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21	21	[[image:image-20221213143123-1.png]]
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23		-(% class="small" %)**The Subcellular Model building and Calibration tool set. **The model together with the experimental data and other information used for calibration are contained within a unified format based on SBtab [1] (//Model and data box//).  This is the input to the calibration (parameter estimation) and analysis tools (//Calibration or Analysis box). //The model can also be transferred to different other// formats //like SBML or MOD// (Communication and Other simulations boxes). //Before calibration is performed the model can be reduced in size// (model reduction).//
	23	+**The Subcellular Model building and Calibration toolset. **//Model and data box~:// The model together with the experimental data used for calibration are contained within the SBtab format. Here are also information on model parameters, like prior knowledge/assumptions on possible ranges for parameters before parameter estimation/calibration takes place. //Calibration or Analysis box~:// the toolset includes different methods for calibration (estimation) of parameters as well as methods for model analysis, like different kinds of sensitivity analysis methods. The information retrieved within this box are fed back to the SBtab files of the //Model and data box//. //Communication and Other simulations boxes: //For interoperability, the toolset also consists of functionalities for transferring the SBtab files to other model formats like SBML. By this the model can for example be run in the Subcellular Simulation Webapp (see below). It is also possible to perform //model reduction //before the calibration takes place.
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25	25	[1] Lubitz, T., Hahn, J., Bergmann, F.T., Noor, E.,. Klipp, E, Liebermeister, W. (2016). SBtab: A flexible table format for data exchange in systems biology. Bioinformatics, 15;32(16), 2559-61.
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