pipelines and scripts.
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