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... ... @@ -1,7 +1,11 @@ 1 - **HumanBrainProjectToolsDescription**1 +EBRAINS offers an extensive range of data and also provides compute resources (High-performance computing and Neuromorphic hardware). SLU can guide your journey on EBRAINS, show you how you find tools/data/related research projects appropriate for your research, and help you translate your work from the structured formalization process of science to technical requirements on EBRAINS. 2 2 3 - Onthisage youwillfindalistwithabriefdescription ofthe toolswe havefor theHBP toolsBook, if youhave asuggestionor detectanomissionpleasesendyourfeedbackto[[slu@ebrains.eu>>mailto:slu@ebrains.eu]].3 +EBRAINS support teams will help you connect to the community and give you tips for creating your simulations and models. If you are a neuroscientist, professor, or student, or are you interested in brain-related research, simulation, AI, robotics, and brain-inspired hardware check out what EBRAINS has for you. 4 4 5 +As a researcher, you might find yourself immersed in a continuous flow of information, data, environments, and platforms which offer different tools and aids to fulfill an investigation and publish your results. This new way to doing science helps us advance at a fast pace and reduces efforts on searching data and tests, also allows us to deploy state-of-the-art simulations that can improve the quality of our work, and increase the capacity of neuroscientists for multiscale neural activity modeling of the human brain network. 6 + 7 +On this page you will find a quick overview of the different tools and services available in EBRAINS. It will address, in an interactive way, how to use EBRAINS for specific use cases from the participants and focus on exploring all the potential that EBRAINS, as a digital research infrastructure, provides to its users. Researchers will have the opportunity to get creative and combine the different EBRAINS components to respond to existing questions and formulate new avenues based on collaboration, sharing, co-design, and innovation. 8 + 5 5 {{html}} 6 6 <html> 7 7 ... ... @@ -1309,7 +1309,7 @@ 1309 1309 1310 1310 <h2><a name="_Toc138932256"><span lang=en-DE>BioNAR</span></a></h2> 1311 1311 1312 -<p class=MsoNormal><span lang=en-DE>BioNAR combines a selection of 1316 +<p class=MsoNormal><span lang=en-DE>"BioNAR combines a selection of 1313 1313 existing R protocols for network analysis with newly designed original 1314 1314 methodological features to support step-by-step analysis of 1315 1315 biological/biomedical networks. BioNAR supports a pipeline approach where many ... ... @@ -1319,7 +1319,7 @@ 1319 1319 independent annotation enrichment</span><span lang=en-DE style='font-family: 1320 1320 "Times New Roman",serif'> </span><span lang=en-DE>predict a proteins influence 1321 1321 within and across multiple sub-complexes in the network and estimate the 1322 -co-occurrence or linkage between meta-data at the network level.</span></p> 1326 +co-occurrence or linkage between meta-data at the network level."</span></p> 1323 1323 1324 1324 <h2></h2> 1325 1325 ... ... @@ -1398,7 +1398,7 @@ 1398 1398 1399 1399 <h2><a name="_Toc138932263"><span lang=en-DE>BrainScaleS</span></a></h2> 1400 1400 1401 -<p class=MsoNormal><span lang=en-DE>Emulate spiking neural networks in 1405 +<p class=MsoNormal><span lang=en-DE>"Emulate spiking neural networks in 1402 1402 continuous time on the BrainScaleS analog neuromorphic computing system. Models 1403 1403 and experiments can be described in Python using the PyNN modelling language, 1404 1404 or in hxtorch, a PyTorch-based machine-learning-friendly API. The platform can ... ... @@ -1406,7 +1406,7 @@ 1406 1406 lang=en-DE style='font-family:"Times New Roman",serif'> </span><span 1407 1407 lang=en-DE>in addition, the NMPI web service provides batch-style access. The 1408 1408 modelling APIs employ common data formats for input and output data, e.g., 1409 -neo.</span></p> 1413 +neo."</span></p> 1410 1410 1411 1411 <h2></h2> 1412 1412 ... ... @@ -1423,6 +1423,8 @@ 1423 1423 connected clients. Already-made plugins include CircuitExplorer, DTI, 1424 1424 AtlasExplorer, CylindricCamera and MoleculeExplorer.