Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46

From version 25.1
edited by manuelmenendez
on 2025/01/29 18:47
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To version 33.1
edited by manuelmenendez
on 2025/02/01 13:54
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15 15  (((
16 16  = What is this about and what can I find here? =
17 17  
18 -== **Overview** ==
18 += **Overview** =
19 19  
20 +T
21 +
22 +The classification and diagnosis of **central nervous system (CNS) diseases** have long been constrained by **traditional phenotype-based approaches**, which often fail to capture the **complex pathophysiological mechanisms, molecular biomarkers, and neuroanatomical changes** that drive disease progression. **Neurodegenerative and psychiatric disorders**, for example, exhibit significant **clinical overlap, co-pathology, and heterogeneity**, making current diagnostic models insufficient.
23 +
24 +This project proposes a **new diagnostic framework**—one that **shifts from symptom-based classifications** to an **etiology-driven, tridimensional system**. By integrating **genetics, proteomics, neuroimaging, computational modeling, and AI-powered annotations**, this approach aims to provide a **more precise, scalable, and biologically grounded method for diagnosing and managing CNS diseases**.
25 +
26 +The **AI-powered annotation system** plays a critical role by **structuring, interpreting, and tracking multi-modal data**, ensuring **real-time disease progression analysis, clinician decision support, and personalized treatment pathways**.
27 +
28 +=== **Project Aim** ===
29 +
30 +The project aims to develop a **tridimensional diagnostic framework** with an **AI-powered annotation system**, integrating **etiology, molecular biomarkers, and neuroanatomoclinical correlations** for **precise, standardized, and scalable CNS disease diagnostics**.
31 +
20 20  The //Tridimensional Diagnostic Framework// redefines CNS diseases can be classified and diagnosed by focusing on:
21 21  
22 22  * **Axis 1**: Etiology (genetic or other causes of diseases).
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23 23  * **Axis 2**: Molecular Markers (biomarkers).
24 24  * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 25  
26 -
27 27  This methodology enables:
28 28  
29 29  * Greater precision in diagnosis.
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30 30  * Integration of incomplete datasets using AI-driven probabilistic modeling.
31 31  * Stratification of patients for personalized treatment.
32 32  
44 +== **The Role of AI-Powered Annotation** ==
45 +
46 +To enhance **standardization, interpretability, and clinical application**, the framework integrates **an AI-powered annotation system**, which:
47 +
48 +* **Assigns structured metadata tags** to diagnostic features.
49 +* **Provides real-time contextual explanations** for AI-based classifications.
50 +* **Tracks longitudinal disease progression** using timestamped AI annotations.
51 +* **Improves AI model transparency** through interpretability tools (e.g., SHAP analysis).
52 +* **Facilitates decision-making for clinicians** by linking annotations to standardized biomedical ontologies (SNOMED, HPO).
53 +
33 33  == **The case of neurodegenerative diseases** ==
34 34  
35 35  There have been described these 3 diagnostic axes:
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65 65  * **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
66 66  * **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
67 67  
68 -== Who has access? ==
69 -
70 -We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
71 -
72 72  == How to Contribute ==
73 73  
74 74  * Access the `/docs` folder for guidelines.
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80 80  * Develop interpretable AI models for diagnosis and progression tracking.
81 81  * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
82 82  * Foster collaboration among neuroscientists, AI researchers, and clinicians.
100 +
101 +== Who has access? ==
102 +
103 +We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
83 83  )))
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87 87  (((
88 88  {{box title="**Contents**"}}