Changes for page Neurodiagnoses
Last modified by manuelmenendez on 2025/03/03 22:46
From version 25.1
edited by manuelmenendez
on 2025/01/29 18:47
on 2025/01/29 18:47
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To version 33.1
edited by manuelmenendez
on 2025/02/01 13:54
on 2025/02/01 13:54
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... ... @@ -15,8 +15,20 @@ 15 15 ((( 16 16 = What is this about and what can I find here? = 17 17 18 -= =**Overview** ==18 += **Overview** = 19 19 20 +T 21 + 22 +The classification and diagnosis of **central nervous system (CNS) diseases** have long been constrained by **traditional phenotype-based approaches**, which often fail to capture the **complex pathophysiological mechanisms, molecular biomarkers, and neuroanatomical changes** that drive disease progression. **Neurodegenerative and psychiatric disorders**, for example, exhibit significant **clinical overlap, co-pathology, and heterogeneity**, making current diagnostic models insufficient. 23 + 24 +This project proposes a **new diagnostic framework**—one that **shifts from symptom-based classifications** to an **etiology-driven, tridimensional system**. By integrating **genetics, proteomics, neuroimaging, computational modeling, and AI-powered annotations**, this approach aims to provide a **more precise, scalable, and biologically grounded method for diagnosing and managing CNS diseases**. 25 + 26 +The **AI-powered annotation system** plays a critical role by **structuring, interpreting, and tracking multi-modal data**, ensuring **real-time disease progression analysis, clinician decision support, and personalized treatment pathways**. 27 + 28 +=== **Project Aim** === 29 + 30 +The project aims to develop a **tridimensional diagnostic framework** with an **AI-powered annotation system**, integrating **etiology, molecular biomarkers, and neuroanatomoclinical correlations** for **precise, standardized, and scalable CNS disease diagnostics**. 31 + 20 20 The //Tridimensional Diagnostic Framework// redefines CNS diseases can be classified and diagnosed by focusing on: 21 21 22 22 * **Axis 1**: Etiology (genetic or other causes of diseases). ... ... @@ -23,7 +23,6 @@ 23 23 * **Axis 2**: Molecular Markers (biomarkers). 24 24 * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system). 25 25 26 - 27 27 This methodology enables: 28 28 29 29 * Greater precision in diagnosis. ... ... @@ -30,6 +30,16 @@ 30 30 * Integration of incomplete datasets using AI-driven probabilistic modeling. 31 31 * Stratification of patients for personalized treatment. 32 32 44 +== **The Role of AI-Powered Annotation** == 45 + 46 +To enhance **standardization, interpretability, and clinical application**, the framework integrates **an AI-powered annotation system**, which: 47 + 48 +* **Assigns structured metadata tags** to diagnostic features. 49 +* **Provides real-time contextual explanations** for AI-based classifications. 50 +* **Tracks longitudinal disease progression** using timestamped AI annotations. 51 +* **Improves AI model transparency** through interpretability tools (e.g., SHAP analysis). 52 +* **Facilitates decision-making for clinicians** by linking annotations to standardized biomedical ontologies (SNOMED, HPO). 53 + 33 33 == **The case of neurodegenerative diseases** == 34 34 35 35 There have been described these 3 diagnostic axes: ... ... @@ -65,10 +65,6 @@ 65 65 * **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials. 66 66 * **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking. 67 67 68 -== Who has access? == 69 - 70 -We welcome contributions from the global community. Let’s build the future of neurological diagnostics together! 71 - 72 72 == How to Contribute == 73 73 74 74 * Access the `/docs` folder for guidelines. ... ... @@ -80,9 +80,17 @@ 80 80 * Develop interpretable AI models for diagnosis and progression tracking. 81 81 * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources. 82 82 * Foster collaboration among neuroscientists, AI researchers, and clinicians. 100 + 101 +== Who has access? == 102 + 103 +We welcome contributions from the global community. Let’s build the future of neurological diagnostics together! 83 83 ))) 84 84 85 85 107 + 108 + 109 + 110 + 86 86 (% class="col-xs-12 col-sm-4" %) 87 87 ((( 88 88 {{box title="**Contents**"}}