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Summary

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... ... @@ -1,7 +1,11 @@
1 -**Human Brain Project Tools Description**
1 +EBRAINS offers an extensive range of data and also provides compute resources (High-performance computing and Neuromorphic hardware). SLU can guide your journey on EBRAINS, show you how you find tools/data/related research projects appropriate for your research, and help you translate your work from the structured formalization process of science to technical requirements on EBRAINS.
2 2  
3 -On this page you will find a list with a brief description of the tools we have for the HBP tools Book, if you have a suggestion or detect an omission please send your feedback to [[slu@ebrains.eu>>mailto:slu@ebrains.eu]].
3 +EBRAINS support teams will help you connect to the community and give you tips for creating your simulations and models. If you are a neuroscientist, professor, or student, or are you interested in brain-related research, simulation, AI, robotics, and brain-inspired hardware check out what EBRAINS has for you.
4 4  
5 +As a researcher, you might find yourself immersed in a continuous flow of information, data, environments, and platforms which offer different tools and aids to fulfill an investigation and publish your results. This new way to doing science helps us advance at a fast pace and reduces efforts on searching data and tests, also allows us to deploy state-of-the-art simulations that can improve the quality of our work, and increase the capacity of neuroscientists for multiscale neural activity modeling of the human brain network.
6 +
7 +On this page you will find a quick overview of the different tools and services available in EBRAINS. It will address, in an interactive way, how to use EBRAINS for specific use cases from the participants and focus on exploring all the potential that EBRAINS, as a digital research infrastructure, provides to its users. Researchers will have the opportunity to get creative and combine the different EBRAINS components to respond to existing questions and formulate new avenues based on collaboration, sharing, co-design, and innovation.
8 +
5 5  {{html}}
6 6  <html>
7 7  
... ... @@ -1309,7 +1309,7 @@
1309 1309  
1310 1310  <h2><a name="_Toc138932256"><span lang=en-DE>BioNAR</span></a></h2>
1311 1311  
1312 -<p class=MsoNormal><span lang=en-DE>BioNAR combines a selection of
1316 +<p class=MsoNormal><span lang=en-DE>&quot;BioNAR combines a selection of
1313 1313  existing R protocols for network analysis with newly designed original
1314 1314  methodological features to support step-by-step analysis of
1315 1315  biological/biomedical networks. BioNAR supports a pipeline approach where many
... ... @@ -1319,7 +1319,7 @@
1319 1319  independent annotation enrichment</span><span lang=en-DE style='font-family:
1320 1320  "Times New Roman",serif'> </span><span lang=en-DE>predict a proteins influence
1321 1321  within and across multiple sub-complexes in the network and estimate the
1322 -co-occurrence or linkage between meta-data at the network level.</span></p>
1326 +co-occurrence or linkage between meta-data at the network level.&quot;</span></p>
1323 1323  
1324 1324  <h2></h2>
1325 1325  
... ... @@ -1398,7 +1398,7 @@
1398 1398  
1399 1399  <h2><a name="_Toc138932263"><span lang=en-DE>BrainScaleS</span></a></h2>
1400 1400  
1401 -<p class=MsoNormal><span lang=en-DE>Emulate spiking neural networks in
1405 +<p class=MsoNormal><span lang=en-DE>&quot;Emulate spiking neural networks in
1402 1402  continuous time on the BrainScaleS analog neuromorphic computing system. Models
1403 1403  and experiments can be described in Python using the PyNN modelling language,
1404 1404  or in hxtorch, a PyTorch-based machine-learning-friendly API.  The platform can
... ... @@ -1406,7 +1406,7 @@
1406 1406  lang=en-DE style='font-family:"Times New Roman",serif'> </span><span
1407 1407  lang=en-DE>in addition, the NMPI web service provides batch-style access. The
1408 1408  modelling APIs employ common data formats for input and output data, e.g.,
1409 -neo.</span></p>
1413 +neo.&quot;</span></p>
1410 1410  
1411 1411  <h2></h2>
1412 1412  
... ... @@ -1423,6 +1423,8 @@
1423 1423  connected clients. Already-made plugins include CircuitExplorer, DTI,
1424 1424  AtlasExplorer, CylindricCamera and MoleculeExplorer.</span></p>
1425 1425  
1430 +<p class=MsoNormal><span lang=en-DE>https://github.com/BlueBrain/Brayns/ </span></p>
1431 +
1426 1426  <p class=MsoNormal></p>
1427 1427  
1428 1428  <h2><a name="_Toc138932265"><span lang=en-DE>Brion</span></a></h2>
... ... @@ -1439,10 +1439,10 @@
1439 1439  <p class=MsoNormal><span lang=en-DE>The BSB reconstructs realistic neural
1440 1440  circuits by placing and connecting fibres and neurons with detailed
1441 1441  morphologies or only simplified geometrical features. Configure your model the
1442 -way you need. Interfaces with several simulators (CoreNEURON, Arbor, NEST)
1448 +way you need. Interfaces with several simulators (?CoreNEURON, ?Arbor, ?NEST)
1443 1443  allow simulation of the reconstructed network and investigation of the
1444 1444  structure-function-dynamics relationships at different levels of resolution.
