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2	2	(((
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4	4	(((
5		-= //A new tridimensional diagnostic framework for CNS diseases// =
	5	+= **Neurodiagnoses**
	6	+//A new tridimensional diagnostic framework for CNS conditions// =
6	6
7		-This project is focused on developing a novel nosological and diagnostic framework for CNS diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
	8	+This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8	8	We aim to create a structured, interpretable, and scalable diagnostic tool.
9	9	)))
10	10	)))
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15	15	(((
16	16	= What is this about and what can I find here? =
17	17
18		-= **Overview** =
	19	+==== **Overview** ====
19	19
20		-The //Tridimensional Diagnostic Framework// redefines CNS diseases can be classified and diagnosed by focusing on:
	21	+The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
21	21
22		-* **Axis 1**: Etiology (genetic or other causes of diseases).
23		-* **Axis 2**: Molecular Markers (biomarkers).
	23	+* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
	24	+* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
24	24	* **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25	25
26	26	This methodology enables:
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29	29	* Integration of incomplete datasets using AI-driven probabilistic modeling.
30	30	* Stratification of patients for personalized treatment.
31	31
32		-== **The case of neurodegenerative diseases** ==
	33	+==== **Diagnostic Axes** ====
33	33
34		-There have been described these 3 diagnostic axes:
35		-
36		-[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
37		-
38	38	* (((
39	39	**Axis 1: Etiology**
40	40
41	41	* //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers.
42	42	* //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression.
43		-* //Tests//: Genetic testing, lifestyle, and cardiovascular screening.
	40	+* //Tests//: Genetic testing, lifestyle and cardiovascular screening.
44	44	)))
45	45	* (((
46	46	**Axis 2: Molecular Markers**
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57	57	* //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
58	58	)))
59	59
60		-== **Applications** ==
	57	+==== **Case Studies** ====
61	61
	59	+1. (((
	60	+**Sporadic Alzheimer’s Disease**:
	61	+
	62	+* Axis 1: Sporadic (ApoE4, poor sleep habits).
	63	+* Axis 2: Amyloid-beta plaques, elevated NFL.
	64	+* Axis 3: Right hippocampus atrophy (visual memory loss).
	65	+)))
	66	+1. (((
	67	+**Genetic Parkinson’s Disease**:
	68	+
	69	+* Axis 1: Genetic (LRRK2 mutation).
	70	+* Axis 2: Alpha-synuclein aggregation.
	71	+* Axis 3: Substantia nigra degeneration (motor dysfunction).
	72	+)))
	73	+
	74	+==== **Applications** ====
	75	+
62	62	This system enhances:
63	63
64		-* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
	78	+* **Research**: By stratifying patients, it reduces cohort heterogeneity in clinical trials.
65	65	* **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
66	66
67	67	== Who has access? ==
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68	68
69	69	We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
70	70
71		-== How to Contribute ==
	85	+== How to Contribute: ==
72	72
73	73	* Access the `/docs` folder for guidelines.
74	74	* Use `/code` for the latest AI pipelines.
75	75	* Share feedback and ideas in the wiki discussion pages.
76	76
77		-== Key Objectives ==
	91	+== Key Objectives: ==
78	78
79	79	* Develop interpretable AI models for diagnosis and progression tracking.
80	80	* Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
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82	82	)))
83	83
84	84
85		-
86		-
87		-
88	88	(% class="col-xs-12 col-sm-4" %)
89	89	(((
90	90	{{box title="**Contents**"}}
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91	91	{{toc/}}
92	92	{{/box}}
93	93
94		-== Main contents ==
	105	+== Main contents: ==
95	95
96	96	* `/docs`: Documentation and contribution guidelines.
97	97	* `/code`: Machine learning pipelines and scripts.
98	98	* `/data`: Sample datasets for testing.
99	99	* `/outputs`: Generated models, visualizations, and reports.
100		-* [[Methodology>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Methodology/]]
101		-* [[Results>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Results/]]
102		-* [[to-do-list>>to-do-list]]
103	103	)))
104	104	)))

tridimensional.png

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