Changes for page Neurodiagnoses
Last modified by manuelmenendez on 2025/03/03 22:46
From version 4.5
edited by manuelmenendez
on 2025/01/27 23:00
on 2025/01/27 23:00
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To version 23.1
edited by manuelmenendez
on 2025/01/29 18:46
on 2025/01/29 18:46
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... ... @@ -2,9 +2,10 @@ 2 2 ((( 3 3 (% class="container" %) 4 4 ((( 5 -= Neurodiagnoses =5 += //A new tridimensional diagnostic framework for CNS diseases// = 6 6 7 -This project is focused on developing a novel nosological and diagnostic framework for neurological diseases. Using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies, we aim to create a structured, interpretable, and scalable diagnostic tool. 7 +This project is focused on developing a novel nosological and diagnostic framework for CNS diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies. 8 +We aim to create a structured, interpretable, and scalable diagnostic tool. 8 8 ))) 9 9 ))) 10 10 ... ... @@ -12,21 +12,73 @@ 12 12 ((( 13 13 (% class="col-xs-12 col-sm-8" %) 14 14 ((( 15 -= What can I find here? = 16 += What is this about and what can I find here? = 16 16 17 -* `/docs`: Documentation and contribution guidelines. 18 -* `/code`: Machine learning pipelines and scripts. 19 -* `/data`: Sample datasets for testing. - `/outputs`: Generated models, visualizations, and reports. 18 +== **Overview** == 20 20 21 - = Whohas access?=20 +The //Tridimensional Diagnostic Framework// redefines CNS diseases can be classified and diagnosed by focusing on: 22 22 22 +* **Axis 1**: Etiology (genetic or other causes of diseases). 23 +* **Axis 2**: Molecular Markers (biomarkers). 24 +* **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system). 25 + 26 +[[For instance, neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]] 27 + 28 + 29 +This methodology enables: 30 + 31 +* Greater precision in diagnosis. 32 +* Integration of incomplete datasets using AI-driven probabilistic modeling. 33 +* Stratification of patients for personalized treatment. 34 + 35 +== **The case of neurodegenerative diseases** == 36 + 37 +There have been described these 3 diagnostic axes: 38 + 39 +* ((( 40 +**Axis 1: Etiology** 41 + 42 +* //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers. 43 +* //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression. 44 +* //Tests//: Genetic testing, lifestyle, and cardiovascular screening. 45 +))) 46 +* ((( 47 +**Axis 2: Molecular Markers** 48 + 49 +* //Description//: Analyzes primary (amyloid-beta, tau) and secondary biomarkers (NFL, GFAP) for tracking disease progression. 50 +* //Examples//: CSF amyloid-beta concentrations to confirm Alzheimer’s pathology. 51 +* //Tests//: Blood/CSF biomarkers, PET imaging (Tau-PET, Amyloid-PET). 52 +))) 53 +* ((( 54 +**Axis 3: Neuroanatomoclinical** 55 + 56 +* //Description//: Links clinical symptoms to neuroanatomical changes, such as atrophy or functional impairments. 57 +* //Examples//: Hippocampal atrophy correlating with memory deficits. 58 +* //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations. 59 +))) 60 + 61 +== **Applications** == 62 + 63 +This system enhances: 64 + 65 +* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials. 66 +* **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking. 67 + 68 +== Who has access? == 69 + 23 23 We welcome contributions from the global community. Let’s build the future of neurological diagnostics together! 24 24 25 -== How to Contribute :==72 +== How to Contribute == 26 26 27 27 * Access the `/docs` folder for guidelines. 28 28 * Use `/code` for the latest AI pipelines. 29 29 * Share feedback and ideas in the wiki discussion pages. 77 + 78 +== Key Objectives == 79 + 80 +* Develop interpretable AI models for diagnosis and progression tracking. 81 +* Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources. 82 +* Foster collaboration among neuroscientists, AI researchers, and clinicians. 30 30 ))) 31 31 32 32 ... ... @@ -36,11 +36,14 @@ 36 36 {{toc/}} 37 37 {{/box}} 38 38 39 -== KeyObjectives:==92 +== Main contents == 40 40 41 -* Develop interpretable AI models for diagnosis and progression tracking. 42 -* Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources. 43 -* Foster collaboration among neuroscientists, AI researchers, and clinicians. 44 - 94 +* `/docs`: Documentation and contribution guidelines. 95 +* `/code`: Machine learning pipelines and scripts. 96 +* `/data`: Sample datasets for testing. 97 +* `/outputs`: Generated models, visualizations, and reports. 98 +* [[Methodology>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Methodology/]] 99 +* [[Results>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Results/]] 100 +* [[to-do-list>>to-do-list]] 45 45 ))) 46 46 )))
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