1445 -The 'scaffold' design allows an easy model reconfiguration reflecting variants
1451 +The ÒscaffoldÓ design allows an easy model reconfiguration reflecting variants
1446 1446  across brain regions, animal species and physio-pathological conditions without
1447 1447  dismounting the basic network structure. The BSB provides effortless parallel
1448 1448  computing both for the reconstruction and simulation phase.</span></p>
... ... @@ -1452,8 +1452,8 @@
1452 1452  <h2><a name="_Toc138932267"><span lang=en-DE>BSP Service Account</span></a></h2>
1453 1453  
1454 1454  <p class=MsoNormal><span lang=en-DE>The BSP Service Account is a rest API
1455 -service that allows developers to submit user's jobs on HPC systems and
1456 -retrieve results using the EBRAINS authentication, even if users don't have a
1461 +service that allows developers to submit userÕs jobs on HPC systems and
1462 +retrieve results using the EBRAINS authentication, even if users donÕt have a
1457 1457  personal account on the available HPC facilities.</span></p>
1458 1458  
1459 1459  <h2></h2>
... ... @@ -1523,11 +1523,11 @@
1523 1523  EBRAINS infrastructure provider) and storage resources there. This is the
1524 1524  recommended storage for datasets that are shared by data providers, on the
1525 1525  condition that these do not contain sensitive personal data. For sharing
1526 -datasets with personal data, users should refer to the Health Data Cloud. The
1532 +datasets with personal data, users should refer to the ?Health Data Cloud. The
1527 1527  Bucket service is better suited for larger files that are usually not edited,
1528 1528  such as datasets and videos. For Docker images, users should refer to the
1529 1529  EBRAINS Docker registry. For smaller files and files which are more likely to
1530 -be edited, users should consider the Collaboratory Drive service.</span></p>
1536 +be edited, users should consider the ?Collaboratory Drive service.</span></p>
1531 1531  
1532 1532  <h2></h2>
1533 1533  
... ... @@ -1535,12 +1535,12 @@
1535 1535  
1536 1536  <p class=MsoNormal><span lang=en-DE>The Drive service offers users cloud
1537 1537  storage space for their files in each collab (workspace). The Drive storage is
1538 -mounted in the Collaboratory Lab to provide persistent storage (as opposed to
1544 +mounted in the ?Collaboratory Lab to provide persistent storage (as opposed to
1539 1539  the Lab containers which are deleted after a few hours of inactivity). All
1540 1540  files are under version control. The Drive is intended for smaller files
1541 1541  (currently limited to 1 GB) that change more often. Users must not save files
1542 1542  containing personal information in the Drive (i.e. data of living human subjects).
1543 -The Drive is also integrated with the Collaboratory Office service to offer
1549 +The Drive is also integrated with the ?Collaboratory Office service to offer
1544 1544  easy collaborative editing of Office files online.</span></p>
1545 1545  
1546 1546  <h2></h2>
... ... @@ -1655,7 +1655,7 @@
1655 1655  interest by downloading a few tiles rather than the entire large image. Tiles
1656 1656  are also generated at coarser resolutions to support zooming out of large
1657 1657  images. The service supports multiple input image formats. The serving of tiles
1658 -to apps is provided by the Collaboratory Bucket (based on OpenStack Swift
1664 +to apps is provided by the ?Collaboratory Bucket (based on OpenStack Swift
1659 1659  object storage), which provides significantly higher network bandwidth than
1660 1660  could be provided by any VM.</span></p>
1661 1661  
... ... @@ -1724,12 +1724,12 @@
1724 1724  <h2><a name="_Toc138932288"><span lang=en-DE>fairgraph</span></a></h2>
1725 1725  
1726 1726  <p class=MsoNormal><span lang=en-DE>fairgraph is a Python library for working
1727 -with metadata in the EBRAINS Knowledge Graph (KG), with a particular focus on
1733 +with metadata in the ?EBRAINS Knowledge Graph (KG), with a particular focus on
1728 1728  data reuse, although it is also useful in registering and curating metadata.
