Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46

From version 33.1
edited by manuelmenendez
on 2025/02/01 13:54
Change comment: There is no comment for this version
To version 20.1
edited by manuelmenendez
on 2025/01/28 00:03
Change comment: There is no comment for this version

Summary

Details

Page properties
Content
... ... @@ -2,9 +2,9 @@
2 2  (((
3 3  (% class="container" %)
4 4  (((
5 -= //A new tridimensional diagnostic framework for CNS diseases// =
5 += //A new tridimensional diagnostic framework for neurodegenerative diseases// =
6 6  
7 -This project is focused on developing a novel nosological and diagnostic framework for CNS diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
7 +This project is focused on developing a novel nosological and diagnostic framework for neurodegenerative diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 8  We aim to create a structured, interpretable, and scalable diagnostic tool.
9 9  )))
10 10  )))
... ... @@ -15,26 +15,18 @@
15 15  (((
16 16  = What is this about and what can I find here? =
17 17  
18 -= **Overview** =
18 +== **Overview** ==
19 19  
20 -T
20 +The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDD) are classified by focusing on:
21 21  
22 -The classification and diagnosis of **central nervous system (CNS) diseases** have long been constrained by **traditional phenotype-based approaches**, which often fail to capture the **complex pathophysiological mechanisms, molecular biomarkers, and neuroanatomical changes** that drive disease progression. **Neurodegenerative and psychiatric disorders**, for example, exhibit significant **clinical overlap, co-pathology, and heterogeneity**, making current diagnostic models insufficient.
23 -
24 -This project proposes a **new diagnostic framework**—one that **shifts from symptom-based classifications** to an **etiology-driven, tridimensional system**. By integrating **genetics, proteomics, neuroimaging, computational modeling, and AI-powered annotations**, this approach aims to provide a **more precise, scalable, and biologically grounded method for diagnosing and managing CNS diseases**.
25 -
26 -The **AI-powered annotation system** plays a critical role by **structuring, interpreting, and tracking multi-modal data**, ensuring **real-time disease progression analysis, clinician decision support, and personalized treatment pathways**.
27 -
28 -=== **Project Aim** ===
29 -
30 -The project aims to develop a **tridimensional diagnostic framework** with an **AI-powered annotation system**, integrating **etiology, molecular biomarkers, and neuroanatomoclinical correlations** for **precise, standardized, and scalable CNS disease diagnostics**.
31 -
32 -The //Tridimensional Diagnostic Framework// redefines CNS diseases can be classified and diagnosed by focusing on:
33 -
34 34  * **Axis 1**: Etiology (genetic or other causes of diseases).
35 35  * **Axis 2**: Molecular Markers (biomarkers).
36 36  * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
37 37  
26 +
27 +[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
28 +
29 +
38 38  This methodology enables:
39 39  
40 40  * Greater precision in diagnosis.
... ... @@ -41,28 +41,14 @@
41 41  * Integration of incomplete datasets using AI-driven probabilistic modeling.
42 42  * Stratification of patients for personalized treatment.
43 43  
44 -== **The Role of AI-Powered Annotation** ==
36 +== **Diagnostic Axes** ==
45 45  
46 -To enhance **standardization, interpretability, and clinical application**, the framework integrates **an AI-powered annotation system**, which:
47 -
48 -* **Assigns structured metadata tags** to diagnostic features.
49 -* **Provides real-time contextual explanations** for AI-based classifications.
50 -* **Tracks longitudinal disease progression** using timestamped AI annotations.
51 -* **Improves AI model transparency** through interpretability tools (e.g., SHAP analysis).
52 -* **Facilitates decision-making for clinicians** by linking annotations to standardized biomedical ontologies (SNOMED, HPO).
53 -
54 -== **The case of neurodegenerative diseases** ==
55 -
56 -There have been described these 3 diagnostic axes:
57 -
58 -[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
59 -
60 60  * (((
61 61  **Axis 1: Etiology**
62 62  
63 63  * //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers.
64 64  * //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression.
65 -* //Tests//: Genetic testing, lifestyle, and cardiovascular screening.
43 +* //Tests//: Genetic testing, lifestyle and cardiovascular screening.
66 66  )))
67 67  * (((
68 68  **Axis 2: Molecular Markers**
... ... @@ -86,6 +86,10 @@
86 86  * **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
87 87  * **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
88 88  
67 +== Who has access? ==
68 +
69 +We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
70 +
89 89  == How to Contribute ==
90 90  
91 91  * Access the `/docs` folder for guidelines.
... ... @@ -97,17 +97,9 @@
97 97  * Develop interpretable AI models for diagnosis and progression tracking.
98 98  * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
99 99  * Foster collaboration among neuroscientists, AI researchers, and clinicians.
100 -
101 -== Who has access? ==
102 -
103 -We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
104 104  )))
105 105  
106 106  
107 -
108 -
109 -
110 -
111 111  (% class="col-xs-12 col-sm-4" %)
112 112  (((
113 113  {{box title="**Contents**"}}
... ... @@ -120,8 +120,5 @@
120 120  * `/code`: Machine learning pipelines and scripts.
121 121  * `/data`: Sample datasets for testing.
122 122  * `/outputs`: Generated models, visualizations, and reports.
123 -* [[Methodology>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Methodology/]]
124 -* [[Results>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Results/]]
125 -* [[to-do-list>>to-do-list]]
126 126  )))
127 127  )))