Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
From version 6.1
edited by manuelmenendez
on 2025/01/27 23:21
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To version 17.1
edited by manuelmenendez
on 2025/01/28 00:00
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2 2  (((
3 3  (% class="container" %)
4 4  (((
5 -= **Neurodiagnoses**
6 -//A new tridimensional diagnostic framework for CNS conditions// =
5 += //A new tridimensional diagnostic framework for neurodegenerative diseases// =
7 7  
8 8  This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
9 9  We aim to create a structured, interpretable, and scalable diagnostic tool.
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16 16  (((
17 17  = What is this about and what can I find here? =
18 18  
19 -==== **Overview** ====
18 +== **Overview** ==
20 20  
21 -The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
20 +The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDD) are classified by focusing on:
22 22  
23 -* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
24 -* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
22 +* **Axis 1**: Etiology (genetic or other causes of diseases).
23 +* **Axis 2**: Molecular Markers (biomarkers).
25 25  * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
26 26  
26 +[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
27 +
28 +
27 27  This methodology enables:
28 28  
29 29  * Greater precision in diagnosis.
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30 30  * Integration of incomplete datasets using AI-driven probabilistic modeling.
31 31  * Stratification of patients for personalized treatment.
32 32  
33 -==== **Diagnostic Axes** ====
35 +== **Diagnostic Axes** ==
34 34  
35 35  * (((
36 36  **Axis 1: Etiology**
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54 54  * //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
55 55  )))
56 56  
57 -==== **Case Studies** ====
59 +== **Applications** ==
58 58  
59 -1. (((
60 -**Sporadic Alzheimer’s Disease**:
61 -
62 -* Axis 1: Sporadic (ApoE4, poor sleep habits).
63 -* Axis 2: Amyloid-beta plaques, elevated NFL.
64 -* Axis 3: Right hippocampus atrophy (visual memory loss).
65 -)))
66 -1. (((
67 -**Genetic Parkinson’s Disease**:
68 -
69 -* Axis 1: Genetic (LRRK2 mutation).
70 -* Axis 2: Alpha-synuclein aggregation.
71 -* Axis 3: Substantia nigra degeneration (motor dysfunction).
72 -)))
73 -
74 -==== **Applications** ====
75 -
76 76  This system enhances:
77 77  
78 -* **Research**: By stratifying patients, it reduces cohort heterogeneity in clinical trials.
63 +* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
79 79  * **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
80 80  
81 81  == Who has access? ==
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82 82  
83 83  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
84 84  
85 -== How to Contribute: ==
70 +== How to Contribute ==
86 86  
87 87  * Access the `/docs` folder for guidelines.
88 88  * Use `/code` for the latest AI pipelines.
89 89  * Share feedback and ideas in the wiki discussion pages.
90 90  
91 -== Key Objectives: ==
76 +== Key Objectives ==
92 92  
93 93  * Develop interpretable AI models for diagnosis and progression tracking.
94 94  * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
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102 102  {{toc/}}
103 103  {{/box}}
104 104  
105 -== Main contents: ==
90 +== Main contents ==
106 106  
107 107  * `/docs`: Documentation and contribution guidelines.
108 108  * `/code`: Machine learning pipelines and scripts.
tridimensional.png
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