Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
From version 14.1
edited by manuelmenendez
on 2025/01/27 23:58
Change comment: There is no comment for this version
To version 6.1
edited by manuelmenendez
on 2025/01/27 23:21
Change comment: There is no comment for this version

Summary

Details

Page properties
Content
... ... @@ -2,7 +2,8 @@
2 2  (((
3 3  (% class="container" %)
4 4  (((
5 -= //A new tridimensional diagnostic framework for CNS conditions// =
5 += **Neurodiagnoses**
6 +//A new tridimensional diagnostic framework for CNS conditions// =
6 6  
7 7  This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 8  We aim to create a structured, interpretable, and scalable diagnostic tool.
... ... @@ -15,7 +15,7 @@
15 15  (((
16 16  = What is this about and what can I find here? =
17 17  
18 -== **Overview** ==
19 +==== **Overview** ====
19 19  
20 20  The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
21 21  
... ... @@ -23,8 +23,6 @@
23 23  * **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
24 24  * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 25  
26 -[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
27 -
28 28  This methodology enables:
29 29  
30 30  * Greater precision in diagnosis.
... ... @@ -31,7 +31,7 @@
31 31  * Integration of incomplete datasets using AI-driven probabilistic modeling.
32 32  * Stratification of patients for personalized treatment.
33 33  
34 -== **Diagnostic Axes** ==
33 +==== **Diagnostic Axes** ====
35 35  
36 36  * (((
37 37  **Axis 1: Etiology**
... ... @@ -55,11 +55,28 @@
55 55  * //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
56 56  )))
57 57  
58 -== **Applications** ==
57 +==== **Case Studies** ====
59 59  
59 +1. (((
60 +**Sporadic Alzheimer’s Disease**:
61 +
62 +* Axis 1: Sporadic (ApoE4, poor sleep habits).
63 +* Axis 2: Amyloid-beta plaques, elevated NFL.
64 +* Axis 3: Right hippocampus atrophy (visual memory loss).
65 +)))
66 +1. (((
67 +**Genetic Parkinson’s Disease**:
68 +
69 +* Axis 1: Genetic (LRRK2 mutation).
70 +* Axis 2: Alpha-synuclein aggregation.
71 +* Axis 3: Substantia nigra degeneration (motor dysfunction).
72 +)))
73 +
74 +==== **Applications** ====
75 +
60 60  This system enhances:
61 61  
62 -* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
78 +* **Research**: By stratifying patients, it reduces cohort heterogeneity in clinical trials.
63 63  * **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
64 64  
65 65  == Who has access? ==
... ... @@ -66,13 +66,13 @@
66 66  
67 67  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
68 68  
69 -== How to Contribute ==
85 +== How to Contribute: ==
70 70  
71 71  * Access the `/docs` folder for guidelines.
72 72  * Use `/code` for the latest AI pipelines.
73 73  * Share feedback and ideas in the wiki discussion pages.
74 74  
75 -== Key Objectives ==
91 +== Key Objectives: ==
76 76  
77 77  * Develop interpretable AI models for diagnosis and progression tracking.
78 78  * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
... ... @@ -86,7 +86,7 @@
86 86  {{toc/}}
87 87  {{/box}}
88 88  
89 -== Main contents ==
105 +== Main contents: ==
90 90  
91 91  * `/docs`: Documentation and contribution guidelines.
92 92  * `/code`: Machine learning pipelines and scripts.
tridimensional.png
Author
... ... @@ -1,1 +1,0 @@
1 -XWiki.manuelmenendez
Size
... ... @@ -1,1 +1,0 @@
1 -149.8 KB
Content
Collaboratory.Apps.Collab.Code.CollabClass[0]
Public
... ... @@ -1,1 +1,1 @@
1 -Yes
1 +No
XWiki.XWikiRights[3]
Allow/Deny
... ... @@ -1,1 +1,0 @@
1 -Allow
Levels
... ... @@ -1,1 +1,0 @@
1 -view
Users
... ... @@ -1,1 +1,0 @@
1 -XWiki.XWikiGuest
XWiki.XWikiRights[4]
Allow/Deny
... ... @@ -1,1 +1,0 @@
1 -Allow
Groups
... ... @@ -1,1 +1,0 @@
1 -XWiki.XWikiAllGroup
Levels
... ... @@ -1,1 +1,0 @@
1 -view