1729 1729  The library represents metadata nodes (also known as openMINDS instances) from
1730 1730  the KG as Python objects. fairgraph supports querying the KG, following links
1731 1731  in the graph, downloading data and metadata, and creating new nodes in the KG.
1732 -It builds on openMINDS and on the KG Core Python library.</span></p>
1738 +It builds on ?openMINDS and on the KG Core Python library.</span></p>
1733 1733  
1734 1734  <h2></h2>
1735 1735  
... ... @@ -1765,7 +1765,7 @@
1765 1765  <p class=MsoNormal><span lang=en-DE>This tool was developed to calculate the
1766 1766  local field potentials (LFP) and magnetoencephalogram (MEG) signals generated
1767 1767  by a population of neurons described by a mean-field model. The calculation of
1768 -LFP is done via a kernel method based on unitary LFP's (the LFP generated by a
1774 +LFP is done via a kernel method based on unitary LFPÕs (the LFP generated by a
1769 1769  single axon) which was recently introduced for spiking-networks simulations and
1770 1770  that we adapt here for mean-field models. The calculation of the magnetic field
1771 1771  is based on current-dipole and volume-conductor models, where the secondary
... ... @@ -1853,7 +1853,7 @@
1853 1853  (GDPR). The HDC is a federation of interoperable nodes. Nodes share a common
1854 1854  system architecture based on CharitŽ Virtual Research Environment (VRE),
1855 1855  enabling research consortia to manage and process data, and making data
1856 -discoverable and sharable via the EBRAINS Knowledge Graph.</span></p>
1862 +discoverable and sharable via the ?EBRAINS Knowledge Graph.</span></p>
1857 1857  
1858 1858  <p class=MsoNormal></p>
1859 1859  
... ... @@ -1919,7 +1919,7 @@
1919 1919  <h2><a name="_Toc138932304"><span lang=en-DE>Insite</span></a></h2>
1920 1920  
1921 1921  <p class=MsoNormal><span lang=en-DE>Insite enables users to access data via the
1922 -in transit paradigm for NEST, TVB and Arbor simulations. Compared to the
1928 +in transit paradigm for ?NEST, ?TVB and ?Arbor simulations. Compared to the
1923 1923  traditional approach of offline processing, in transit paradigms allow
1924 1924  accessing of data while the simulation runs. This is especially useful for
1925 1925  simulations that produce large amounts of data and are running for a long time.
... ... @@ -1949,7 +1949,7 @@
1949 1949  requires detailed insights into how areas with specific gene activities and
1950 1950  microanatomical architectures contribute to brain function and dysfunction. The
1951 1951  Allen Human Brain Atlas contains regional gene expression data, while the
1952 -Julich Brain Atlas, which can be accessed via siibra, offers 3D
1958 +Julich Brain Atlas, which can be accessed via ?siibra, offers 3D
1953 1953  cytoarchitectonic maps reflecting the interindividual variability. JuGEx offers
1954 1954  an integrated framework that combines the analytical benefits of both
1955 1955  repositories towards a multilevel brain atlas of adult humans. JuGEx is a new
... ... @@ -1967,7 +1967,7 @@
1967 1967  large-scale brain initiatives universally accessible and useful. It also
1968 1968  promotes FAIR data principles that will help data publishers to follow best
1969 1969  practices for data storage and publication. As more and more data publishers
1970 -follow data standards like OpenMINDS or DATS, the quality of data discovery
1976 +follow data standards like ?OpenMINDS or DATS, the quality of data discovery
1971 1971  through KS will improve. The related publications are also curated from PubMed
1972 1972  and linked to the concepts in KS to provide an improved search capability.</span></p>
1973 1973  
... ... @@ -2072,7 +2072,7 @@
2072 2072  Acceleration Molecular Dynamics (RAMD) trajectories, it can help to investigate
2073 2073  dissociation mechanisms by characterising transition states as well as the
2074 2074  determinants and hot-spots for dissociation. As such, the combined use of
2075 -RAMD and MD-IFP may assist the early stages of drug discovery campaigns for the
2081 +??RAMD and MD-IFP may assist the early stages of drug discovery campaigns for the
2076 2076  design of new molecules or ligand optimisation.</span></p>
2077 2077  
2078 2078  <h2></h2>
... ... @@ -2227,14 +2227,14 @@
2227 2227  
