Wiki source code of Mesocircuit
Show last authors
| author | version | line-number | content |
|---|---|---|---|
| 1 | (% class="jumbotron" %) | ||
| 2 | ((( | ||
| 3 | (% class="container" %) | ||
| 4 | ((( | ||
| 5 | = **The cortical mesocircuit model** = | ||
| 6 | |||
| 7 | A layered network model covering 4x4 mm² of cortical surface area | ||
| 8 | ))) | ||
| 9 | ))) | ||
| 10 | |||
| 11 | (% class="col-xs-12 col-sm-8" %) | ||
| 12 | ((( | ||
| 13 | (% class="row" %) | ||
| 14 | |||
| 15 | |||
| 16 | (% class="row" id="HOverview" %) | ||
| 17 | = Overview = | ||
| 18 | |||
| 19 | The cortical mesocircuit model is a lateral extension of the microcircuit model published by [[Potjans & Diesmann (2014)>>https://doi.org/10.1093/cercor/bhs358]]. | ||
| 20 | |||
| 21 | (% style="text-align:center" %) | ||
| 22 | [[image:mesocircuit_sketch.png||height="333" width="500"]] | ||
| 23 | ))) | ||
| 24 | |||
| 25 | (% class="col-xs-12 col-sm-4" %) | ||
| 26 | ((( | ||
| 27 | {{box title="**Contents**"}} | ||
| 28 | {{toc/}} | ||
| 29 | {{/box}} | ||
| 30 | ))) | ||
| 31 | |||
| 32 | (% class="col-xs-12 col-sm-12" %) | ||
| 33 | ((( | ||
| 34 | Like the microcircuit, the mesocircuit represents four layers of cortex, L2/3, L4, L5, and L6, each consisting of a population of excitatory neurons and a population of inhibitory neurons. External input can be provided by a thalamic population TC. | ||
| 35 | |||
| 36 | The mesocircuit is a spatially structured network model covering 4x4 mm² of cortical surface area which is similar in size to multi-electrode arrays in use today. | ||
| 37 | |||
| 38 | The neurons of each population are assigned random positions in two-dimensional layers and they are connected with distance-dependent connection probabilities and conduction delays. | ||
| 39 | |||
| 40 | The densities of neurons and local synapses in the network are assumed to be realistic, amounting to ~~1.2 million neurons and ~~5.5 billion synapses. | ||
| 41 | |||
| 42 | The model accounts for both spiking activity simulated with [[NEST>>https://www.nest-simulator.org]] and local-field potentials relying on [[LFPy>>https://LFPy.rtfd.io]]. | ||
| 43 | |||
| 44 | (% class="row" id="HStatusofmodeldevelopment" %) | ||
| 45 | = Status of model development = | ||
| 46 | |||
| 47 | The mesocircuit is still under development and the neither the code nor a peer-reviewed manuscript have been published, yet. | ||
| 48 | |||
| 49 | To date, only a [[preprint>>https://arxiv.org/abs/1805.10235]] with detailed model documentation and preliminary results is available on ArXiv. | ||
| 50 | |||
| 51 | The Drive of this Collab provides access to a [[recent version of the model implementation>>https://wiki.ebrains.eu/bin/view/Collabs/mesocircuit/Drive]]. | ||
| 52 | |||
| 53 | The development of the mesocircuit model belongs to task "SGA2 T4.2.1 - Spiking mesoscale cortical models with spatial organization" and constitutes the [[component C2418>>https://plus.humanbrainproject.eu/components/2418]]. | ||
| 54 | |||
| 55 | The main contributors are Johanna Senk, Espen Hagen, Sacha van Albada and Markus Diesmann. | ||
| 56 | ))) |