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Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
From version 21.1
edited by manuelmenendez
on 2025/01/28 00:30
Change comment: There is no comment for this version
To version 9.1
edited by manuelmenendez
on 2025/01/27 23:23
Change comment: There is no comment for this version

Summary

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5 -= //A new tridimensional diagnostic framework for neurodegenerative diseases// =
5 += //A new tridimensional diagnostic framework for CNS conditions// =
6 6  
7 -This project is focused on developing a novel nosological and diagnostic framework for neurodegenerative diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
7 +This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 8  We aim to create a structured, interpretable, and scalable diagnostic tool.
9 9  )))
10 10  )))
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17 17  
18 18  == **Overview** ==
19 19  
20 -The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDD) are classified by focusing on:
20 +The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
21 21  
22 -* **Axis 1**: Etiology (genetic or other causes of diseases).
23 -* **Axis 2**: Molecular Markers (biomarkers).
22 +* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
23 +* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
24 24  * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 25  
26 -[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
27 -
28 -
29 29  This methodology enables:
30 30  
31 31  * Greater precision in diagnosis.
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67 67  
68 68  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
69 69  
70 -== How to Contribute ==
67 +== How to Contribute: ==
71 71  
72 72  * Access the `/docs` folder for guidelines.
73 73  * Use `/code` for the latest AI pipelines.
74 74  * Share feedback and ideas in the wiki discussion pages.
75 75  
76 -== Key Objectives ==
73 +== Key Objectives: ==
77 77  
78 78  * Develop interpretable AI models for diagnosis and progression tracking.
79 79  * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
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87 87  {{toc/}}
88 88  {{/box}}
89 89  
90 -== Main contents ==
87 +== Main contents: ==
91 91  
92 92  * `/docs`: Documentation and contribution guidelines.
93 93  * `/code`: Machine learning pipelines and scripts.
94 94  * `/data`: Sample datasets for testing.
95 95  * `/outputs`: Generated models, visualizations, and reports.
96 -* [[Methodology>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Methodology/]]
97 -* [[Results>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Results/]]
98 98  )))
99 99  )))
tridimensional.png
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