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2	2	(((
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4	4	(((
5		-= **Neurodiagnoses**
6		-//A new tridimensional diagnostic framework for CNS conditions// =
	5	+= //A new tridimensional diagnostic framework for CNS diseases// =
7	7
8		-This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
	7	+This project is focused on developing a novel nosological and diagnostic framework for CNS diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
9	9	We aim to create a structured, interpretable, and scalable diagnostic tool.
10	10	)))
11	11	)))
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16	16	(((
17	17	= What is this about and what can I find here? =
18	18
19		-==== **Overview** ====
	18	+= **Overview** =
20	20
21		-The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
	20	+The //Tridimensional Diagnostic Framework// redefines CNS diseases can be classified and diagnosed by focusing on:
22	22
23		-* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
24		-* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
	22	+* **Axis 1**: Etiology (genetic or other causes of diseases).
	23	+* **Axis 2**: Molecular Markers (biomarkers).
25	25	* **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
26	26
27	27	This methodology enables:
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30	30	* Integration of incomplete datasets using AI-driven probabilistic modeling.
31	31	* Stratification of patients for personalized treatment.
32	32
33		-==== **Diagnostic Axes** ====
	32	+== **The case of neurodegenerative diseases** ==
34	34
	34	+There have been described these 3 diagnostic axes:
	35	+
	36	+[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
	37	+
35	35	* (((
36	36	**Axis 1: Etiology**
37	37
38	38	* //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers.
39	39	* //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression.
40		-* //Tests//: Genetic testing, lifestyle and cardiovascular screening.
	43	+* //Tests//: Genetic testing, lifestyle, and cardiovascular screening.
41	41	)))
42	42	* (((
43	43	**Axis 2: Molecular Markers**
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54	54	* //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
55	55	)))
56	56
57		-==== **Case Studies** ====
	60	+== **Applications** ==
58	58
59		-1. (((
60		-**Sporadic Alzheimer’s Disease**:
61		-
62		-* Axis 1: Sporadic (ApoE4, poor sleep habits).
63		-* Axis 2: Amyloid-beta plaques, elevated NFL.
64		-* Axis 3: Right hippocampus atrophy (visual memory loss).
65		-)))
66		-1. (((
67		-**Genetic Parkinson’s Disease**:
68		-
69		-* Axis 1: Genetic (LRRK2 mutation).
70		-* Axis 2: Alpha-synuclein aggregation.
71		-* Axis 3: Substantia nigra degeneration (motor dysfunction).
72		-)))
73		-
74		-==== **Applications** ====
75		-
76	76	This system enhances:
77	77
78		-* **Research**: By stratifying patients, it reduces cohort heterogeneity in clinical trials.
	64	+* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
79	79	* **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
80	80
81	81	== Who has access? ==
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82	82
83	83	We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
84	84
85		-== How to Contribute: ==
	71	+== How to Contribute ==
86	86
87	87	* Access the `/docs` folder for guidelines.
88	88	* Use `/code` for the latest AI pipelines.
89	89	* Share feedback and ideas in the wiki discussion pages.
90	90
91		-== Key Objectives: ==
	77	+== Key Objectives ==
92	92
93	93	* Develop interpretable AI models for diagnosis and progression tracking.
94	94	* Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
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96	96	)))
97	97
98	98
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	87	+
99	99	(% class="col-xs-12 col-sm-4" %)
100	100	(((
101	101	{{box title="**Contents**"}}
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102	102	{{toc/}}
103	103	{{/box}}
104	104
105		-== Main contents: ==
	94	+== Main contents ==
106	106
107	107	* `/docs`: Documentation and contribution guidelines.
108	108	* `/code`: Machine learning pipelines and scripts.
109	109	* `/data`: Sample datasets for testing.
110	110	* `/outputs`: Generated models, visualizations, and reports.
	100	+* [[Methodology>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Methodology/]]
	101	+* [[Results>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Results/]]
	102	+* [[to-do-list>>to-do-list]]
111	111	)))
112	112	)))

tridimensional.png

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