2228 2228  <h2><a name="_Toc138932327"><span lang=en-DE>Multi-Brain</span></a></h2>
2229 2229  
2230 -<p class=MsoNormal><span lang=en-DE>The Multi-Brain (MB) model has the
2236 +<p class=MsoNormal><span lang=en-DE>&quot;The Multi-Brain (MB) model has the
2231 2231  general aim of integrating a number of disparate image analysis components
2232 2232  within a single unified generative modelling framework. Its objective is to
2233 2233  achieve diffeomorphic alignment of a wide variety of medical image modalities
2234 2234  into a common anatomical space. This involves the ability to construct a
2235 -&quot;tissue probability template&quot; from a population of scans
2241 +&quot;&quot;tissue probability template&quot;&quot; from a population of scans
2236 2236  through group-wise alignment. The MB model has been shown to provide accurate
2237 -modelling of the intensity distributions of different imaging modalities.</span></p>
2243 +modelling of the intensity distributions of different imaging modalities.&quot;</span></p>
2238 2238  
2239 2239  <h2></h2>
2240 2240  
... ... @@ -2272,7 +2272,7 @@
2272 2272  of morphological neuron models. These models can be simulated through an
2273 2273  interface with the NEURON simulator or analysed with two classical methods: (i)
2274 2274  the separation-of-variables method to obtain impedance kernels as a
2275 -superposition of exponentials and (ii) Koch's method to compute impedances with
2281 +superposition of exponentials and (ii) KochÕs method to compute impedances with
2276 2276  linearised ion channels analytically in the frequency domain. NEAT also
2277 2277  implements the neural evaluation tree framework and an associated C++ simulator
2278 2278  to analyse sub-unit independence. Finally, NEAT implements a new method to
... ... @@ -2314,7 +2314,7 @@
2314 2314  visualising and analysing simulation results. NEST Desktop allows students to
2315 2315  explore important concepts in computational neuroscience without the need to
2316 2316  first learn a simulator control language. This is done by offering a
2317 -server-side NEST simulator, which can also be installed as a package together
2323 +server-side ?NEST simulator, which can also be installed as a package together
2318 2318  with a web server providing NEST Desktop as visual front-end. Besides local
2319 2319  installations, distributed setups can be installed, and direct use through
2320 2320  EBRAINS is possible. NEST Desktop has also been used as a modelling front-end
... ... @@ -2340,7 +2340,7 @@
2340 2340  
2341 2341  <p class=MsoNormal><span lang=en-DE>NESTML is a domain-specific language for
2342 2342  neuron and synapse models. These dynamical models can be used in simulations of
2343 -brain activity on several platforms, in particular NEST Simulator. NESTML
2349 +brain activity on several platforms, in particular ?NEST Simulator. NESTML
2344 2344  combines an easy to understand, yet powerful syntax with good simulation
2345 2345  performance by means of code generation (C++ for NEST Simulator), but flexibly
2346 2346  supports other simulation engines including neuromorphic hardware.</span></p>
... ... @@ -2353,7 +2353,7 @@
2353 2353  interfaces to develop data-driven multiscale brain neural circuit models using
2354 2354  Python and NEURON. Users can define models using a standardised
2355 2355  JSON-compatible, rule-based, declarative format. Based on these specifications,
2356 -NetPyNE will generate the network in CoreNEURON, enabling users to run
2362 +NetPyNE will generate the network in ?CoreNEURON, enabling users to run
2357 2357  parallel simulations, optimise and explore network parameters through automated
2358 2358  batch runs, and use built-in functions for visualisation and analysis (e.g.,
2359 2359  generate connectivity matrices, voltage traces, spike raster plots, local field
... ... @@ -2441,8 +2441,8 @@
2441 2441  
2442 2442  <p class=MsoNormal><span lang=en-DE>NeuroR is a collection of tools to repair
2443 2443  morphologies.  This includes cut plane detection, sanitisation (removing
2444 -unifurcations, invalid soma counts, short segments) and 'unravelling': the
2445 -action of 'stretching' the cell that has been shrunk due to  the dehydratation
