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5		-= //A new tridimensional diagnostic framework for neurodegenerative diseases// =
	5	+= //A new tridimensional diagnostic framework for CNS conditions// =
6	6
7	7	This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8	8	We aim to create a structured, interpretable, and scalable diagnostic tool.
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15	15	(((
16	16	= What is this about and what can I find here? =
17	17
18		-== **Overview** ==
	18	+==== **Overview** ====
19	19
20		-The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDD) are classified by focusing on:
	20	+The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
21	21
22		-* **Axis 1**: Etiology (genetic or other causes of diseases).
23		-* **Axis 2**: Molecular Markers (biomarkers).
	22	+* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
	23	+* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
24	24	* **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25	25
26		-[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
27		-
28		-
29	29	This methodology enables:
30	30
31	31	* Greater precision in diagnosis.
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32	32	* Integration of incomplete datasets using AI-driven probabilistic modeling.
33	33	* Stratification of patients for personalized treatment.
34	34
35		-== **Diagnostic Axes** ==
	32	+==== **Diagnostic Axes** ====
36	36
37	37	* (((
38	38	**Axis 1: Etiology**
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56	56	* //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
57	57	)))
58	58
59		-== **Applications** ==
	56	+==== **Applications** ====
60	60
61	61	This system enhances:
62	62
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67	67
68	68	We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
69	69
70		-== How to Contribute ==
	67	+== How to Contribute: ==
71	71
72	72	* Access the `/docs` folder for guidelines.
73	73	* Use `/code` for the latest AI pipelines.
74	74	* Share feedback and ideas in the wiki discussion pages.
75	75
76		-== Key Objectives ==
	73	+== Key Objectives: ==
77	77
78	78	* Develop interpretable AI models for diagnosis and progression tracking.
79	79	* Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
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87	87	{{toc/}}
88	88	{{/box}}
89	89
90		-== Main contents ==
	87	+== Main contents: ==
91	91
92	92	* `/docs`: Documentation and contribution guidelines.
93	93	* `/code`: Machine learning pipelines and scripts.

tridimensional.png

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