</span></p> 1425 1425 1430 +<p class=MsoNormal><span lang=en-DE>https://github.com/BlueBrain/Brayns/ </span></p> 1431 + 1426 1426 <p class=MsoNormal></p> 1427 1427 1428 1428 <h2><a name="_Toc138932265"><span lang=en-DE>Brion</span></a></h2> ... ... @@ -1439,10 +1439,10 @@ 1439 1439 <p class=MsoNormal><span lang=en-DE>The BSB reconstructs realistic neural 1440 1440 circuits by placing and connecting fibres and neurons with detailed 1441 1441 morphologies or only simplified geometrical features. Configure your model the 1442 -way you need. Interfaces with several simulators (CoreNEURON, Arbor, NEST) 1448 +way you need. Interfaces with several simulators (?CoreNEURON, ?Arbor, ?NEST) 1443 1443 allow simulation of the reconstructed network and investigation of the 1444 1444 structure-function-dynamics relationships at different levels of resolution. 1445 -The 'scaffold'design allows an easy model reconfiguration reflecting variants1451 +The ÒscaffoldÓ design allows an easy model reconfiguration reflecting variants 1446 1446 across brain regions, animal species and physio-pathological conditions without 1447 1447 dismounting the basic network structure. The BSB provides effortless parallel 1448 1448 computing both for the reconstruction and simulation phase.</span></p> ... ... @@ -1452,8 +1452,8 @@ 1452 1452 <h2><a name="_Toc138932267"><span lang=en-DE>BSP Service Account</span></a></h2> 1453 1453 1454 1454 <p class=MsoNormal><span lang=en-DE>The BSP Service Account is a rest API 1455 -service that allows developers to submit user 's jobs on HPC systems and1456 -retrieve results using the EBRAINS authentication, even if users don 't have a1461 +service that allows developers to submit userÕs jobs on HPC systems and 1462 +retrieve results using the EBRAINS authentication, even if users donÕt have a 1457 1457 personal account on the available HPC facilities.</span></p> 1458 1458 1459 1459 <h2></h2> ... ... @@ -1523,11 +1523,11 @@ 1523 1523 EBRAINS infrastructure provider) and storage resources there. This is the 1524 1524 recommended storage for datasets that are shared by data providers, on the 1525 1525 condition that these do not contain sensitive personal data. For sharing 1526 -datasets with personal data, users should refer to the Health Data Cloud. The 1532 +datasets with personal data, users should refer to the ?Health Data Cloud. The 1527 1527 Bucket service is better suited for larger files that are usually not edited, 1528 1528 such as datasets and videos. For Docker images, users should refer to the 1529 1529 EBRAINS Docker registry. For smaller files and files which are more likely to 1530 -be edited, users should consider the Collaboratory Drive service.</span></p> 1536 +be edited, users should consider the ?Collaboratory Drive service.</span></p> 1531 1531 1532 1532 <h2></h2> 1533 1533 ... ... @@ -1535,12 +1535,12 @@ 1535 1535 1536 1536 <p class=MsoNormal><span lang=en-DE>The Drive service offers users cloud 1537 1537 storage space for their files in each collab (workspace). The Drive storage is 1538 -mounted in the Collaboratory Lab to provide persistent storage (as opposed to 1544 +mounted in the ?Collaboratory Lab to provide persistent storage (as opposed to 1539 1539 the Lab containers which are deleted after a few hours of inactivity). All 1540 1540 files are under version control. The Drive is intended for smaller files 1541 1541 (currently limited to 1 GB) that change more often. Users must not save files 1542 1542 containing personal information in the Drive (i.e. data of living human subjects). 1543 -The Drive is also integrated with the Collaboratory Office service to offer 1549 +The Drive is also integrated with the ?Collaboratory Office service to offer 1544 1544 easy collaborative editing of Office files online.</span></p> 1545 1545 1546 1546 <h2></h2> ... ... @@ -1655,7 +1655,7 @@ 1655 1655 interest by downloading a few tiles rather than the entire large image. Tiles 1656 1656 are also generated at coarser resolutions to support zooming out of large 1657 1657 images. The service supports multiple input image formats. The serving of tiles 1658 -to apps is provided by the Collaboratory Bucket (based on OpenStack Swift 1664 +to apps is provided by the ?Collaboratory Bucket (based on OpenStack Swift 1659 1659 object storage), which provides significantly higher network bandwidth than 1660 1660 could be provided by any VM.