Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
From version 16.1
edited by manuelmenendez
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To version 6.1
edited by manuelmenendez
on 2025/01/27 23:21
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2 2  (((
3 3  (% class="container" %)
4 4  (((
5 -= //A new tridimensional diagnostic framework for CNS conditions// =
5 += **Neurodiagnoses**
6 +//A new tridimensional diagnostic framework for CNS conditions// =
6 6  
7 7  This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 8  We aim to create a structured, interpretable, and scalable diagnostic tool.
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15 15  (((
16 16  = What is this about and what can I find here? =
17 17  
18 -== **Overview** ==
19 +==== **Overview** ====
19 19  
20 -The //Tridimensional Diagnostic Framework// redefines how CNS conditions are classified by focusing on:
21 +The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
21 21  
22 -* **Axis 1**: Etiology (genetic or other causes of diseases).
23 -* **Axis 2**: Molecular Markers (biomarkers).
23 +* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
24 +* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
24 24  * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 25  
26 -[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
27 -
28 -
29 29  This methodology enables:
30 30  
31 31  * Greater precision in diagnosis.
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32 32  * Integration of incomplete datasets using AI-driven probabilistic modeling.
33 33  * Stratification of patients for personalized treatment.
34 34  
35 -== **Diagnostic Axes** ==
33 +==== **Diagnostic Axes** ====
36 36  
37 37  * (((
38 38  **Axis 1: Etiology**
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56 56  * //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
57 57  )))
58 58  
59 -== **Applications** ==
57 +==== **Case Studies** ====
60 60  
59 +1. (((
60 +**Sporadic Alzheimer’s Disease**:
61 +
62 +* Axis 1: Sporadic (ApoE4, poor sleep habits).
63 +* Axis 2: Amyloid-beta plaques, elevated NFL.
64 +* Axis 3: Right hippocampus atrophy (visual memory loss).
65 +)))
66 +1. (((
67 +**Genetic Parkinson’s Disease**:
68 +
69 +* Axis 1: Genetic (LRRK2 mutation).
70 +* Axis 2: Alpha-synuclein aggregation.
71 +* Axis 3: Substantia nigra degeneration (motor dysfunction).
72 +)))
73 +
74 +==== **Applications** ====
75 +
61 61  This system enhances:
62 62  
63 -* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
78 +* **Research**: By stratifying patients, it reduces cohort heterogeneity in clinical trials.
64 64  * **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
65 65  
66 66  == Who has access? ==
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67 67  
68 68  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
69 69  
70 -== How to Contribute ==
85 +== How to Contribute: ==
71 71  
72 72  * Access the `/docs` folder for guidelines.
73 73  * Use `/code` for the latest AI pipelines.
74 74  * Share feedback and ideas in the wiki discussion pages.
75 75  
76 -== Key Objectives ==
91 +== Key Objectives: ==
77 77  
78 78  * Develop interpretable AI models for diagnosis and progression tracking.
79 79  * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
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87 87  {{toc/}}
88 88  {{/box}}
89 89  
90 -== Main contents ==
105 +== Main contents: ==
91 91  
92 92  * `/docs`: Documentation and contribution guidelines.
93 93  * `/code`: Machine learning pipelines and scripts.
tridimensional.png
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