2450 +unifurcations, invalid soma counts, short segments) and ÒunravellingÓ: the
2451 +action of ÒstretchingÓ the cell that has been shrunk due to  the dehydratation
2446 2446  caused by the slicing.</span></p>
2447 2447  
2448 2448  <h2></h2>
... ... @@ -2479,7 +2479,7 @@
2479 2479  
2480 2480  <h2><a name="_Toc138932346"><span lang=en-DE>NeuroScheme</span></a></h2>
2481 2481  
2482 -<p class=MsoNormal><span lang=en-DE>NeuroScheme uses schematic
2488 +<p class=MsoNormal><span lang=en-DE>&quot;NeuroScheme uses schematic
2483 2483  representations, such as icons and glyphs, to encode attributes of neural
2484 2484  structures (neurons, columns, layers, populations, etc.), alleviating problems
2485 2485  with displaying, navigating and analysing large datasets. It manages
... ... @@ -2487,12 +2487,12 @@
2487 2487  style='font-family:"Times New Roman",serif'> </span><span lang=en-DE>users can
2488 2488  navigate through the levels of the hierarchy and hone in on and explore the
2489 2489  data at their desired level of detail. NeuroScheme has currently two built-in
2490 -&quot;domains&quot;, which specify entities, attributes and
2491 -relationships used for specific use cases: the 'cortex' domain, designed for
2496 +&quot;&quot;domains&quot;&quot;, which specify entities, attributes and
2497 +relationships used for specific use cases: the ÒcortexÓ domain, designed for
2492 2492  navigating and analysing cerebral cortex structures</span><span lang=en-DE
2493 2493  style='font-family:"Times New Roman",serif'> </span><span lang=en-DE>and the
2494 -'congen' domain, used to define the properties of cells and connections, create
2495 -circuits of neurons and build populations.</span></p>
2500 +ÒcongenÓ domain, used to define the properties of cells and connections, create
2501 +circuits of neurons and build populations.&quot;</span></p>
2496 2496  
2497 2497  <h2></h2>
2498 2498  
... ... @@ -2521,13 +2521,13 @@
2521 2521  of neural circuits consisting of large numbers of cells. It facilitates the
2522 2522  recovery and visualisation of the 3D geometry of cells included in databases,
2523 2523  such as NeuroMorpho, and allows to approximate missing information such as the
2524 -soma's morphology.</span></p>
2530 +somaÕs morphology.</span></p>
2525 2525  
2526 2526  <h2></h2>
2527 2527  
2528 2528  <h2><a name="_Toc138932349"><span lang=en-DE>NMODL Framework</span></a></h2>
2529 2529  
2530 -<p class=MsoNormal><span lang=en-DE>NMODL Framework is designed with
2536 +<p class=MsoNormal><span lang=en-DE>&quot;NMODL Framework is designed with
2531 2531  modern compiler and code generation techniques. It provides modular tools for
2532 2532  parsing, analysing and transforming NMODL it provides an easy to use, high
2533 2533  level Python API</span><span lang=en-DE style='font-family:"Times New Roman",serif'>
... ... @@ -2534,7 +2534,7 @@
2534 2534  </span><span lang=en-DE> it generates optimised code for modern compute architectures
2535 2535  including CPUs and GPUs</span><span lang=en-DE style='font-family:"Times New Roman",serif'>
2536 2536  </span><span lang=en-DE> it provides flexibility to implement new simulator
2537 -backends and it supports full NMODL specification.</span></p>
2543 +backends and it supports full NMODL specification.&quot;</span></p>
2538 2538  
2539 2539  <h2></h2>
2540 2540  
... ... @@ -2643,7 +2643,7 @@
2643 2643  
2644 2644  <p class=MsoNormal><span lang=en-DE>The EBRAINS Provenance API is a web service
2645 2645  to facilitate working with computational provenance metadata. Metadata are
2646 -stored in the EBRAINS Knowledge Graph (KG) using openMINDS schemas. The
2652 +stored in the ?EBRAINS Knowledge Graph (KG) using openMINDS schemas. The
2647 2647  Provenance API provides a somewhat simplified interface compared to accessing
2648 2648  the KG directly and performs checks of metadata consistency. The service covers
2649 2649  workflows involving simulation, data analysis, visualisation, optimisation,
... ... @@ -2655,8 +2655,8 @@
2655 2655  
2656 2656  <p class=MsoNormal><span lang=en-DE>A model description written with the PyNN
2657 2657  API and the Python programming language runs on any simulator that PyNN
2658 -supports (currently NEURON, NEST and Brian 2) as well as on the BrainScaleS
