Changes for page Neurodiagnoses
Last modified by manuelmenendez on 2025/03/03 22:46
From version 23.1
edited by manuelmenendez
on 2025/01/29 18:46
on 2025/01/29 18:46
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To version 9.1
edited by manuelmenendez
on 2025/01/27 23:23
on 2025/01/27 23:23
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... ... @@ -2,9 +2,9 @@ 2 2 ((( 3 3 (% class="container" %) 4 4 ((( 5 -= //A new tridimensional diagnostic framework for CNS dis eases// =5 += //A new tridimensional diagnostic framework for CNS conditions// = 6 6 7 -This project is focused on developing a novel nosological and diagnostic framework for CNSdiseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.7 +This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies. 8 8 We aim to create a structured, interpretable, and scalable diagnostic tool. 9 9 ))) 10 10 ))) ... ... @@ -17,15 +17,12 @@ 17 17 18 18 == **Overview** == 19 19 20 -The //Tridimensional Diagnostic Framework// redefines CNSdiseasescanbe classifiedand diagnosedby focusing on:20 +The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on: 21 21 22 -* **Axis 1**: Etiology (genetic othercausesofdiseases).23 -* **Axis 2**: Molecular Markers (biomarkers). 22 +* **Axis 1**: Etiology (genetic/sporadic and environmental factors). 23 +* **Axis 2**: Molecular Markers (biomarkers and proteinopathies). 24 24 * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system). 25 25 26 -[[For instance, neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]] 27 - 28 - 29 29 This methodology enables: 30 30 31 31 * Greater precision in diagnosis. ... ... @@ -32,16 +32,14 @@ 32 32 * Integration of incomplete datasets using AI-driven probabilistic modeling. 33 33 * Stratification of patients for personalized treatment. 34 34 35 -== ** The case of neurodegenerativediseases** ==32 +== **Diagnostic Axes** == 36 36 37 -There have been described these 3 diagnostic axes: 38 - 39 39 * ((( 40 40 **Axis 1: Etiology** 41 41 42 42 * //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers. 43 43 * //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression. 44 -* //Tests//: Genetic testing, lifestyle ,and cardiovascular screening.39 +* //Tests//: Genetic testing, lifestyle and cardiovascular screening. 45 45 ))) 46 46 * ((( 47 47 **Axis 2: Molecular Markers** ... ... @@ -69,13 +69,13 @@ 69 69 70 70 We welcome contributions from the global community. Let’s build the future of neurological diagnostics together! 71 71 72 -== How to Contribute == 67 +== How to Contribute: == 73 73 74 74 * Access the `/docs` folder for guidelines. 75 75 * Use `/code` for the latest AI pipelines. 76 76 * Share feedback and ideas in the wiki discussion pages. 77 77 78 -== Key Objectives == 73 +== Key Objectives: == 79 79 80 80 * Develop interpretable AI models for diagnosis and progression tracking. 81 81 * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources. ... ... @@ -89,14 +89,11 @@ 89 89 {{toc/}} 90 90 {{/box}} 91 91 92 -== Main contents == 87 +== Main contents: == 93 93 94 94 * `/docs`: Documentation and contribution guidelines. 95 95 * `/code`: Machine learning pipelines and scripts. 96 96 * `/data`: Sample datasets for testing. 97 97 * `/outputs`: Generated models, visualizations, and reports. 98 -* [[Methodology>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Methodology/]] 99 -* [[Results>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Results/]] 100 -* [[to-do-list>>to-do-list]] 101 101 ))) 102 102 )))
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