Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
From version 7.1
edited by manuelmenendez
on 2025/01/27 23:21
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To version 18.1
edited by manuelmenendez
on 2025/01/28 00:02
Change comment: There is no comment for this version

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2 2  (((
3 3  (% class="container" %)
4 4  (((
5 -= //A new tridimensional diagnostic framework for CNS conditions// =
5 += //A new tridimensional diagnostic framework for neurodegenerative diseases// =
6 6  
7 7  This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 8  We aim to create a structured, interpretable, and scalable diagnostic tool.
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15 15  (((
16 16  = What is this about and what can I find here? =
17 17  
18 -==== **Overview** ====
18 +== **Overview** ==
19 19  
20 -The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
20 +The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDD) are classified by focusing on:
21 21  
22 -* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
23 -* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
22 +* **Axis 1**: Etiology (genetic or other causes of diseases).
23 +* **Axis 2**: Molecular Markers (biomarkers).
24 24  * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 25  
26 +[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
27 +
28 +
26 26  This methodology enables:
27 27  
28 28  * Greater precision in diagnosis.
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29 29  * Integration of incomplete datasets using AI-driven probabilistic modeling.
30 30  * Stratification of patients for personalized treatment.
31 31  
32 -==== **Diagnostic Axes** ====
35 +== **Diagnostic Axes** ==
33 33  
34 34  * (((
35 35  **Axis 1: Etiology**
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53 53  * //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
54 54  )))
55 55  
56 -==== **Case Studies** ====
59 +== **Applications** ==
57 57  
58 -1. (((
59 -**Sporadic Alzheimer’s Disease**:
60 -
61 -* Axis 1: Sporadic (ApoE4, poor sleep habits).
62 -* Axis 2: Amyloid-beta plaques, elevated NFL.
63 -* Axis 3: Right hippocampus atrophy (visual memory loss).
64 -)))
65 -1. (((
66 -**Genetic Parkinson’s Disease**:
67 -
68 -* Axis 1: Genetic (LRRK2 mutation).
69 -* Axis 2: Alpha-synuclein aggregation.
70 -* Axis 3: Substantia nigra degeneration (motor dysfunction).
71 -)))
72 -
73 -==== **Applications** ====
74 -
75 75  This system enhances:
76 76  
77 -* **Research**: By stratifying patients, it reduces cohort heterogeneity in clinical trials.
63 +* **Research**: By stratifying patients, reduces cohort heterogeneity in clinical trials.
78 78  * **Clinical Practice**: Provides dynamic diagnostic annotations with timestamps for longitudinal tracking.
79 79  
80 80  == Who has access? ==
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81 81  
82 82  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
83 83  
84 -== How to Contribute: ==
70 +== How to Contribute ==
85 85  
86 86  * Access the `/docs` folder for guidelines.
87 87  * Use `/code` for the latest AI pipelines.
88 88  * Share feedback and ideas in the wiki discussion pages.
89 89  
90 -== Key Objectives: ==
76 +== Key Objectives ==
91 91  
92 92  * Develop interpretable AI models for diagnosis and progression tracking.
93 93  * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
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101 101  {{toc/}}
102 102  {{/box}}
103 103  
104 -== Main contents: ==
90 +== Main contents ==
105 105  
106 106  * `/docs`: Documentation and contribution guidelines.
107 107  * `/code`: Machine learning pipelines and scripts.
tridimensional.png
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