Wiki source code of Mesocircuit

Last modified by senk on 2022/05/23 22:36
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5 = **The cortical mesocircuit model** =
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7 A layered network model covering 4x4 mm² of cortical surface area
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17 = Overview =
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19 The cortical mesocircuit model is a lateral extension of the microcircuit model published by [[Potjans & Diesmann (2014)>>https://doi.org/10.1093/cercor/bhs358]].
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22 [[image:mesocircuit_sketch.png||height="333" width="500"]]
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27 {{box title="**Contents**"}}
28 {{toc/}}
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34 Like the microcircuit, the mesocircuit represents four layers of cortex, L2/3, L4, L5, and L6, each consisting of a population of excitatory neurons and a population of inhibitory neurons. External input can be provided by a thalamic population TC.
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36 The mesocircuit is a spatially structured network model covering 4x4 mm² of cortical surface area which is similar in size to multi-electrode arrays in use today.
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38 The neurons of each population are assigned random positions in two-dimensional layers and they are connected with distance-dependent connection probabilities and conduction delays.
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40 The densities of neurons and local synapses in the network are assumed to be realistic, amounting to ~~1.2 million neurons and ~~5.5 billion synapses.
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42 The model accounts for both spiking activity simulated with [[NEST>>https://www.nest-simulator.org]] and local-field potentials relying on [[LFPy>>https://LFPy.rtfd.io]].
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45 = Status of model development =
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47 The mesocircuit is still under development and the neither the code nor a peer-reviewed manuscript have been published, yet.
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49 To date, only a [[preprint>>https://arxiv.org/abs/1805.10235]] with detailed model documentation and preliminary results is available on arXiv.org.
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51 The Drive of this Collab provides access to a [[recent version of the model implementation>>https://wiki.ebrains.eu/bin/view/Collabs/mesocircuit/Drive]].
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53 The development of the mesocircuit model belongs to task "SGA2 T4.2.1 - Spiking mesoscale cortical models with spatial organization" and constitutes the [[component C2418>>https://plus.humanbrainproject.eu/components/2418]].
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55 The main contributors are Johanna Senk, Espen Hagen, Sacha J. van Albada and Markus Diesmann.
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Mesocircuit