Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
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edited by manuelmenendez
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edited by manuelmenendez
on 2025/01/27 23:23
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2 2  (((
3 3  (% class="container" %)
4 4  (((
5 -= //A new tridimensional diagnostic framework for CNS diseases// =
5 += //A new tridimensional diagnostic framework for CNS conditions// =
6 6  
7 -This project is focused on developing a novel nosological and diagnostic framework for CNS diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
7 +This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 8  We aim to create a structured, interpretable, and scalable diagnostic tool.
9 9  )))
10 10  )))
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17 17  
18 18  == **Overview** ==
19 19  
20 -The //Tridimensional Diagnostic Framework// redefines CNS diseases can be classified and diagnosed by focusing on:
20 +The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
21 21  
22 -* **Axis 1**: Etiology (genetic or other causes of diseases).
23 -* **Axis 2**: Molecular Markers (biomarkers).
22 +* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
23 +* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
24 24  * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 25  
26 -[[For instance, neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
27 -
28 -
29 29  This methodology enables:
30 30  
31 31  * Greater precision in diagnosis.
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32 32  * Integration of incomplete datasets using AI-driven probabilistic modeling.
33 33  * Stratification of patients for personalized treatment.
34 34  
35 -== **The case of neurodegenerative diseases** ==
32 +== **Diagnostic Axes** ==
36 36  
37 -There have been described these 3 diagnostic axes:
38 -
39 39  * (((
40 40  **Axis 1: Etiology**
41 41  
42 42  * //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers.
43 43  * //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression.
44 -* //Tests//: Genetic testing, lifestyle, and cardiovascular screening.
39 +* //Tests//: Genetic testing, lifestyle and cardiovascular screening.
45 45  )))
46 46  * (((
47 47  **Axis 2: Molecular Markers**
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69 69  
70 70  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
71 71  
72 -== How to Contribute ==
67 +== How to Contribute: ==
73 73  
74 74  * Access the `/docs` folder for guidelines.
75 75  * Use `/code` for the latest AI pipelines.
76 76  * Share feedback and ideas in the wiki discussion pages.
77 77  
78 -== Key Objectives ==
73 +== Key Objectives: ==
79 79  
80 80  * Develop interpretable AI models for diagnosis and progression tracking.
81 81  * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
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89 89  {{toc/}}
90 90  {{/box}}
91 91  
92 -== Main contents ==
87 +== Main contents: ==
93 93  
94 94  * `/docs`: Documentation and contribution guidelines.
95 95  * `/code`: Machine learning pipelines and scripts.
96 96  * `/data`: Sample datasets for testing.
97 97  * `/outputs`: Generated models, visualizations, and reports.
98 -* [[Methodology>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Methodology/]]
99 -* [[Results>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Results/]]
100 -* [[to-do-list>>to-do-list]]
101 101  )))
102 102  )))
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