2659 -and SpiNNaker neuromorphic hardware systems. PyNN provides a library of
2664 +supports (currently NEURON, ?NEST and Brian 2) as well as on the ?BrainScaleS
2665 +and ?SpiNNaker neuromorphic hardware systems. PyNN provides a library of
2660 2660  standard neuron, synapse and synaptic plasticity models, verified to work the
2661 2661  same on different simulators. PyNN also provides commonly used connectivity
2662 2662  algorithms (e.g. all-to-all, random, distance-dependent, small-world) but makes
... ... @@ -2723,10 +2723,10 @@
2723 2723  <p class=MsoNormal><span lang=en-DE>RateML enables users to generate
2724 2724  whole-brain network models from a succinct declarative description, in which
2725 2725  the mathematics of the model are described without specifying how their
2726 -simulation should be implemented. RateML builds on NeuroML's Low Entropy Model
2732 +simulation should be implemented. RateML builds on NeuroMLÕs Low Entropy Model
2727 2727  Specification (LEMS), an XML-based language for specifying models of dynamical systems,
2728 2728  allowing descriptions of neural mass and discretized neural field models, as
2729 -implemented by the TVB simulator. The end user describes their model's
2735 +implemented by the TVB simulator. The end user describes their modelÕs
2730 2730  mathematics once and generates and runs code for different languages, targeting
2731 2731  both CPUs for fast single simulations and GPUs for parallel ensemble
2732 2732  simulations.</span></p>
... ... @@ -2737,7 +2737,7 @@
2737 2737  BrainÊCytoarchitectonic Atlas</span></a></h2>
2738 2738  
2739 2739  <p class=MsoNormal><span lang=en-DE>Many studies have been investigating the
2740 -relationships between interindividual variability in brain regions'
2746 +relationships between interindividual variability in brain regionsÕ
2741 2741  connectivity and behavioural phenotypes, by utilising connectivity-based
2742 2742  prediction models. Recently, we demonstrated that an approach based on the
2743 2743  combination of whole-brain and region-wise CBPP can provide important insight
... ... @@ -2745,7 +2745,7 @@
2745 2745  offering interpretable patterns. Here, we applied this approach using the
2746 2746  Julich Brain Cytoarchitectonic Atlas with the resting-state functional
2747 2747  connectivity and psychometric variables from the Human Connectome Project
2748 -dataset, illustrating each brain region's predictive power for a range of
2754 +dataset, illustrating each brain regionÕs predictive power for a range of
2749 2749  psychometric variables. As a result, a psychometric prediction profile was
2750 2750  established for each brain region, which can be validated against brain mapping
2751 2751  literature.</span></p>
... ... @@ -2830,7 +2830,7 @@
2830 2830  <h2><a name="_Toc138932371"><span lang=en-DE>siibra-api</span></a></h2>
2831 2831  
2832 2832  <p class=MsoNormal><span lang=en-DE>siibra-api provides an HTTP wrapper around
2833 -siibra-python, allowing developers to access atlas (meta)data over HTTP
2839 +?siibra-python, allowing developers to access atlas (meta)data over HTTP
2834 2834  protocol. Deployed on the EBRAINS infrastructure, developers can access the
2835 2835  centralised (meta)data on atlases, as provided by siibra-python, regardless of
2836 2836  the programming language.</span></p>
... ... @@ -2862,7 +2862,7 @@
2862 2862  regional data features. It aims to facilitate programmatic and reproducible
2863 2863  incorporation of brain parcellations and brain region features from different
2864 2864  sources into neuroscience workflows. Also, siibra-python provides an easy
2865 -access to data features on the EBRAINS Knowledge Graph in a well-structured
2871 +access to data features on the ?EBRAINS Knowledge Graph in a well-structured
2866 2866  manner. Users can preconfigure their own data to use within siibra-python.</span></p>
2867 2867  
2868 2868  <h2></h2>
... ... @@ -2895,7 +2895,7 @@
2895 2895  
2896 2896  <h2><a name="_Toc138932376"><span lang=en-DE>Snudda</span></a></h2>
2897 2897  
2898 -<p class=MsoNormal><span lang=en-DE>Snudda ('touch' in Swedish) allows the user
2904 +<p class=MsoNormal><span lang=en-DE>Snudda (ÔtouchÕ in Swedish) allows the user
2899 2899  to set up and generate microcircuits where the connectivity between neurons is
