Changes for page Neurodiagnoses
Last modified by manuelmenendez on 2025/03/03 22:46
From version 15.1
edited by manuelmenendez
on 2025/01/27 23:58
on 2025/01/27 23:58
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To version 5.1
edited by manuelmenendez
on 2025/01/27 23:04
on 2025/01/27 23:04
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... ... @@ -2,10 +2,9 @@ 2 2 ((( 3 3 (% class="container" %) 4 4 ((( 5 -= //A new tridimensionaldiagnostic framework for CNS conditions//=5 += Neurodiagnoses = 6 6 7 -This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies. 8 -We aim to create a structured, interpretable, and scalable diagnostic tool. 7 +This project is focused on developing a novel nosological and diagnostic framework for neurological diseases. Using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies, we aim to create a structured, interpretable, and scalable diagnostic tool. 9 9 ))) 10 10 ))) 11 11 ... ... @@ -13,67 +13,19 @@ 13 13 ((( 14 14 (% class="col-xs-12 col-sm-8" %) 15 15 ((( 16 -= What is this about and whatcan I find here? =15 += What can I find here? = 17 17 18 -== **Overview** == 19 - 20 -The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on: 21 - 22 -* **Axis 1**: Etiology (genetic/sporadic and environmental factors). 23 -* **Axis 2**: Molecular Markers (biomarkers and proteinopathies). 24 -* **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system). 25 - 26 -[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]] 27 - 28 - 29 -This methodology enables: 30 - 31 -* Greater precision in diagnosis. 32 -* Integration of incomplete datasets using AI-driven probabilistic modeling. 33 -* Stratification of patients for personalized treatment. 34 - 35 -== **Diagnostic Axes** == 36 - 37 -* ((( 38 -**Axis 1: Etiology** 39 - 40 -* //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers. 41 -* //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression. 42 -* //Tests//: Genetic testing, lifestyle and cardiovascular screening. 43 -))) 44 -* ((( 45 -**Axis 2: Molecular Markers** 46 - 47 -* //Description//: Analyzes primary (amyloid-beta, tau) and secondary biomarkers (NFL, GFAP) for tracking disease progression. 48 -* //Examples//: CSF amyloid-beta concentrations to confirm Alzheimer’s pathology. 49 -* //Tests//: Blood/CSF biomarkers, PET imaging (Tau-PET, Amyloid-PET). 50 -))) 51 -* ((( 52 -**Axis 3: Neuroanatomoclinical** 53 - 54 -* //Description//: Links clinical symptoms to neuroanatomical changes, such as atrophy or functional impairments. 55 -* //Examples//: Hippocampal atrophy correlating with memory deficits. 56 -* //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations. 57 -))) 58 - 59 -== **Applications** == 60 - 61 -This system enhances: 62 - 63 -* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials. 64 -* **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking. 65 - 66 66 == Who has access? == 67 67 68 68 We welcome contributions from the global community. Let’s build the future of neurological diagnostics together! 69 69 70 -== How to Contribute == 21 +== How to Contribute: == 71 71 72 72 * Access the `/docs` folder for guidelines. 73 73 * Use `/code` for the latest AI pipelines. 74 74 * Share feedback and ideas in the wiki discussion pages. 75 75 76 -== Key Objectives == 27 +== Key Objectives: == 77 77 78 78 * Develop interpretable AI models for diagnosis and progression tracking. 79 79 * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources. ... ... @@ -87,7 +87,7 @@ 87 87 {{toc/}} 88 88 {{/box}} 89 89 90 -== Main contents == 41 +== Main contents: == 91 91 92 92 * `/docs`: Documentation and contribution guidelines. 93 93 * `/code`: Machine learning pipelines and scripts.
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