Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
From version 4.3
edited by manuelmenendez
on 2025/01/27 22:57
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To version 14.1
edited by manuelmenendez
on 2025/01/27 23:58
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5 -= Neurodiagnoses =
5 += //A new tridimensional diagnostic framework for CNS conditions// =
6 6  
7 -This project is focused on developing a novel nosological and diagnostic framework for neurological diseases. Using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies, we aim to create a structured, interpretable, and scalable diagnostic tool.
7 +This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 +We aim to create a structured, interpretable, and scalable diagnostic tool.
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10 10  
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15 -= What can I find here? =
16 += What is this about and what can I find here? =
16 16  
17 -* `/docs`: Documentation and contribution guidelines.
18 -* `/code`: Machine learning pipelines and scripts.
19 -* `/data`: Sample datasets for testing. - `/outputs`: Generated models, visualizations, and reports.
18 +== **Overview** ==
20 20  
21 -= Who has access? =
20 +The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
22 22  
22 +* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
23 +* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
24 +* **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 +
26 +[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
27 +
28 +This methodology enables:
29 +
30 +* Greater precision in diagnosis.
31 +* Integration of incomplete datasets using AI-driven probabilistic modeling.
32 +* Stratification of patients for personalized treatment.
33 +
34 +== **Diagnostic Axes** ==
35 +
36 +* (((
37 +**Axis 1: Etiology**
38 +
39 +* //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers.
40 +* //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression.
41 +* //Tests//: Genetic testing, lifestyle and cardiovascular screening.
42 +)))
43 +* (((
44 +**Axis 2: Molecular Markers**
45 +
46 +* //Description//: Analyzes primary (amyloid-beta, tau) and secondary biomarkers (NFL, GFAP) for tracking disease progression.
47 +* //Examples//: CSF amyloid-beta concentrations to confirm Alzheimer’s pathology.
48 +* //Tests//: Blood/CSF biomarkers, PET imaging (Tau-PET, Amyloid-PET).
49 +)))
50 +* (((
51 +**Axis 3: Neuroanatomoclinical**
52 +
53 +* //Description//: Links clinical symptoms to neuroanatomical changes, such as atrophy or functional impairments.
54 +* //Examples//: Hippocampal atrophy correlating with memory deficits.
55 +* //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
56 +)))
57 +
58 +== **Applications** ==
59 +
60 +This system enhances:
61 +
62 +* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
63 +* **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
64 +
65 +== Who has access? ==
66 +
23 23  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
68 +
69 +== How to Contribute ==
70 +
71 +* Access the `/docs` folder for guidelines.
72 +* Use `/code` for the latest AI pipelines.
73 +* Share feedback and ideas in the wiki discussion pages.
74 +
75 +== Key Objectives ==
76 +
77 +* Develop interpretable AI models for diagnosis and progression tracking.
78 +* Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
79 +* Foster collaboration among neuroscientists, AI researchers, and clinicians.
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25 25  
26 26  
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30 30  {{toc/}}
31 31  {{/box}}
32 32  
33 -
89 +== Main contents ==
90 +
91 +* `/docs`: Documentation and contribution guidelines.
92 +* `/code`: Machine learning pipelines and scripts.
93 +* `/data`: Sample datasets for testing.
94 +* `/outputs`: Generated models, visualizations, and reports.
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tridimensional.png
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