Changes for page Subcellular Modeling and Simulation services
Last modified by oliviaeriksson on 2022/12/13 14:50
From version 16.1
edited by oliviaeriksson
on 2022/12/13 14:33
on 2022/12/13 14:33
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To version 17.1
edited by oliviaeriksson
on 2022/12/13 14:45
on 2022/12/13 14:45
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... ... @@ -20,7 +20,7 @@ 20 20 21 21 [[image:image-20221213143123-1.png]] 22 22 23 -**The Subcellular Model building and Calibration toolset. ** //Model and data box~://The model together with the experimental data used for calibration are contained withinthe SBtabformat.Herearealsoinformationonmodelparameters,likeprior knowledge/assumptionsonpossibleranges forparameters beforeparameter estimation/calibrationtakesplace.//Calibration or Analysis box~://thetoolset includesdifferentmethods for calibration(estimation) ofparameters as wellas methodsfor model analysis, like differentkindsof sensitivity analysis methods. Theinformation retrieved within thisbox are fed backto the SBtabfilesofthe //Model and data box//.//Communication and Other simulations boxes://For interoperability, thetoolset alsoconsists of functionalities for transferringthe SBtab filesto othermodelformats likeSBML. Bythis the model canfor examplebe run in theSubcellularSimulationWebapp (see below). Itis also possibleto perform//model reductionbeforethe calibration takes place.23 +(% class="small" %)**The Subcellular Model building and Calibration tool set. **The model together with the experimental data and other information used for calibration are contained within a unified format based on SBtab [1] (//Model and data box//). This is the input to the calibration (parameter estimation) and analysis tools (//Calibration or Analysis box). //The model can also be transferred to different other// formats //like SBML or MOD// (Communication and Other simulations boxes). //Before calibration is performed the model can be reduced in size// (model reduction).// 24 24 25 25 [1] Lubitz, T., Hahn, J., Bergmann, F.T., Noor, E.,. Klipp, E, Liebermeister, W. (2016). SBtab: A flexible table format for data exchange in systems biology. Bioinformatics, 15;32(16), 2559-61. 26 26