</span></p> 1661 1661 ... ... @@ -1724,12 +1724,12 @@ 1724 1724 <h2><a name="_Toc138932288"><span lang=en-DE>fairgraph</span></a></h2> 1725 1725 1726 1726 <p class=MsoNormal><span lang=en-DE>fairgraph is a Python library for working 1727 -with metadata in the EBRAINS Knowledge Graph (KG), with a particular focus on 1733 +with metadata in the ?EBRAINS Knowledge Graph (KG), with a particular focus on 1728 1728 data reuse, although it is also useful in registering and curating metadata. 1729 1729 The library represents metadata nodes (also known as openMINDS instances) from 1730 1730 the KG as Python objects. fairgraph supports querying the KG, following links 1731 1731 in the graph, downloading data and metadata, and creating new nodes in the KG. 1732 -It builds on openMINDS and on the KG Core Python library.</span></p> 1738 +It builds on ?openMINDS and on the KG Core Python library.</span></p> 1733 1733 1734 1734 <h2></h2> 1735 1735 ... ... @@ -1765,7 +1765,7 @@ 1765 1765 <p class=MsoNormal><span lang=en-DE>This tool was developed to calculate the 1766 1766 local field potentials (LFP) and magnetoencephalogram (MEG) signals generated 1767 1767 by a population of neurons described by a mean-field model. The calculation of 1768 -LFP is done via a kernel method based on unitary LFP 's (the LFP generated by a1774 +LFP is done via a kernel method based on unitary LFPÕs (the LFP generated by a 1769 1769 single axon) which was recently introduced for spiking-networks simulations and 1770 1770 that we adapt here for mean-field models. The calculation of the magnetic field 1771 1771 is based on current-dipole and volume-conductor models, where the secondary ... ... @@ -1853,7 +1853,7 @@ 1853 1853 (GDPR). The HDC is a federation of interoperable nodes. Nodes share a common 1854 1854 system architecture based on CharitŽ Virtual Research Environment (VRE), 1855 1855 enabling research consortia to manage and process data, and making data 1856 -discoverable and sharable via the EBRAINS Knowledge Graph.</span></p> 1862 +discoverable and sharable via the ?EBRAINS Knowledge Graph.</span></p> 1857 1857 1858 1858 <p class=MsoNormal></p> 1859 1859 ... ... @@ -1919,7 +1919,7 @@ 1919 1919 <h2><a name="_Toc138932304"><span lang=en-DE>Insite</span></a></h2> 1920 1920 1921 1921 <p class=MsoNormal><span lang=en-DE>Insite enables users to access data via the 1922 -in transit paradigm for NEST, TVB and Arbor simulations. Compared to the 1928 +in transit paradigm for ?NEST, ?TVB and ?Arbor simulations. Compared to the 1923 1923 traditional approach of offline processing, in transit paradigms allow 1924 1924 accessing of data while the simulation runs. This is especially useful for 1925 1925 simulations that produce large amounts of data and are running for a long time. ... ... @@ -1949,7 +1949,7 @@ 1949 1949 requires detailed insights into how areas with specific gene activities and 1950 1950 microanatomical architectures contribute to brain function and dysfunction. The 1951 1951 Allen Human Brain Atlas contains regional gene expression data, while the 1952 -Julich Brain Atlas, which can be accessed via siibra, offers 3D 1958 +Julich Brain Atlas, which can be accessed via ?siibra, offers 3D 1953 1953 cytoarchitectonic maps reflecting the interindividual variability. JuGEx offers 1954 1954 an integrated framework that combines the analytical benefits of both 1955 1955 repositories towards a multilevel brain atlas of adult humans. JuGEx is a new ... ... @@ -1967,7 +1967,7 @@ 1967 1967 large-scale brain initiatives universally accessible and useful. It also 1968 1968 promotes FAIR data principles that will help data publishers to follow best 1969 1969 practices for data storage and publication. As more and more data publishers 1970 -follow data standards like OpenMINDS or DATS, the quality of data discovery 1976 +follow data standards like ?OpenMINDS or DATS, the quality of data discovery 1971 1971 through KS will improve. The related publications are also curated from PubMed 1972 1972 and linked to the concepts in KS to provide an improved search capability.