2900 2900  based on reconstructed neuron morphologies. The touch detection algorithm looks
2901 2901  for overlaps of axons and dendrites, and places putative synapses where they
... ... @@ -2957,7 +2957,7 @@
2957 2957  data and prior assumptions on parameter distributions) are stored in a
2958 2958  structured, human- and machine-readable file format based on SBtab. The toolset
2959 2959  enables simulations of the same model in simulators with different
2960 -characteristics, e.g., STEPS, NEURON, MATLAB's Simbiology and R via automatic
2966 +characteristics, e.g., STEPS, NEURON, MATLABÕs Simbiology and R via automatic
2961 2961  code generation. The parameter estimation can include uncertainty
2962 2962  quantification and is done by optimisation or Bayesian approaches. Model
2963 2963  analysis includes global sensitivity analysis and functionality for analysing
... ... @@ -2969,7 +2969,7 @@
2969 2969  
2970 2970  <p class=MsoNormal><span lang=en-DE>The Synaptic Events Fitting is a web
2971 2971  application, implemented in a Jupyter Notebook on EBRAINS that allows users to
2972 -fit synaptic events using data and models from the EBRAINS Knowledge Graph
2978 +fit synaptic events using data and models from the ?EBRAINS Knowledge Graph
2973 2973  (KG). Select, download and visualise experimental data from the KG and then choose
2974 2974  the data to be fitted. A mod file is then selected (local or default) together
2975 2975  with the corresponding configuration file (including protocol and the name of
... ... @@ -2986,9 +2986,9 @@
2986 2986  application, implemented via a Jupyter Notebook on EBRAINS, which allows to
2987 2987  configure and test, through an intuitive GUI, different synaptic plasticity
2988 2988  models and protocols on single cell optimised models, available in the EBRAINS
2989 -Model Catalog. It consists of two tabs: 'Config', where the user can specify
2990 -the plasticity model to use and the synaptic parameters, and 'Sim', where the
2991 -recording location, weight's evolution and number of simulations to run are
2995 +Model Catalog. It consists of two tabs: ÒConfigÓ, where the user can specify
2996 +the plasticity model to use and the synaptic parameters, and ÒSimÓ, where the
2997 +recording location, weightÕs evolution and number of simulations to run are
2992 2992  defined. The results are plotted at the end of the simulation and the traces
2993 2993  are available for download.</span></p>
2994 2994  
... ... @@ -3039,7 +3039,7 @@
3039 3039  the simulation tools and adaptors connecting the data, atlas and computing
3040 3040  services to the rest of the TVB ecosystem and Cloud services available in
3041 3041  EBRAINS. As such it allows the user to find and fetch relevant datasets through
3042 -the EBRAINS Knowledge Graph and Atlas services, construct the personalised TVB
3048 +the ?EBRAINS Knowledge Graph and Atlas services, construct the personalised TVB
3043 3043  models and use the HPC systems to perform parameter exploration, optimisation and
3044 3044  inference studies. The user can orchestrate the workflow from the Jupyterlab
3045 3045  interactive computing environment of the EBRAINS Collaboratory or use the
... ... @@ -3065,7 +3065,7 @@
3065 3065  
3066 3066  <p class=MsoNormal><span lang=en-DE>The TVB Inversion package implements the
3067 3067  machinery required to perform parameter exploration and  inference over
3068 -parameters of The Virtual Brain simulator. It implements Simulation Based
3074 +parameters of ?The Virtual Brain simulator. It implements Simulation Based
3069 3069  Inference (SBI) which is a Bayesian inference method for complex models, where
3070 3070  calculation of the likelihood function is either analytically or
3071 3071  computationally intractable. As such, it allows the user to formulate with
... ... @@ -3085,7 +3085,7 @@
3085 3085  App uses private/public key cryptography, sandboxing, and access control to
3086 3086  protect personalised health information contained in digital human brain twins
3087 3087  while being processed on HPC. Users can upload their connectomes or use
3088 -TVB-ready image-derived data discoverable via the EBRAINS Knowledge Graph.
3094 +TVB-ready image-derived data discoverable via the ?EBRAINS Knowledge Graph.
