Changes for page Methodology

Last modified by manuelmenendez on 2025/03/14 08:31
From version 22.1
edited by manuelmenendez
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To version 25.1
edited by manuelmenendez
on 2025/02/22 18:32
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Summary

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4 4  
5 5  Neuromarker extends the Common Alzheimer’s Disease Research Ontology (CADRO) into a comprehensive biomarker categorization framework applicable to all neurodegenerative diseases (NDDs). This ontology enables standardized classification, AI-based feature extraction, and seamless multimodal data integration.
6 6  
7 +**Recommended Software**
8 +
9 +There is a suite of software that can help implement the workflow needed in Neurodiagnoses. Find a list of recommendations [[here>>https://github.com/Fundacion-de-Neurociencias/neurodiagnoses/blob/main/recommended_software]].
10 +
7 7  **Core Biomarker Categories**
8 8  
9 9  Within the Neurodiagnoses AI framework, biomarkers are categorized as follows:
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11 11  |=**Category**|=**Description**
12 12  |**Molecular Biomarkers**|Omics-based markers (genomic, transcriptomic, proteomic, metabolomic, lipidomic)
13 13  |**Neuroimaging Biomarkers**|Structural (MRI, CT), Functional (fMRI, PET), Molecular Imaging (tau, amyloid, α-synuclein)
14 -|**Fluid Biomarkers**|CSF, plasma, blood-based markers for tau, amyloid, α-synuclein, TDP-43, GFAP, NfL
18 +|**Fluid Biomarkers**|CSF, plasma, blood-based markers for tau, amyloid, α-synuclein, TDP-43, GFAP, NfL, autoantiboides
15 15  |**Neurophysiological Biomarkers**|EEG, MEG, evoked potentials (ERP), sleep-related markers
16 16  |**Digital Biomarkers**|Gait analysis, cognitive/speech biomarkers, wearables data, EHR-based markers
17 17  |**Clinical Phenotypic Markers**|Standardized clinical scores (MMSE, MoCA, CDR, UPDRS, ALSFRS, UHDRS)
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103 103  
104 104  **Contact**: [[info@neurodiagnoses.com>>mailto:info@neurodiagnoses.com]]
105 105  
106 -
110 +**Final Notes**
111 +
112 +Neurodiagnoses AI is committed to advancing the integration of artificial intelligence in neurodiagnostic processes. By continuously expanding our data ecosystem and incorporating standardized biomarker classifications through the Neuromarker ontology, we aim to enhance cross-disease AI training and improve diagnostic accuracy across neurodegenerative disorders.
113 +
114 +We encourage researchers and institutions to contribute new datasets and methodologies to further enrich this collaborative platform. Your participation is vital in driving innovation and fostering a deeper understanding of complex neurological conditions.
115 +
116 +**For additional technical documentation and collaboration opportunities:**
117 +
118 +* **GitHub Repository:** [[Neurodiagnoses GitHub>>url:https://github.com/neurodiagnoses]]
119 +* **EBRAINS Collaboration Page:** [[EBRAINS Neurodiagnoses>>url:https://ebrains.eu/collabs/neurodiagnoses]]
120 +
121 +If you encounter any issues during data integration or have suggestions for improvement, please open a GitHub Issue or consult the EBRAINS Neurodiagnoses Forum. Together, we can advance the field of neurodiagnostics and contribute to better patient outcomes.