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5		-= A mesoscopic layered cortical network model =
	5	+= **The cortical mesocircuit model** =
	6	+
	7	+A layered network model covering 4x4 mm² of cortical surface area
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13		-= [[image:mesocircuit_sketch.png]] =
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15		-= What can I find here? =
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	17	+= Overview =
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17		-* Notice how the table of contents on the right
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	19	+The cortical mesocircuit model is a lateral extension of the microcircuit model published by [[Potjans & Diesmann (2014)>>https://doi.org/10.1093/cercor/bhs358]].
20	20
21		-= Who has access? =
22		-
23		-Describe the audience of this collab.
	21	+[[image:mesocircuit_sketch.png||height="277" width="340"]]
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29	29	{{box title="**Contents**"}}
30	30	{{toc/}}
31	31	{{/box}}
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	33	+Like the microcircuit, the mesocircuit represents four layers of cortex, L2/3, L4, L5, and L6, each consisting of a population of excitatory neurons and a population of inhibitory neurons. External input can be provided by a thalamic population TC.
	34	+
	35	+The mesocircuit is a spatially structured network model covering 4x4 mm² of cortical surface area which is similar in size to multi-electrode arrays in use today.
	36	+
	37	+The neurons of each population are assigned random positions in 2-dimensional layers and they are connected with distance-dependent connection probabilities and conduction delays.
	38	+
	39	+The densities of neurons and local synapses in the network are assumed to be realistic, amounting to ~~1.2 million neurons and ~~5.5 billion synapses.
	40	+
	41	+The model accounts for both spiking activity simulated with [[NEST>>https://www.nest-simulator.org]] and local-field potentials relying on [[LFPy>>https://LFPy.rtfd.io]].
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	44	+= Status of model development =
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	46	+The mesocircuit is still under development and the neither the code nor a peer-reviewed manuscript have been published, yet.
	47	+
	48	+To date, only a [[preprint>>https://arxiv.org/abs/1805.10235]] with detailed model documentation and preliminary results is available on ArXiv.
	49	+
	50	+The Drive of this Collab provides access to a [[recent version of the model implementation>>https://wiki.ebrains.eu/bin/view/Collabs/mesocircuit/Drive]].
	51	+
	52	+The development of the mesocircuit model belongs to task "T4.2.1 - Spiking mesoscale cortical models with spatial organization" and constitutes the [[component C2418>>https://plus.humanbrainproject.eu/components/2418]].
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