Changes for page 01. Introduction to neuronal simulation with PyNN
Last modified by adavison on 2021/08/03 17:48
Summary
-
Page properties (1 modified, 0 added, 0 removed)
Details
- Page properties
-
- Content
-
... ... @@ -19,8 +19,19 @@ 19 19 20 20 == Prerequisites == 21 21 22 -. 22 +To follow this tutorial, you need a basic knowledge of neuroscience (high-school level or greater). For example, you should know: 23 23 24 +* The brain is made up of electrically excitable cells called neurons, which have long, narrow extensions called dendrites and axons. 25 +* Neurons have a voltage difference across their cell membrane due to differences in the concentration of sodium, potassium, calcium, chloride and other ions between the inside and the outside of the cell. 26 +* The neuron cell membrane contains many proteins that can open or close to allow diffusion of different ions, or can actively transport ions across the membrane; this can cause rapid changes in the voltage difference. 27 +* In general neurons receive signals from other neurons in their dendrites, and generate electrical pulses (large, rapid changes in the membrane voltage lasting a few milliseconds or less) called action potentials that travel down their axons to other neurons. 28 +* The connections between neurons are called synapses, and the most common type of synapse is the chemical synapse, at which the arrival of an action potential triggers the release of a chemical, called a neurotransmitter, from one neuron into the space between two neurons; this chemical then diffuses across this space, and binds to proteins called receptors on the other neurons; this binding then leads to movements of ions across the cell membrane, and hence to changes in membrane voltage. 29 +* Most neurons have a threshold voltage above which they will generate an action potential; most of the time, the membrane potential is below this level. When the voltage moves closer to this threshold we speak of "exciting" or "depolarising" the neuron; when the voltage moves away from this threshold, we speak of "inhibiting" or "hyperpolarising" the neuron. 30 +* Some neurotransmitters cause depolarisation, others hyperpolarisation. 31 +* In general, each synapse releases only one type of neurotransmitter, so we speak of "excitatory" or "inhibitory" synapses, depending on the effect of the neurotransmitter they release. 32 +* In general, all the synapses of a given type of neuron release the same neurotransmitter, therefore we speak of "excitatory" or "inhibitory" neurons. 33 +* Nervous systems are very complex, and most of the statements above are approximations, simplifications, or "general rules" with many exceptions! 34 + 24 24 == Format == 25 25 26 26 .