Changes for page Neurodiagnoses

Last modified by manuelmenendez on 2025/03/03 22:46
From version 8.1
edited by manuelmenendez
on 2025/01/27 23:22
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To version 26.1
edited by manuelmenendez
on 2025/01/29 18:48
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5 -= //A new tridimensional diagnostic framework for CNS conditions// =
5 += //A new tridimensional diagnostic framework for CNS diseases// =
6 6  
7 -This project is focused on developing a novel nosological and diagnostic framework for neurological diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
7 +This project is focused on developing a novel nosological and diagnostic framework for CNS diseases by using advanced AI techniques and integrating data from neuroimaging, biomarkers, and biomedical ontologies.
8 8  We aim to create a structured, interpretable, and scalable diagnostic tool.
9 9  )))
10 10  )))
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15 15  (((
16 16  = What is this about and what can I find here? =
17 17  
18 -==== **Overview** ====
18 +== **Overview** ==
19 19  
20 -The //Tridimensional Diagnostic Framework// redefines how neurodegenerative diseases (NDDs) are classified by focusing on:
20 +The //Tridimensional Diagnostic Framework// redefines CNS diseases can be classified and diagnosed by focusing on:
21 21  
22 -* **Axis 1**: Etiology (genetic/sporadic and environmental factors).
23 -* **Axis 2**: Molecular Markers (biomarkers and proteinopathies).
22 +* **Axis 1**: Etiology (genetic or other causes of diseases).
23 +* **Axis 2**: Molecular Markers (biomarkers).
24 24  * **Axis 3**: Neuroanatomoclinical correlations (linking clinical symptoms to structural changes in the nervous system).
25 25  
26 26  This methodology enables:
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29 29  * Integration of incomplete datasets using AI-driven probabilistic modeling.
30 30  * Stratification of patients for personalized treatment.
31 31  
32 -==== **Diagnostic Axes** ====
32 +== **The case of neurodegenerative diseases** ==
33 33  
34 +There have been described these 3 diagnostic axes:
35 +
36 +[[Neurodegenerative diseases can be studied and classified in a tridimensional scheme with three axes: anatomic–clinical, molecular, and etiologic. CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; PET, positron emission tomography.>>image:tridimensional.png||alt="tridimensional view of neurodegenerative diseases"]]
37 +
34 34  * (((
35 35  **Axis 1: Etiology**
36 36  
37 37  * //Description//: Focuses on genetic and sporadic causes, identifying risk factors and potential triggers.
38 38  * //Examples//: APOE ε4 as a genetic risk factor, or cardiovascular health affecting NDD progression.
39 -* //Tests//: Genetic testing, lifestyle and cardiovascular screening.
43 +* //Tests//: Genetic testing, lifestyle, and cardiovascular screening.
40 40  )))
41 41  * (((
42 42  **Axis 2: Molecular Markers**
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53 53  * //Tests//: MRI volumetrics, FDG-PET, neuropsychological evaluations.
54 54  )))
55 55  
56 -==== **Applications** ====
60 +== **Applications** ==
57 57  
58 58  This system enhances:
59 59  
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64 64  
65 65  We welcome contributions from the global community. Let’s build the future of neurological diagnostics together!
66 66  
67 -== How to Contribute: ==
71 +== How to Contribute ==
68 68  
69 69  * Access the `/docs` folder for guidelines.
70 70  * Use `/code` for the latest AI pipelines.
71 71  * Share feedback and ideas in the wiki discussion pages.
72 72  
73 -== Key Objectives: ==
77 +== Key Objectives ==
74 74  
75 75  * Develop interpretable AI models for diagnosis and progression tracking.
76 76  * Integrate data from Human Phenotype Ontology (HPO), Gene Ontology (GO), and other biomedical resources.
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78 78  )))
79 79  
80 80  
85 +
86 +
81 81  (% class="col-xs-12 col-sm-4" %)
82 82  (((
83 83  {{box title="**Contents**"}}
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84 84  {{toc/}}
85 85  {{/box}}
86 86  
87 -== Main contents: ==
93 +== Main contents ==
88 88  
89 89  * `/docs`: Documentation and contribution guidelines.
90 90  * `/code`: Machine learning pipelines and scripts.
91 91  * `/data`: Sample datasets for testing.
92 92  * `/outputs`: Generated models, visualizations, and reports.
99 +* [[Methodology>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Methodology/]]
100 +* [[Results>>url:https://wiki.ebrains.eu/bin/view/Collabs/neurodiagnoses/Results/]]
101 +* [[to-do-list>>to-do-list]]
93 93  )))
94 94  )))
tridimensional.png
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