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Author

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1		-XWiki.bschaffha
	1	+XWiki.melissargos

Content

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43	43	**Prerequisite – Step 1**: Access to the MIP requires an EBRAINS user account, which needs to be permitted and authenticated. EBRAINS user accounts are available to users with a legitimate interest (mainly research and development) from Europe and beyond.
44	44
45	45	Request an EBRAINS user account: [[https:~~/~~/www.ebrains.eu/page/sign-up>>url:https://www.ebrains.eu/page/sign-up]]
46		-The EBRAINS user account allows users to directly access the Public MIP ([[https:~~/~~/mip.ebrains.eu/>>url:https://mip.ebrains.eu/]]) with no further accreditation being required.
	46	+The EBRAINS user account allows users to directly access the** Public MIP ([[https:~~/~~/mip.ebrains.eu/>>url:https://mip.ebrains.eu/]]**) with no further accreditation being required.
47	47
48		-**Access to a specific federation – Step 2:** EBRAINS authorised Users with an active EBRAINS account can request access to a specific federation by contacting [[support@ebrains.eu>>path:mailto:support@ebrains.eu]], who will forward the specific request to the MIP Management team. Users can also get in direct contact with the MIP team via the online form on the EBRAINS website: [[https:~~/~~/www.ebrains.eu/tools/medical-informatics-platform>>url:https://www.ebrains.eu/tools/medical-informatics-platform]]
	48	+**Access to a specific MIP Federation – Step 2:** EBRAINS authorised Users with an active EBRAINS account can request access to a specific MIP Federation by contacting [[support@ebrains.eu>>path:mailto:support@ebrains.eu]], who will forward the specific request to the MIP Management team. Users can also get in direct contact with the MIP team via the online form on the EBRAINS website: [[https:~~/~~/www.ebrains.eu/tools/medical-informatics-platform>>url:https://www.ebrains.eu/tools/medical-informatics-platform]]
49	49
50		-The Data Science Steering Committee (DSSC) of the specific federation will be involved in the accreditation process to receive access approvals.
	50	+The Data Science Steering Committee (DSSC) of the specific federation will be involved in the accreditation process to receive access approvals. The creation of a new MIP Federation projects can be initiated at any time.
51	51
52		-New federated projects can be initiated at any time. Users are required to accept the EBRAINS Terms and Policies [[https:~~/~~/www.ebrains.eu/page/terms-and-policies>>url:https://www.ebrains.eu/page/terms-and-policies]], to indicate acceptance and compliance with all applicable laws, regulations, rules, and approvals in the use and sharing of the data, including, but not limited to, the General Data Protection Regulation (GDPR).
	52	+Users are required to accept the EBRAINS Terms and Policies [[https:~~/~~/www.ebrains.eu/page/terms-and-policies>>url:https://www.ebrains.eu/page/terms-and-policies]], to indicate acceptance and compliance with all applicable laws, regulations, rules, and approvals in the use and sharing of the data, including, but not limited to, the General Data Protection Regulation (GDPR).
53	53
54		-Upon login to the MIP, users are mandated to accept the Terms of Use of the MIP. Accredited users access the MIP through a web-based interface, which will provide them with access to the respective federation on the MIP.
	54	+Upon login to the MIP, users are mandated to accept the Terms of Use of the MIP. Accredited users access the MIP through a web-based interface, which will provide them with direct access to the respective federation on the MIP.
55	55
56	56
57	57	== MIP Data Governance ==
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107	107	|(((
108	108	**Figure 3**// MIP Data Flow//
109	109
110		-//T(% class="small" %)his diagramme illustrates the MIP Data Flow, indicating processing steps prior to data upload and steps after data upload to the MIP.  EHR – electronic health record, MRI - magnetic resonance imaging, ETL - data integration (extract, transform, load), CDE – common data elements, ML – machine learning, GUI – graphical user interface, VM – virtual machine. Data pre-processing: extract data from EHR records and produce pseudonymised data in .csv format; optional Step1: extract brain volumes from MRI images and merge with data extracted from EHR records; Data Quality and Harmonisation: Prepare CDE: if CDE exists – Steps 2B, 4 and 5 are followed; if CDE needs to be prepared, first Steps 2A and 3A need to be performed, followed by Steps 2B, 4 and 5. Data Analysis and ML: anonymised dataset is uploaded either to the federated node in the institution or the dedicated VM on EBRAINS CSCS. Data Analysis can be performed via the Federation Service Layer and User Interface: use of predefined federated algorithms, aggregated results will be retrieved via the GUI.//
	110	+//T(% class="small" %)his diagram illustrates the MIP Data Flow, indicating processing steps prior to data upload and steps after data upload to the MIP.  EHR – electronic health record, MRI - magnetic resonance imaging, ETL - data integration (extract, transform, load), CDE – common data elements, ML – machine learning, GUI – graphical user interface, VM – virtual machine. Data pre-processing: extract data from EHR records and produce pseudonymised data in .csv format; optional Step1: extract brain volumes from MRI images and merge with data extracted from EHR records; Data Quality and Harmonisation: Prepare CDE: if CDE exists – Steps 2B, 4 and 5 are followed; if CDE needs to be prepared, first Steps 2A and 3A need to be performed, followed by Steps 2B, 4 and 5. Data Analysis and ML: anonymised dataset is uploaded either to the federated node in the institution or the dedicated VM on EBRAINS CSCS. Data Analysis can be performed via the Federation Service Layer and User Interface: use of predefined federated algorithms, aggregated results will be retrieved via the GUI.//
111	111	)))
112	112
113	113	== MIP GDPR compliance assessment ==
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164	164	* (% style="color:#c0392b" %)//DPIA * under preparation//
165	165	* Data Transfer agreement or Data Sharing Agreement
166	166	* Collaboration Agreement
167		-* Data Use agreement
	167	+* MIP User Charter
168	168	* MIP Installation Agreement
169	169	)))
170	170	)))