Summary

• Page properties (1 modified, 0 added, 0 removed)

Details

Page properties

Content

...	...	@@ -31,7 +31,8 @@
31	31	(% class="wikigeneratedid" %)
32	32	The Showcase 1 aimed at investigations related to variability in neuroscience from two perspectives: (a) the interpersonal variability studied by the virtual ageing study, and (b) the variability across different cortical regions within an individual brain.
33	33
34		-== a. Interpersonal variability—virtual ageing ==
	34	+(% class="wikigeneratedid" %)
	35	+== (a) Interpersonal variability—virtual ageing ==
35	35
36	36	(% class="wikigeneratedid" %)
37	37	See the details of the first study in the following publication:
...	...	@@ -77,9 +77,10 @@
77	77
78	78	* [[virtual_ageing/notebooks/3_inference_with_SBI.ipynb>>https://lab.ch.ebrains.eu/user-redirect/lab/tree/shared/SGA3%20D1.2%20Showcase%201/virtual_ageing/notebooks/3_inference_with_SBI.ipynb]]
79	79
80		-== b. Regional variability ==
	81	+(% class="wikigeneratedid" %)
	82	+== (b) Regional variability ==
81	81
82		-Aims at demonstrating the construction of whole-brain network models of the brain's activity, accounting for differences in receptor densities across cortical regions.
	84	+Aims at demonstrating the construction of whole-brain network models of the brain's activity accounting for differences in receptor densities across cortical regions.
83	83
84	84	=== Loading the data from EBRAINS ===
85	85
...	...	@@ -87,9 +87,9 @@
87	87
88	88	1. Structural connectivity matrices,
89	89	1. GABAa and AMPA receptor densities for each brain region, and
90		-1. empirical resting-state fMRI data for fitting and validation of the simulations.
	92	+1. empirical resting-state fMRI data for fitting and validation of the simulations. The three datasets shall be characterised in the same parcellation.
91	91
92		-The three datasets shall be characterised in the same parcellation. Link to the notebook:
	94	+Link to the notebook:
93	93
94	94	* [[regional_variability/notebooks/1_load_data.ipynb>>https://lab.ch.ebrains.eu/hub/user-redirect/lab/tree/shared/SGA3%20D1.2%20Showcase%201/regional_variability/notebooks/1_load_data.ipynb]]
95	95
...	...	@@ -96,9 +96,9 @@
96	96	(% style="text-align:center" %)
97	97	[[image:download - 2022-02-10T130815.902.png||alt="region-wise gene expression heterogeneity"]]
98	98
99		-=== Fitting model parameters for models with regional bias ===
	101	+== Fitting model parameters for models with regional bias ==
100	100
101		-A series of simulations of the whole-brain network model are launched in the EBRAINS HPC facilities in order to identify the optimal model parameters leading to simulated resting-state brain activity that best resembles the empirically observed activity. In this branch of the showcase, brain regions are simulated using the mean-field AdEx population model; specifically modified to account for the regional densities of GABAa and AMPA neuroreceptors. See the details following document.
	103	+A series of simulations of the whole-brain network model are launched in the EBRAINS HPC facilities in order to identify the optimal model parameters leading to simulated resting-state brain activity that best resembles the empirically observed activity. In this branch of the showcase, brain regions are simulated using the Balanced Excitation-Inhibition model which allows to tune the E-I balance for every region individually, according to the empirically observed GABA and AMPA neuroreceptor densities.
102	102
103	103	Link to the notebook:
104	104