Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
From version 4.5
edited by manuelmenendez
on 2025/01/27 23:00
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To version 20.1
edited by manuelmenendez
on 2025/01/28 00:03
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5 -= Neurodiagnoses =
5 += //A new tridimensional diagnostic framework for neurodegenerative diseases// =
6 6  
7 -This project is focused on developing a novel nosological and diagnostic framework for neurological diseases. Using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies, we aim to create a structured, interpretable, and scalable diagnostic tool.
7 +This project is focused on developing a novel nosological and diagnostic framework for neurodegenerative diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 +We aim to create a structured, interpretable, and scalable diagnostic tool.
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10 10  
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15 -= What can I find here? =
16 += What is this about and what can I find here? =
16 16  
17 -* `/docs`: Documentation and contribution guidelines.
18 -* `/code`: Machine learning pipelines and scripts.
19 -* `/data`: Sample datasets for testing. - `/outputs`: Generated models, visualizations, and reports.
18 +== **Overview** ==
20 20  
21 -= Who has access? =
20 +The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDD) are classified by focusing on:
22 22  
22 +* **Axis 1**: Etiology (genetic or other causes of diseases).
23 +* **Axis 2**: Molecular Markers (biomarkers).
24 +* **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 +
26 +
27 +[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
28 +
29 +
30 +This methodology enables:
31 +
32 +* Greater precision in diagnosis.
33 +* Integration of incomplete datasets using AI-driven probabilistic modeling.
34 +* Stratification of patients for personalized treatment.
35 +
36 +== **Diagnostic Axes** ==
37 +
38 +* (((
39 +**Axis 1: Etiology**
40 +
41 +* //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers.
42 +* //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression.
43 +* //Tests//: Genetic testing, lifestyle and cardiovascular screening.
44 +)))
45 +* (((
46 +**Axis 2: Molecular Markers**
47 +
48 +* //Description//: Analyzes primary (amyloid-beta, tau) and secondary biomarkers (NFL, GFAP) for tracking disease progression.
49 +* //Examples//: CSF amyloid-beta concentrations to confirm Alzheimer’s pathology.
50 +* //Tests//: Blood/CSF biomarkers, PET imaging (Tau-PET, Amyloid-PET).
51 +)))
52 +* (((
53 +**Axis 3: Neuroanatomoclinical**
54 +
55 +* //Description//: Links clinical symptoms to neuroanatomical changes, such as atrophy or functional impairments.
56 +* //Examples//: Hippocampal atrophy correlating with memory deficits.
57 +* //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
58 +)))
59 +
60 +== **Applications** ==
61 +
62 +This system enhances:
63 +
64 +* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
65 +* **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
66 +
67 +== Who has access? ==
68 +
23 23  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
24 24  
25 -== How to Contribute: ==
71 +== How to Contribute ==
26 26  
27 27  * Access the `/docs` folder for guidelines.
28 28  * Use `/code` for the latest AI pipelines.
29 29  * Share feedback and ideas in the wiki discussion pages.
76 +
77 +== Key Objectives ==
78 +
79 +* Develop interpretable AI models for diagnosis and progression tracking.
80 +* Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
81 +* Foster collaboration among neuroscientists, AI researchers, and clinicians.
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31 31  
32 32  
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36 36  {{toc/}}
37 37  {{/box}}
38 38  
39 -== Key Objectives: ==
91 +== Main contents ==
40 40  
41 -* Develop interpretable AI models for diagnosis and progression tracking.
42 -* Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
43 -* Foster collaboration among neuroscientists, AI researchers, and clinicians.
44 -
93 +* `/docs`: Documentation and contribution guidelines.
94 +* `/code`: Machine learning pipelines and scripts.
95 +* `/data`: Sample datasets for testing.
96 +* `/outputs`: Generated models, visualizations, and reports.
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46 46  )))
tridimensional.png
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