</span></p> 1973 1973 ... ... @@ -2072,7 +2072,7 @@ 2072 2072 Acceleration Molecular Dynamics (RAMD) trajectories, it can help to investigate 2073 2073 dissociation mechanisms by characterising transition states as well as the 2074 2074 determinants and hot-spots for dissociation. As such, the combined use of 2075 -RAMD and MD-IFP may assist the early stages of drug discovery campaigns for the 2081 +??RAMD and MD-IFP may assist the early stages of drug discovery campaigns for the 2076 2076 design of new molecules or ligand optimisation.</span></p> 2077 2077 2078 2078 <h2></h2> ... ... @@ -2227,14 +2227,14 @@ 2227 2227 2228 2228 <h2><a name="_Toc138932327"><span lang=en-DE>Multi-Brain</span></a></h2> 2229 2229 2230 -<p class=MsoNormal><span lang=en-DE>The Multi-Brain (MB) model has the 2236 +<p class=MsoNormal><span lang=en-DE>"The Multi-Brain (MB) model has the 2231 2231 general aim of integrating a number of disparate image analysis components 2232 2232 within a single unified generative modelling framework. Its objective is to 2233 2233 achieve diffeomorphic alignment of a wide variety of medical image modalities 2234 2234 into a common anatomical space. This involves the ability to construct a 2235 -"tissue probability template" from a population of scans 2241 +""tissue probability template"" from a population of scans 2236 2236 through group-wise alignment. The MB model has been shown to provide accurate 2237 -modelling of the intensity distributions of different imaging modalities.</span></p> 2243 +modelling of the intensity distributions of different imaging modalities."</span></p> 2238 2238 2239 2239 <h2></h2> 2240 2240 ... ... @@ -2272,7 +2272,7 @@ 2272 2272 of morphological neuron models. These models can be simulated through an 2273 2273 interface with the NEURON simulator or analysed with two classical methods: (i) 2274 2274 the separation-of-variables method to obtain impedance kernels as a 2275 -superposition of exponentials and (ii) Koch 's method to compute impedances with2281 +superposition of exponentials and (ii) KochÕs method to compute impedances with 2276 2276 linearised ion channels analytically in the frequency domain. NEAT also 2277 2277 implements the neural evaluation tree framework and an associated C++ simulator 2278 2278 to analyse sub-unit independence. Finally, NEAT implements a new method to ... ... @@ -2314,7 +2314,7 @@ 2314 2314 visualising and analysing simulation results. NEST Desktop allows students to 2315 2315 explore important concepts in computational neuroscience without the need to 2316 2316 first learn a simulator control language. This is done by offering a 2317 -server-side NEST simulator, which can also be installed as a package together 2323 +server-side ?NEST simulator, which can also be installed as a package together 2318 2318 with a web server providing NEST Desktop as visual front-end. Besides local 2319 2319 installations, distributed setups can be installed, and direct use through 2320 2320 EBRAINS is possible. NEST Desktop has also been used as a modelling front-end ... ... @@ -2340,7 +2340,7 @@ 2340 2340 2341 2341 <p class=MsoNormal><span lang=en-DE>NESTML is a domain-specific language for 2342 2342 neuron and synapse models. These dynamical models can be used in simulations of 2343 -brain activity on several platforms, in particular NEST Simulator. NESTML 2349 +brain activity on several platforms, in particular ?NEST Simulator. NESTML 2344 2344 combines an easy to understand, yet powerful syntax with good simulation 2345 2345 performance by means of code generation (C++ for NEST Simulator), but flexibly 2346 2346 supports other simulation engines including neuromorphic hardware.</span></p> ... ... @@ -2353,7 +2353,7 @@ 2353 2353 interfaces to develop data-driven multiscale brain neural circuit models using 2354 2354 Python and NEURON. Users can define models using a standardised 2355 2355 JSON-compatible, rule-based, declarative format. Based on these specifications, 2356 -NetPyNE will generate the network in CoreNEURON, enabling users to run 2362 +NetPyNE will generate the network in ?CoreNEURON, enabling users to run 2357 2357 parallel simulations, optimise and explore network parameters through automated 2358 2358 batch runs, and use built-in functions for visualisation and analysis (e.g., 2359 2359 generate connectivity matrices, voltage traces, spike raster plots, local field ... ... @@ -2441,8 +2441,8 @@ 2441 2441 2442 2442 <p class=MsoNormal><span lang=en-DE>NeuroR is a collection of tools to repair 2443 2443 morphologies. This includes cut plane detection, sanitisation (removing 2444 -unifurcations, invalid soma counts, short segments) and 'unravelling': the2445 -action of 'stretching'the cell that has been shrunk due to the dehydratation2450 +unifurcations, invalid soma counts, short segments) and ÒunravellingÓ: the 2451 +action of ÒstretchingÓ the cell that has been shrunk due to the dehydratation 2446 2446 caused by the slicing.