Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
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edited by manuelmenendez
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edited by manuelmenendez
on 2025/01/29 18:48
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5 -= Neurodiagnoses =
5 += //A new tridimensional diagnostic framework for CNS diseases// =
6 6  
7 -This project is focused on developing a novel nosological and diagnostic framework for neurological diseases. Using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies, we aim to create a structured, interpretable, and scalable diagnostic tool.
7 +This project is focused on developing a novel nosological and diagnostic framework for CNS diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 +We aim to create a structured, interpretable, and scalable diagnostic tool.
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10 10  
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15 -= What can I find here? =
16 += What is this about and what can I find here? =
16 16  
17 -* `/docs`: Documentation and contribution guidelines.
18 -* `/code`: Machine learning pipelines and scripts.
19 -* `/data`: Sample datasets for testing. - `/outputs`: Generated models, visualizations, and reports.
18 += **Overview** =
20 20  
21 -= Who has access? =
20 +The //Tridimensional Diagnostic Framework// redefines CNS diseases can be classified and diagnosed by focusing on:
22 22  
22 +* **Axis 1**: Etiology (genetic or other causes of diseases).
23 +* **Axis 2**: Molecular Markers (biomarkers).
24 +* **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 +
26 +This methodology enables:
27 +
28 +* Greater precision in diagnosis.
29 +* Integration of incomplete datasets using AI-driven probabilistic modeling.
30 +* Stratification of patients for personalized treatment.
31 +
32 +== **The case of neurodegenerative diseases** ==
33 +
34 +There have been described these 3 diagnostic axes:
35 +
36 +[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
37 +
38 +* (((
39 +**Axis 1: Etiology**
40 +
41 +* //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers.
42 +* //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression.
43 +* //Tests//: Genetic testing, lifestyle, and cardiovascular screening.
44 +)))
45 +* (((
46 +**Axis 2: Molecular Markers**
47 +
48 +* //Description//: Analyzes primary (amyloid-beta, tau) and secondary biomarkers (NFL, GFAP) for tracking disease progression.
49 +* //Examples//: CSF amyloid-beta concentrations to confirm Alzheimer’s pathology.
50 +* //Tests//: Blood/CSF biomarkers, PET imaging (Tau-PET, Amyloid-PET).
51 +)))
52 +* (((
53 +**Axis 3: Neuroanatomoclinical**
54 +
55 +* //Description//: Links clinical symptoms to neuroanatomical changes, such as atrophy or functional impairments.
56 +* //Examples//: Hippocampal atrophy correlating with memory deficits.
57 +* //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
58 +)))
59 +
60 +== **Applications** ==
61 +
62 +This system enhances:
63 +
64 +* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
65 +* **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
66 +
67 +== Who has access? ==
68 +
23 23  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
70 +
71 +== How to Contribute ==
72 +
73 +* Access the `/docs` folder for guidelines.
74 +* Use `/code` for the latest AI pipelines.
75 +* Share feedback and ideas in the wiki discussion pages.
76 +
77 +== Key Objectives ==
78 +
79 +* Develop interpretable AI models for diagnosis and progression tracking.
80 +* Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
81 +* Foster collaboration among neuroscientists, AI researchers, and clinicians.
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26 26  
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86 +
87 +
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29 29  {{box title="**Contents**"}}
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30 30  {{toc/}}
31 31  {{/box}}
32 32  
33 -
94 +== Main contents ==
95 +
96 +* `/docs`: Documentation and contribution guidelines.
97 +* `/code`: Machine learning pipelines and scripts.
98 +* `/data`: Sample datasets for testing.
99 +* `/outputs`: Generated models, visualizations, and reports.
100 +* [[Methodology>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Methodology/]]
101 +* [[Results>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Results/]]
102 +* [[to-do-list>>to-do-list]]
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