Changes for page Neurodiagnoses
Last modified by manuelmenendez on 2025/03/03 22:46
From version 20.1
edited by manuelmenendez
on 2025/01/28 00:03
on 2025/01/28 00:03
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To version 26.1
edited by manuelmenendez
on 2025/01/29 18:48
on 2025/01/29 18:48
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... ... @@ -2,9 +2,9 @@ 2 2 ((( 3 3 (% class="container" %) 4 4 ((( 5 -= //A new tridimensional diagnostic framework for neurodegenerativediseases// =5 += //A new tridimensional diagnostic framework for CNS diseases// = 6 6 7 -This project is focused on developing a novel nosological and diagnostic framework for neurodegenerativediseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.7 +This project is focused on developing a novel nosological and diagnostic framework for CNS diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies. 8 8 We aim to create a structured, interpretable, and scalable diagnostic tool. 9 9 ))) 10 10 ))) ... ... @@ -17,16 +17,12 @@ 17 17 18 18 == **Overview** == 19 19 20 -The //Tridimensional Diagnostic Framework// redefines howneurodegenerative diseases(NDD)are classified by focusing on:20 +The //Tridimensional Diagnostic Framework// redefines CNS diseases can be classified and diagnosed by focusing on: 21 21 22 22 * **Axis 1**: Etiology (genetic or other causes of diseases). 23 23 * **Axis 2**: Molecular Markers (biomarkers). 24 24 * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system). 25 25 26 - 27 -[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]] 28 - 29 - 30 30 This methodology enables: 31 31 32 32 * Greater precision in diagnosis. ... ... @@ -33,14 +33,18 @@ 33 33 * Integration of incomplete datasets using AI-driven probabilistic modeling. 34 34 * Stratification of patients for personalized treatment. 35 35 36 -== ** DiagnosticAxes** ==32 +== **The case of neurodegenerative diseases** == 37 37 34 +There have been described these 3 diagnostic axes: 35 + 36 +[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]] 37 + 38 38 * ((( 39 39 **Axis 1: Etiology** 40 40 41 41 * //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers. 42 42 * //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression. 43 -* //Tests//: Genetic testing, lifestyle and cardiovascular screening. 43 +* //Tests//: Genetic testing, lifestyle, and cardiovascular screening. 44 44 ))) 45 45 * ((( 46 46 **Axis 2: Molecular Markers** ... ... @@ -82,6 +82,8 @@ 82 82 ))) 83 83 84 84 85 + 86 + 85 85 (% class="col-xs-12 col-sm-4" %) 86 86 ((( 87 87 {{box title="**Contents**"}} ... ... @@ -94,5 +94,8 @@ 94 94 * `/code`: Machine learning pipelines and scripts. 95 95 * `/data`: Sample datasets for testing. 96 96 * `/outputs`: Generated models, visualizations, and reports. 99 +* [[Methodology>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Methodology/]] 100 +* [[Results>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Results/]] 101 +* [[to-do-list>>to-do-list]] 97 97 ))) 98 98 )))