</span></p> 2447 2447 2448 2448 <h2></h2> ... ... @@ -2479,7 +2479,7 @@ 2479 2479 2480 2480 <h2><a name="_Toc138932346"><span lang=en-DE>NeuroScheme</span></a></h2> 2481 2481 2482 -<p class=MsoNormal><span lang=en-DE>NeuroScheme uses schematic 2488 +<p class=MsoNormal><span lang=en-DE>"NeuroScheme uses schematic 2483 2483 representations, such as icons and glyphs, to encode attributes of neural 2484 2484 structures (neurons, columns, layers, populations, etc.), alleviating problems 2485 2485 with displaying, navigating and analysing large datasets. It manages ... ... @@ -2487,12 +2487,12 @@ 2487 2487 style='font-family:"Times New Roman",serif'> </span><span lang=en-DE>users can 2488 2488 navigate through the levels of the hierarchy and hone in on and explore the 2489 2489 data at their desired level of detail. NeuroScheme has currently two built-in 2490 -"domains", which specify entities, attributes and 2491 -relationships used for specific use cases: the 'cortex'domain, designed for2496 +""domains"", which specify entities, attributes and 2497 +relationships used for specific use cases: the ÒcortexÓ domain, designed for 2492 2492 navigating and analysing cerebral cortex structures</span><span lang=en-DE 2493 2493 style='font-family:"Times New Roman",serif'> </span><span lang=en-DE>and the 2494 - 'congen'domain, used to define the properties of cells and connections, create2495 -circuits of neurons and build populations.</span></p> 2500 +ÒcongenÓ domain, used to define the properties of cells and connections, create 2501 +circuits of neurons and build populations."</span></p> 2496 2496 2497 2497 <h2></h2> 2498 2498 ... ... @@ -2521,13 +2521,13 @@ 2521 2521 of neural circuits consisting of large numbers of cells. It facilitates the 2522 2522 recovery and visualisation of the 3D geometry of cells included in databases, 2523 2523 such as NeuroMorpho, and allows to approximate missing information such as the 2524 -soma 's morphology.</span></p>2530 +somaÕs morphology.</span></p> 2525 2525 2526 2526 <h2></h2> 2527 2527 2528 2528 <h2><a name="_Toc138932349"><span lang=en-DE>NMODL Framework</span></a></h2> 2529 2529 2530 -<p class=MsoNormal><span lang=en-DE>NMODL Framework is designed with 2536 +<p class=MsoNormal><span lang=en-DE>"NMODL Framework is designed with 2531 2531 modern compiler and code generation techniques. It provides modular tools for 2532 2532 parsing, analysing and transforming NMODL it provides an easy to use, high 2533 2533 level Python API</span><span lang=en-DE style='font-family:"Times New Roman",serif'> ... ... @@ -2534,7 +2534,7 @@ 2534 2534 </span><span lang=en-DE> it generates optimised code for modern compute architectures 2535 2535 including CPUs and GPUs</span><span lang=en-DE style='font-family:"Times New Roman",serif'> 2536 2536 </span><span lang=en-DE> it provides flexibility to implement new simulator 2537 -backends and it supports full NMODL specification.</span></p> 2543 +backends and it supports full NMODL specification."</span></p> 2538 2538 2539 2539 <h2></h2> 2540 2540 ... ... @@ -2643,7 +2643,7 @@ 2643 2643 2644 2644 <p class=MsoNormal><span lang=en-DE>The EBRAINS Provenance API is a web service 2645 2645 to facilitate working with computational provenance metadata. Metadata are 2646 -stored in the EBRAINS Knowledge Graph (KG) using openMINDS schemas. The 2652 +stored in the ?EBRAINS Knowledge Graph (KG) using openMINDS schemas. The 2647 2647 Provenance API provides a somewhat simplified interface compared to accessing 2648 2648 the KG directly and performs checks of metadata consistency. The service covers 2649 2649 workflows involving simulation, data analysis, visualisation, optimisation, ... ... @@ -2655,8 +2655,8 @@ 2655 2655 2656 2656 <p class=MsoNormal><span lang=en-DE>A model description written with the PyNN 2657 2657 API and the Python programming language runs on any simulator that PyNN 2658 -supports (currently NEURON, NEST