Changes for page Mesocircuit

Last modified by senk on 2022/05/23 22:36
From version 2.1
edited by terhorst
on 2020/04/29 14:00
Change comment: There is no comment for this version
To version 10.1
edited by senk
on 2020/05/03 21:24
Change comment: There is no comment for this version

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1 +XWiki.senk
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2 2  (((
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5 -= My Collab's Extended Title =
5 += **The cortical mesocircuit model** =
6 6  
7 -My collab's subtitle
7 +A layered network model covering 4x4 mm² of cortical surface area
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17 += Overview =
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19 +The cortical mesocircuit model is a lateral extension of the microcircuit model published by [[Potjans & Diesmann (2014)>>https://doi.org/10.1093/cercor/bhs358]].
22 22  
23 -Describe the audience of this collab.
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22 +[[image:mesocircuit_sketch.png||height="333" width="500"]]
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29 29  {{box title="**Contents**"}}
30 30  {{toc/}}
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34 +Like the microcircuit, the mesocircuit represents four layers of cortex, L2/3, L4, L5, and L6, each consisting of a population of excitatory neurons and a population of inhibitory neurons. External input can be provided by a thalamic population TC.
35 +
36 +The mesocircuit is a spatially structured network model covering 4x4 mm² of cortical surface area which is similar in size to multi-electrode arrays in use today.
37 +
38 +The neurons of each population are assigned random positions in 2-dimensional layers and they are connected with distance-dependent connection probabilities and conduction delays.
39 +
40 +The densities of neurons and local synapses in the network are assumed to be realistic, amounting to ~~1.2 million neurons and ~~5.5 billion synapses.
41 +
42 +The model accounts for both spiking activity simulated with [[NEST>>https://www.nest-simulator.org]] and local-field potentials relying on [[LFPy>>https://LFPy.rtfd.io]].
43 +
44 +(% class="row" id="HStatusofmodeldevelopment" %)
45 += Status of model development =
46 +
47 +The mesocircuit is still under development and the neither the code nor a peer-reviewed manuscript have been published, yet.
48 +
49 +To date, only a [[preprint>>https://arxiv.org/abs/1805.10235]] with detailed model documentation and preliminary results is available on ArXiv.
50 +
51 +The Drive of this Collab provides access to a [[recent version of the model implementation>>https://wiki.ebrains.eu/bin/view/Collabs/mesocircuit/Drive]].
52 +
53 +The development of the mesocircuit model belongs to task "SGA2 T4.2.1 - Spiking mesoscale cortical models with spatial organization" and constitutes the [[component C2418>>https://plus.humanbrainproject.eu/components/2418]].
54 +
55 +The main contributors are Johanna Senk, Espen Hagen, Sacha van Albada and Markus Diesmann.
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mesocircuit_sketch.png
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Mesocircuit