Changes for page Neurodiagnoses
Last modified by manuelmenendez on 2025/03/03 22:46
From version 6.1
edited by manuelmenendez
on 2025/01/27 23:21
on 2025/01/27 23:21
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To version 15.1
edited by manuelmenendez
on 2025/01/27 23:58
on 2025/01/27 23:58
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... ... @@ -2,8 +2,7 @@ 2 2 ((( 3 3 (% class="container" %) 4 4 ((( 5 -= **Neurodiagnoses** 6 -//A new tridimensional diagnostic framework for CNS conditions// = 5 += //A new tridimensional diagnostic framework for CNS conditions// = 7 7 8 8 This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies. 9 9 We aim to create a structured, interpretable, and scalable diagnostic tool. ... ... @@ -16,7 +16,7 @@ 16 16 ((( 17 17 = What is this about and what can I find here? = 18 18 19 -== ==**Overview** ====18 +== **Overview** == 20 20 21 21 The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on: 22 22 ... ... @@ -24,6 +24,9 @@ 24 24 * **Axis 2**: Molecular Markers (biomarkers and proteinopathies). 25 25 * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system). 26 26 26 +[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]] 27 + 28 + 27 27 This methodology enables: 28 28 29 29 * Greater precision in diagnosis. ... ... @@ -30,7 +30,7 @@ 30 30 * Integration of incomplete datasets using AI-driven probabilistic modeling. 31 31 * Stratification of patients for personalized treatment. 32 32 33 -== ==**Diagnostic Axes** ====35 +== **Diagnostic Axes** == 34 34 35 35 * ((( 36 36 **Axis 1: Etiology** ... ... @@ -54,28 +54,11 @@ 54 54 * //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations. 55 55 ))) 56 56 57 -== ==**Case Studies** ====59 +== **Applications** == 58 58 59 -1. ((( 60 -**Sporadic Alzheimer’s Disease**: 61 - 62 -* Axis 1: Sporadic (ApoE4, poor sleep habits). 63 -* Axis 2: Amyloid-beta plaques, elevated NFL. 64 -* Axis 3: Right hippocampus atrophy (visual memory loss). 65 -))) 66 -1. ((( 67 -**Genetic Parkinson’s Disease**: 68 - 69 -* Axis 1: Genetic (LRRK2 mutation). 70 -* Axis 2: Alpha-synuclein aggregation. 71 -* Axis 3: Substantia nigra degeneration (motor dysfunction). 72 -))) 73 - 74 -==== **Applications** ==== 75 - 76 76 This system enhances: 77 77 78 -* **Research**: By stratifying patients, itreduces cohort heterogeneity in clinical trials.63 +* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials. 79 79 * **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking. 80 80 81 81 == Who has access? == ... ... @@ -82,13 +82,13 @@ 82 82 83 83 We welcome contributions from the global community. Let’s build the future of neurological diagnostics together! 84 84 85 -== How to Contribute :==70 +== How to Contribute == 86 86 87 87 * Access the `/docs` folder for guidelines. 88 88 * Use `/code` for the latest AI pipelines. 89 89 * Share feedback and ideas in the wiki discussion pages. 90 90 91 -== Key Objectives :==76 +== Key Objectives == 92 92 93 93 * Develop interpretable AI models for diagnosis and progression tracking. 94 94 * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources. ... ... @@ -102,7 +102,7 @@ 102 102 {{toc/}} 103 103 {{/box}} 104 104 105 -== Main contents :==90 +== Main contents == 106 106 107 107 * `/docs`: Documentation and contribution guidelines. 108 108 * `/code`: Machine learning pipelines and scripts.
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