and Brian 2) as well as on the BrainScaleS 2659 -and SpiNNaker neuromorphic hardware systems. PyNN provides a library of 2664 +supports (currently NEURON, ?NEST and Brian 2) as well as on the ?BrainScaleS 2665 +and ?SpiNNaker neuromorphic hardware systems. PyNN provides a library of 2660 2660 standard neuron, synapse and synaptic plasticity models, verified to work the 2661 2661 same on different simulators. PyNN also provides commonly used connectivity 2662 2662 algorithms (e.g. all-to-all, random, distance-dependent, small-world) but makes ... ... @@ -2723,10 +2723,10 @@ 2723 2723 <p class=MsoNormal><span lang=en-DE>RateML enables users to generate 2724 2724 whole-brain network models from a succinct declarative description, in which 2725 2725 the mathematics of the model are described without specifying how their 2726 -simulation should be implemented. RateML builds on NeuroML 's Low Entropy Model2732 +simulation should be implemented. RateML builds on NeuroMLÕs Low Entropy Model 2727 2727 Specification (LEMS), an XML-based language for specifying models of dynamical systems, 2728 2728 allowing descriptions of neural mass and discretized neural field models, as 2729 -implemented by the TVB simulator. The end user describes their model 's2735 +implemented by the TVB simulator. The end user describes their modelÕs 2730 2730 mathematics once and generates and runs code for different languages, targeting 2731 2731 both CPUs for fast single simulations and GPUs for parallel ensemble 2732 2732 simulations.</span></p> ... ... @@ -2737,7 +2737,7 @@ 2737 2737 BrainÊCytoarchitectonic Atlas</span></a></h2> 2738 2738 2739 2739 <p class=MsoNormal><span lang=en-DE>Many studies have been investigating the 2740 -relationships between interindividual variability in brain regions '2746 +relationships between interindividual variability in brain regionsÕ 2741 2741 connectivity and behavioural phenotypes, by utilising connectivity-based 2742 2742 prediction models. Recently, we demonstrated that an approach based on the 2743 2743 combination of whole-brain and region-wise CBPP can provide important insight ... ... @@ -2745,7 +2745,7 @@ 2745 2745 offering interpretable patterns. Here, we applied this approach using the 2746 2746 Julich Brain Cytoarchitectonic Atlas with the resting-state functional 2747 2747 connectivity and psychometric variables from the Human Connectome Project 2748 -dataset, illustrating each brain region 's predictive power for a range of2754 +dataset, illustrating each brain regionÕs predictive power for a range of 2749 2749 psychometric variables. As a result, a psychometric prediction profile was 2750 2750 established for each brain region, which can be validated against brain mapping 2751 2751 literature.</span></p> ... ... @@ -2830,7 +2830,7 @@ 2830 2830 <h2><a name="_Toc138932371"><span lang=en-DE>siibra-api</span></a></h2> 2831 2831 2832 2832 <p class=MsoNormal><span lang=en-DE>siibra-api provides an HTTP wrapper around 2833 -siibra-python, allowing developers to access atlas (meta)data over HTTP 2839 +?siibra-python, allowing developers to access atlas (meta)data over HTTP 2834 2834 protocol. Deployed on the EBRAINS infrastructure, developers can access the 2835 2835 centralised (meta)data on atlases, as provided by siibra-python, regardless of 2836 2836 the programming language.</span></p> ... ... @@ -2862,7 +2862,7 @@ 2862 2862 regional data features. It aims to facilitate programmatic and reproducible 2863 2863 incorporation of brain parcellations and brain region features from different 2864 2864 sources into neuroscience workflows. Also, siibra-python provides an easy 2865 -access to data features on the EBRAINS Knowledge Graph in a well-structured 2871 +access to data features on the ?EBRAINS Knowledge Graph in a well-structured 2866 2866 manner. Users can preconfigure their own data to use within siibra-python.