Changes for page Neurodiagnoses
Last modified by manuelmenendez on 2025/03/03 22:46
From version 34.1
edited by manuelmenendez
on 2025/02/01 13:54
on 2025/02/01 13:54
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To version 26.1
edited by manuelmenendez
on 2025/01/29 18:48
on 2025/01/29 18:48
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... ... @@ -15,19 +15,8 @@ 15 15 ((( 16 16 = What is this about and what can I find here? = 17 17 18 -= **Overview** = 18 +== **Overview** == 19 19 20 - 21 -The classification and diagnosis of **central nervous system (CNS) diseases** have long been constrained by **traditional phenotype-based approaches**, which often fail to capture the **complex pathophysiological mechanisms, molecular biomarkers, and neuroanatomical changes** that drive disease progression. **Neurodegenerative and psychiatric disorders**, for example, exhibit significant **clinical overlap, co-pathology, and heterogeneity**, making current diagnostic models insufficient. 22 - 23 -This project proposes a **new diagnostic framework**—one that **shifts from symptom-based classifications** to an **etiology-driven, tridimensional system**. By integrating **genetics, proteomics, neuroimaging, computational modeling, and AI-powered annotations**, this approach aims to provide a **more precise, scalable, and biologically grounded method for diagnosing and managing CNS diseases**. 24 - 25 -The **AI-powered annotation system** plays a critical role by **structuring, interpreting, and tracking multi-modal data**, ensuring **real-time disease progression analysis, clinician decision support, and personalized treatment pathways**. 26 - 27 -=== **Project Aim** === 28 - 29 -The project aims to develop a **tridimensional diagnostic framework** with an **AI-powered annotation system**, integrating **etiology, molecular biomarkers, and neuroanatomoclinical correlations** for **precise, standardized, and scalable CNS disease diagnostics**. 30 - 31 31 The //Tridimensional Diagnostic Framework// redefines CNS diseases can be classified and diagnosed by focusing on: 32 32 33 33 * **Axis 1**: Etiology (genetic or other causes of diseases). ... ... @@ -40,16 +40,6 @@ 40 40 * Integration of incomplete datasets using AI-driven probabilistic modeling. 41 41 * Stratification of patients for personalized treatment. 42 42 43 -== **The Role of AI-Powered Annotation** == 44 - 45 -To enhance **standardization, interpretability, and clinical application**, the framework integrates **an AI-powered annotation system**, which: 46 - 47 -* **Assigns structured metadata tags** to diagnostic features. 48 -* **Provides real-time contextual explanations** for AI-based classifications. 49 -* **Tracks longitudinal disease progression** using timestamped AI annotations. 50 -* **Improves AI model transparency** through interpretability tools (e.g., SHAP analysis). 51 -* **Facilitates decision-making for clinicians** by linking annotations to standardized biomedical ontologies (SNOMED, HPO). 52 - 53 53 == **The case of neurodegenerative diseases** == 54 54 55 55 There have been described these 3 diagnostic axes: ... ... @@ -85,6 +85,10 @@ 85 85 * **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials. 86 86 * **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking. 87 87 67 +== Who has access? == 68 + 69 +We welcome contributions from the global community. Let’s build the future of neurological diagnostics together! 70 + 88 88 == How to Contribute == 89 89 90 90 * Access the `/docs` folder for guidelines. ... ... @@ -96,17 +96,11 @@ 96 96 * Develop interpretable AI models for diagnosis and progression tracking. 97 97 * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources. 98 98 * Foster collaboration among neuroscientists, AI researchers, and clinicians. 99 - 100 -== Who has access? == 101 - 102 -We welcome contributions from the global community. Let’s build the future of neurological diagnostics together! 103 103 ))) 104 104 105 105 106 106 107 107 108 - 109 - 110 110 (% class="col-xs-12 col-sm-4" %) 111 111 ((( 112 112 {{box title="**Contents**"}}