3089 3089  Users can also use containerised processing workflows available on EBRAINS to
3090 3090  render image raw data into simulation-ready formats.</span></p>
3091 3091  
... ... @@ -3095,11 +3095,11 @@
3095 3095  
3096 3096  <p class=MsoNormal><span lang=en-DE>In order to support the usability of
3097 3097  EBRAINS workflows, TVB-widgets has been developed as a set of modular graphic
3098 -components and software solutions, easy to use in the Collaboratory within the
3104 +components and software solutions, easy to use in the ?Collaboratory within the
3099 3099  JupyterLab. These GUI components are based on and under open source licence,
3100 3100  supporting open neuroscience and support features like: Setup of models and
3101 3101  region-specific or cohort simulations. Selection of Data sources and their
3102 -links to models. Querying data from siibra and the EBRAINS Knowledge Graph.
3108 +links to models. Querying data from ?siibra and the ?EBRAINS Knowledge Graph.
3103 3103  Deployment and monitoring jobs on HPC resources. Analysis and visualisation.
3104 3104  Visual workflow builder for configuring and launching TVB simulations.</span></p>
3105 3105  
... ... @@ -3109,8 +3109,8 @@
3109 3109  
3110 3110  <p class=MsoNormal><span lang=en-DE>TVB-Multiscale is a Python toolbox aimed at
3111 3111  facilitating the configuration of multiscale brain models and their
3112 -co-simulation with TVB and spiking network simulators (currently NEST,
3113 -NetPyNE (NEURON) and ANNarchy). A multiscale brain model consists of a full
3118 +co-simulation with TVB and spiking network simulators (currently ?NEST,
3119 +?NetPyNE (NEURON) and ANNarchy). A multiscale brain model consists of a full
3114 3114  brain model formulated at the coarse scale of networks of tens up to thousands
3115 3115  of brain regions, and an additional model of networks of spiking neurons
3116 3116  describing selected brain regions at a finer scale. The toolbox has a
... ... @@ -3139,7 +3139,7 @@
3139 3139  Explorer are the core of an application suite designed to help scientists to
3140 3140  explore their data. Vishnu 1.0 is a communication framework that allows them to
3141 3141  interchange information and cooperate in real time. It provides a unique access
3142 -point to the three applications and manages a database with the users'
3148 +point to the three applications and manages a database with the usersÕ
3143 3143  datasets. Vishnu was originally designed to integrate data for
3144 3144  Espina.Whole-brain-scale tools.</span></p>
3145 3145  
... ... @@ -3162,7 +3162,7 @@
3162 3162  <h2><a name="_Toc138932395"><span lang=en-DE>VisuAlign</span></a></h2>
3163 3163  
3164 3164  <p class=MsoNormal><span lang=en-DE>VisuAlign is a tool for user-guided
3165 -nonlinear registration after QuickNII of 2D experimental image data, typically
3171 +nonlinear registration after ?QuickNII of 2D experimental image data, typically
3166 3166  high resolution microscopic images, to 3D atlas reference space, facilitating
3167 3167  data integration through standardised coordinate systems. Key features:
3168 3168  Generate user-defined cut planes through the atlas templates, matching the
... ... @@ -3202,8 +3202,8 @@
3202 3202  
3203 3203  <h2><a name="_Toc138932398"><span lang=en-DE>WebAlign</span></a></h2>
3204 3204  
3205 -<p class=MsoNormal><span lang=en-DE>WebAlign is the web version of QuickNII.
3206 -Presently, it is available as a community app in the Collaboratory. Features
3211 +<p class=MsoNormal><span lang=en-DE>WebAlign is the web version of ?QuickNII.
3212 +Presently, it is available as a community app in the ?Collaboratory. Features
3207 3207  include: Spatial registration of sectional image data. Generation of customised
3208 3208  atlas maps for your sectional image data.</span></p>
3209 3209  
... ... @@ -3225,8 +3225,8 @@
3225 3225  
3226 3226  <h2><a name="_Toc138932400"><span lang=en-DE>WebWarp</span></a></h2>
3227 3227  
3228 -<p class=MsoNormal><span lang=en-DE>WebWarp is the web version of VisuAlign.
3229 -Presently, it is available as a community app in the Collaboratory. Features
3234 +<p class=MsoNormal><span lang=en-DE>WebWarp is the web version of ?VisuAlign.
3235 +Presently, it is available as a community app in the ?Collaboratory. Features
3230 3230  include: Nonlinear refinements of atlas registration by WebAlign of sectional
3231 3231  image data. Generation of customised atlas maps for your sectional image data.</span></p>
3232 3232  
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SLU_HBPB