</span></p> 2867 2867 2868 2868 <h2></h2> ... ... @@ -2895,7 +2895,7 @@ 2895 2895 2896 2896 <h2><a name="_Toc138932376"><span lang=en-DE>Snudda</span></a></h2> 2897 2897 2898 -<p class=MsoNormal><span lang=en-DE>Snudda ( 'touch'in Swedish) allows the user2904 +<p class=MsoNormal><span lang=en-DE>Snudda (ÔtouchÕ in Swedish) allows the user 2899 2899 to set up and generate microcircuits where the connectivity between neurons is 2900 2900 based on reconstructed neuron morphologies. The touch detection algorithm looks 2901 2901 for overlaps of axons and dendrites, and places putative synapses where they ... ... @@ -2957,7 +2957,7 @@ 2957 2957 data and prior assumptions on parameter distributions) are stored in a 2958 2958 structured, human- and machine-readable file format based on SBtab. The toolset 2959 2959 enables simulations of the same model in simulators with different 2960 -characteristics, e.g., STEPS, NEURON, MATLAB 's Simbiology and R via automatic2966 +characteristics, e.g., STEPS, NEURON, MATLABÕs Simbiology and R via automatic 2961 2961 code generation. The parameter estimation can include uncertainty 2962 2962 quantification and is done by optimisation or Bayesian approaches. Model 2963 2963 analysis includes global sensitivity analysis and functionality for analysing ... ... @@ -2969,7 +2969,7 @@ 2969 2969 2970 2970 <p class=MsoNormal><span lang=en-DE>The Synaptic Events Fitting is a web 2971 2971 application, implemented in a Jupyter Notebook on EBRAINS that allows users to 2972 -fit synaptic events using data and models from the EBRAINS Knowledge Graph 2978 +fit synaptic events using data and models from the ?EBRAINS Knowledge Graph 2973 2973 (KG). Select, download and visualise experimental data from the KG and then choose 2974 2974 the data to be fitted. A mod file is then selected (local or default) together 2975 2975 with the corresponding configuration file (including protocol and the name of ... ... @@ -2986,9 +2986,9 @@ 2986 2986 application, implemented via a Jupyter Notebook on EBRAINS, which allows to 2987 2987 configure and test, through an intuitive GUI, different synaptic plasticity 2988 2988 models and protocols on single cell optimised models, available in the EBRAINS 2989 -Model Catalog. It consists of two tabs: 'Config', where the user can specify2990 -the plasticity model to use and the synaptic parameters, and 'Sim', where the2991 -recording location, weight 's evolution and number of simulations to run are2995 +Model Catalog. It consists of two tabs: ÒConfigÓ, where the user can specify 2996 +the plasticity model to use and the synaptic parameters, and ÒSimÓ, where the 2997 +recording location, weightÕs evolution and number of simulations to run are 2992 2992 defined. The results are plotted at the end of the simulation and the traces 2993 2993 are available for download.</span></p> 2994 2994 ... ... @@ -3039,7 +3039,7 @@ 3039 3039 the simulation tools and adaptors connecting the data, atlas and computing 3040 3040 services to the rest of the TVB ecosystem and Cloud services available in 3041 3041 EBRAINS. As such it allows the user to find and fetch relevant datasets through 3042 -the EBRAINS Knowledge Graph and Atlas services, construct the personalised TVB 3048 +the ?EBRAINS Knowledge Graph and Atlas services, construct the personalised TVB 3043 3043 models and use the HPC systems to perform parameter exploration, optimisation and 3044 3044 inference studies. The user can orchestrate the workflow from the Jupyterlab 3045 3045 interactive computing environment of the EBRAINS Collaboratory or use the ... ... @@ -3065,7 +3065,7 @@ 3065 3065 3066 3066 <p class=MsoNormal><span lang=en-DE>The TVB Inversion package implements the 3067 3067 machinery required to perform parameter exploration and inference over 3068 -parameters of The Virtual Brain simulator. It implements Simulation Based 3074 +parameters of ?The Virtual Brain simulator. It implements Simulation Based 3069 3069 Inference (SBI) which is a Bayesian inference method for complex models, where 3070 3070 calculation of the likelihood function is either analytically or 3071 3071 computationally intractable. As such, it allows the user to formulate with ... ... @@ -3085,7 +3085,7 @@ 3085 3085 App uses private/public key cryptography, sandboxing, and access control to 3086 3086 protect personalised health information contained in digital human brain twins 3087 3087 while being processed on HPC. Users can upload their connectomes or use 3088 -TVB-ready image-derived data discoverable via the EBRAINS Knowledge Graph. 3094 +TVB-ready image-derived data discoverable via the ?EBRAINS Knowledge Graph. 3089 3089 Users can also use containerised processing workflows available on EBRAINS to 3090 3090 render image raw data into simulation-ready formats.