Changes for page Neurodiagnoses
Last modified by manuelmenendez on 2025/03/03 22:46
From version 5.1
edited by manuelmenendez
on 2025/01/27 23:04
on 2025/01/27 23:04
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To version 16.1
edited by manuelmenendez
on 2025/01/28 00:00
on 2025/01/28 00:00
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... ... @@ -2,9 +2,10 @@ 2 2 ((( 3 3 (% class="container" %) 4 4 ((( 5 -= Neurodiagnoses =5 += //A new tridimensional diagnostic framework for CNS conditions// = 6 6 7 -This project is focused on developing a novel nosological and diagnostic framework for neurological diseases. Using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies, we aim to create a structured, interpretable, and scalable diagnostic tool. 7 +This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies. 8 +We aim to create a structured, interpretable, and scalable diagnostic tool. 8 8 ))) 9 9 ))) 10 10 ... ... @@ -12,19 +12,67 @@ 12 12 ((( 13 13 (% class="col-xs-12 col-sm-8" %) 14 14 ((( 15 -= What can I find here? = 16 += What is this about and what can I find here? = 16 16 18 +== **Overview** == 19 + 20 +The //Tridimensional Diagnostic Framework// redefines how CNS conditions are classified by focusing on: 21 + 22 +* **Axis 1**: Etiology (genetic or other causes of diseases). 23 +* **Axis 2**: Molecular Markers (biomarkers). 24 +* **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system). 25 + 26 +[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]] 27 + 28 + 29 +This methodology enables: 30 + 31 +* Greater precision in diagnosis. 32 +* Integration of incomplete datasets using AI-driven probabilistic modeling. 33 +* Stratification of patients for personalized treatment. 34 + 35 +== **Diagnostic Axes** == 36 + 37 +* ((( 38 +**Axis 1: Etiology** 39 + 40 +* //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers. 41 +* //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression. 42 +* //Tests//: Genetic testing, lifestyle and cardiovascular screening. 43 +))) 44 +* ((( 45 +**Axis 2: Molecular Markers** 46 + 47 +* //Description//: Analyzes primary (amyloid-beta, tau) and secondary biomarkers (NFL, GFAP) for tracking disease progression. 48 +* //Examples//: CSF amyloid-beta concentrations to confirm Alzheimer’s pathology. 49 +* //Tests//: Blood/CSF biomarkers, PET imaging (Tau-PET, Amyloid-PET). 50 +))) 51 +* ((( 52 +**Axis 3: Neuroanatomoclinical** 53 + 54 +* //Description//: Links clinical symptoms to neuroanatomical changes, such as atrophy or functional impairments. 55 +* //Examples//: Hippocampal atrophy correlating with memory deficits. 56 +* //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations. 57 +))) 58 + 59 +== **Applications** == 60 + 61 +This system enhances: 62 + 63 +* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials. 64 +* **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking. 65 + 17 17 == Who has access? == 18 18 19 19 We welcome contributions from the global community. Let’s build the future of neurological diagnostics together! 20 20 21 -== How to Contribute :==70 +== How to Contribute == 22 22 23 23 * Access the `/docs` folder for guidelines. 24 24 * Use `/code` for the latest AI pipelines. 25 25 * Share feedback and ideas in the wiki discussion pages. 26 26 27 -== Key Objectives :==76 +== Key Objectives == 28 28 29 29 * Develop interpretable AI models for diagnosis and progression tracking. 30 30 * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources. ... ... @@ -38,7 +38,7 @@ 38 38 {{toc/}} 39 39 {{/box}} 40 40 41 -== Main contents :==90 +== Main contents == 42 42 43 43 * `/docs`: Documentation and contribution guidelines. 44 44 * `/code`: Machine learning pipelines and scripts.
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