Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
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edited by manuelmenendez
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To version 12.1
edited by manuelmenendez
on 2025/01/27 23:54
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5 -= Neurodiagnoses =
5 += //A new tridimensional diagnostic framework for CNS conditions// =
6 6  
7 -This project is focused on developing a novel nosological and diagnostic framework for neurological diseases. Using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies, we aim to create a structured, interpretable, and scalable diagnostic tool.
7 +This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 +We aim to create a structured, interpretable, and scalable diagnostic tool.
8 8  )))
9 9  )))
10 10  
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15 -= What can I find here? =
16 += What is this about and what can I find here? =
16 16  
18 +== **Overview** ==
19 +
20 +The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
21 +
22 +* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
23 +* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
24 +* **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 +
26 +This methodology enables:
27 +
28 +* Greater precision in diagnosis.
29 +* Integration of incomplete datasets using AI-driven probabilistic modeling.
30 +* Stratification of patients for personalized treatment.
31 +
32 +== **Diagnostic Axes** ==
33 +
34 +* (((
35 +**Axis 1: Etiology**
36 +
37 +* //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers.
38 +* //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression.
39 +* //Tests//: Genetic testing, lifestyle and cardiovascular screening.
40 +)))
41 +* (((
42 +**Axis 2: Molecular Markers**
43 +
44 +* //Description//: Analyzes primary (amyloid-beta, tau) and secondary biomarkers (NFL, GFAP) for tracking disease progression.
45 +* //Examples//: CSF amyloid-beta concentrations to confirm Alzheimer’s pathology.
46 +* //Tests//: Blood/CSF biomarkers, PET imaging (Tau-PET, Amyloid-PET).
47 +)))
48 +* (((
49 +**Axis 3: Neuroanatomoclinical**
50 +
51 +* //Description//: Links clinical symptoms to neuroanatomical changes, such as atrophy or functional impairments.
52 +* //Examples//: Hippocampal atrophy correlating with memory deficits.
53 +* //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
54 +)))
55 +
56 +== **Applications** ==
57 +
58 +This system enhances:
59 +
60 +* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
61 +* **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
62 +
17 17  == Who has access? ==
18 18  
19 19  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
20 20  
21 -== How to Contribute: ==
67 +== How to Contribute ==
22 22  
23 23  * Access the `/docs` folder for guidelines.
24 24  * Use `/code` for the latest AI pipelines.
25 25  * Share feedback and ideas in the wiki discussion pages.
26 26  
27 -== Key Objectives: ==
73 +== Key Objectives ==
28 28  
29 29  * Develop interpretable AI models for diagnosis and progression tracking.
30 30  * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
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38 38  {{toc/}}
39 39  {{/box}}
40 40  
41 -== Main contents: ==
87 +== Main contents ==
42 42  
43 43  * `/docs`: Documentation and contribution guidelines.
44 44  * `/code`: Machine learning pipelines and scripts.
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