</span></p> 3091 3091 ... ... @@ -3095,11 +3095,11 @@ 3095 3095 3096 3096 <p class=MsoNormal><span lang=en-DE>In order to support the usability of 3097 3097 EBRAINS workflows, TVB-widgets has been developed as a set of modular graphic 3098 -components and software solutions, easy to use in the Collaboratory within the 3104 +components and software solutions, easy to use in the ?Collaboratory within the 3099 3099 JupyterLab. These GUI components are based on and under open source licence, 3100 3100 supporting open neuroscience and support features like: Setup of models and 3101 3101 region-specific or cohort simulations. Selection of Data sources and their 3102 -links to models. Querying data from siibra and the EBRAINS Knowledge Graph. 3108 +links to models. Querying data from ?siibra and the ?EBRAINS Knowledge Graph. 3103 3103 Deployment and monitoring jobs on HPC resources. Analysis and visualisation. 3104 3104 Visual workflow builder for configuring and launching TVB simulations.</span></p> 3105 3105 ... ... @@ -3109,8 +3109,8 @@ 3109 3109 3110 3110 <p class=MsoNormal><span lang=en-DE>TVB-Multiscale is a Python toolbox aimed at 3111 3111 facilitating the configuration of multiscale brain models and their 3112 -co-simulation with TVB and spiking network simulators (currently NEST, 3113 -NetPyNE (NEURON) and ANNarchy). A multiscale brain model consists of a full 3118 +co-simulation with TVB and spiking network simulators (currently ?NEST, 3119 +?NetPyNE (NEURON) and ANNarchy). A multiscale brain model consists of a full 3114 3114 brain model formulated at the coarse scale of networks of tens up to thousands 3115 3115 of brain regions, and an additional model of networks of spiking neurons 3116 3116 describing selected brain regions at a finer scale. The toolbox has a ... ... @@ -3139,7 +3139,7 @@ 3139 3139 Explorer are the core of an application suite designed to help scientists to 3140 3140 explore their data. Vishnu 1.0 is a communication framework that allows them to 3141 3141 interchange information and cooperate in real time. It provides a unique access 3142 -point to the three applications and manages a database with the users '3148 +point to the three applications and manages a database with the usersÕ 3143 3143 datasets. Vishnu was originally designed to integrate data for 3144 3144 Espina.Whole-brain-scale tools.</span></p> 3145 3145 ... ... @@ -3162,7 +3162,7 @@ 3162 3162 <h2><a name="_Toc138932395"><span lang=en-DE>VisuAlign</span></a></h2> 3163 3163 3164 3164 <p class=MsoNormal><span lang=en-DE>VisuAlign is a tool for user-guided 3165 -nonlinear registration after QuickNII of 2D experimental image data, typically 3171 +nonlinear registration after ?QuickNII of 2D experimental image data, typically 3166 3166 high resolution microscopic images, to 3D atlas reference space, facilitating 3167 3167 data integration through standardised coordinate systems. Key features: 3168 3168 Generate user-defined cut planes through the atlas templates, matching the ... ... @@ -3202,8 +3202,8 @@ 3202 3202 3203 3203 <h2><a name="_Toc138932398"><span lang=en-DE>WebAlign</span></a></h2> 3204 3204 3205 -<p class=MsoNormal><span lang=en-DE>WebAlign is the web version of QuickNII. 3206 -Presently, it is available as a community app in the Collaboratory. Features 3211 +<p class=MsoNormal><span lang=en-DE>WebAlign is the web version of ?QuickNII. 3212 +Presently, it is available as a community app in the ?Collaboratory. Features 3207 3207 include: Spatial registration of sectional image data. Generation of customised 3208 3208 atlas maps for your sectional image data.</span></p> 3209 3209 ... ... @@ -3225,8 +3225,8 @@ 3225 3225 3226 3226 <h2><a name="_Toc138932400"><span lang=en-DE>WebWarp</span></a></h2> 3227 3227 3228 -<p class=MsoNormal><span lang=en-DE>WebWarp is the web version of VisuAlign. 3229 -Presently, it is available as a community app in the Collaboratory. Features 3234 +<p class=MsoNormal><span lang=en-DE>WebWarp is the web version of ?VisuAlign. 3235 +Presently, it is available as a community app in the ?Collaboratory. Features 3230 3230 include: Nonlinear refinements of atlas registration by WebAlign of sectional 3231 3231 image data. Generation of customised atlas maps for your sectional image data.</span></p> 3232 3232