Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
From version 2.1
edited by manuelmenendez
on 2025/01/27 22:53
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To version 8.1
edited by manuelmenendez
on 2025/01/27 23:22
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5 -= My Collab's Extended Title =
5 += //A new tridimensional diagnostic framework for CNS conditions// =
6 6  
7 -My collab's subtitle
7 +This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 +We aim to create a structured, interpretable, and scalable diagnostic tool.
8 8  )))
9 9  )))
10 10  
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15 -= What can I find here? =
16 += What is this about and what can I find here? =
16 16  
17 -* Notice how the table of contents on the right
18 -* is automatically updated
19 -* to hold this page's headers
18 +==== **Overview** ====
20 20  
21 -= Who has access? =
20 +The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
22 22  
23 -Describe the audience of this collab.
22 +* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
23 +* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
24 +* **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 +
26 +This methodology enables:
27 +
28 +* Greater precision in diagnosis.
29 +* Integration of incomplete datasets using AI-driven probabilistic modeling.
30 +* Stratification of patients for personalized treatment.
31 +
32 +==== **Diagnostic Axes** ====
33 +
34 +* (((
35 +**Axis 1: Etiology**
36 +
37 +* //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers.
38 +* //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression.
39 +* //Tests//: Genetic testing, lifestyle and cardiovascular screening.
24 24  )))
41 +* (((
42 +**Axis 2: Molecular Markers**
25 25  
44 +* //Description//: Analyzes primary (amyloid-beta, tau) and secondary biomarkers (NFL, GFAP) for tracking disease progression.
45 +* //Examples//: CSF amyloid-beta concentrations to confirm Alzheimer’s pathology.
46 +* //Tests//: Blood/CSF biomarkers, PET imaging (Tau-PET, Amyloid-PET).
47 +)))
48 +* (((
49 +**Axis 3: Neuroanatomoclinical**
26 26  
51 +* //Description//: Links clinical symptoms to neuroanatomical changes, such as atrophy or functional impairments.
52 +* //Examples//: Hippocampal atrophy correlating with memory deficits.
53 +* //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
54 +)))
55 +
56 +==== **Applications** ====
57 +
58 +This system enhances:
59 +
60 +* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
61 +* **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
62 +
63 +== Who has access? ==
64 +
65 +We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
66 +
67 +== How to Contribute: ==
68 +
69 +* Access the `/docs` folder for guidelines.
70 +* Use `/code` for the latest AI pipelines.
71 +* Share feedback and ideas in the wiki discussion pages.
72 +
73 +== Key Objectives: ==
74 +
75 +* Develop interpretable AI models for diagnosis and progression tracking.
76 +* Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
77 +* Foster collaboration among neuroscientists, AI researchers, and clinicians.
78 +)))
79 +
80 +
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28 28  (((
29 29  {{box title="**Contents**"}}
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30 30  {{toc/}}
31 31  {{/box}}
32 32  
33 -
87 +== Main contents: ==
88 +
89 +* `/docs`: Documentation and contribution guidelines.
90 +* `/code`: Machine learning pipelines and scripts.
91 +* `/data`: Sample datasets for testing.
92 +* `/outputs`: Generated models, visualizations, and reports.
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35 35  )))
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