Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
From version 20.1
edited by manuelmenendez
on 2025/01/28 00:03
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To version 6.1
edited by manuelmenendez
on 2025/01/27 23:21
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2 2  (((
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4 4  (((
5 -= //A new tridimensional diagnostic framework for neurodegenerative diseases// =
5 += **Neurodiagnoses**
6 +//A new tridimensional diagnostic framework for CNS conditions// =
6 6  
7 -This project is focused on developing a novel nosological and diagnostic framework for neurodegenerative diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 +This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 8  We aim to create a structured, interpretable, and scalable diagnostic tool.
9 9  )))
10 10  )))
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15 15  (((
16 16  = What is this about and what can I find here? =
17 17  
18 -== **Overview** ==
19 +==== **Overview** ====
19 19  
20 -The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDD) are classified by focusing on:
21 +The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
21 21  
22 -* **Axis 1**: Etiology (genetic or other causes of diseases).
23 -* **Axis 2**: Molecular Markers (biomarkers).
23 +* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
24 +* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
24 24  * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 25  
26 -
27 -[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
28 -
29 -
30 30  This methodology enables:
31 31  
32 32  * Greater precision in diagnosis.
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33 33  * Integration of incomplete datasets using AI-driven probabilistic modeling.
34 34  * Stratification of patients for personalized treatment.
35 35  
36 -== **Diagnostic Axes** ==
33 +==== **Diagnostic Axes** ====
37 37  
38 38  * (((
39 39  **Axis 1: Etiology**
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57 57  * //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
58 58  )))
59 59  
60 -== **Applications** ==
57 +==== **Case Studies** ====
61 61  
59 +1. (((
60 +**Sporadic Alzheimer’s Disease**:
61 +
62 +* Axis 1: Sporadic (ApoE4, poor sleep habits).
63 +* Axis 2: Amyloid-beta plaques, elevated NFL.
64 +* Axis 3: Right hippocampus atrophy (visual memory loss).
65 +)))
66 +1. (((
67 +**Genetic Parkinson’s Disease**:
68 +
69 +* Axis 1: Genetic (LRRK2 mutation).
70 +* Axis 2: Alpha-synuclein aggregation.
71 +* Axis 3: Substantia nigra degeneration (motor dysfunction).
72 +)))
73 +
74 +==== **Applications** ====
75 +
62 62  This system enhances:
63 63  
64 -* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
78 +* **Research**: By stratifying patients, it reduces cohort heterogeneity in clinical trials.
65 65  * **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
66 66  
67 67  == Who has access? ==
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68 68  
69 69  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
70 70  
71 -== How to Contribute ==
85 +== How to Contribute: ==
72 72  
73 73  * Access the `/docs` folder for guidelines.
74 74  * Use `/code` for the latest AI pipelines.
75 75  * Share feedback and ideas in the wiki discussion pages.
76 76  
77 -== Key Objectives ==
91 +== Key Objectives: ==
78 78  
79 79  * Develop interpretable AI models for diagnosis and progression tracking.
80 80  * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
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88 88  {{toc/}}
89 89  {{/box}}
90 90  
91 -== Main contents ==
105 +== Main contents: ==
92 92  
93 93  * `/docs`: Documentation and contribution guidelines.
94 94  * `/code`: Machine learning pipelines and scripts.
tridimensional.png
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